Optimal AraC-Cytotoxicity to AML Cells Requires ERK5 Activity

Keep Harm at Bay: Oxidative Phosphorylation Induces Nrf2-Driven Antioxidant Response Via ERK5/MEF2/miR-23a Signaling to Keap-1

(2016) Michael Danilenko et al.   EBioMedicine

Human Leukemic Cells performing Oxidative Phosphorylation (OXPHOS) Generate an Antioxidant Response Independently of Reactive Oxygen species (ROS) Production

(2016) Abrar Ul Haq Khan et al.   EBioMedicine

The MAPK ERK5, but not ERK1/2, inhibits the progression of monocytic phenotype to the functioning macrophage

(2015) Xuening Wang et al.   EXPERIMENTAL CELL RESEARCH

1,25-Dihydroxyvitamin D3 induces monocytic differentiation of human myeloid leukemia cells by regulating C/EBPβ expression through MEF2C

(2015) Ruifang Zheng et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Contribution of Bcl-2 Phosphorylation to Bak Binding and Drug Resistance

(2013) H. Dai et al.   CANCER RESEARCH

ERK5 Pathway Regulates Transcription Factors Important for Monocytic Differentiation of Human Myeloid Leukemia Cells

(2013) Xuening Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

ERK 5/MAPK pathway has a major role in 1α,25-(OH)2 vitamin D3-induced terminal differentiation of myeloid leukemia cells

(2013) Xuening Wang et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Canonical and Kinase Activity-Independent Mechanisms for Extracellular Signal-Regulated Kinase 5 (ERK5) Nuclear Translocation Require Dissociation of Hsp90 from the ERK5-Cdc37 Complex

(2013) T. Erazo et al.   MOLECULAR AND CELLULAR BIOLOGY

The extracellular-regulated protein kinase 5 (ERK5) promotes cell proliferation through the down-regulation of inhibitors of cyclin dependent protein kinases (CDKs)

(2012) Diana Perez-Madrigal et al.   CELLULAR SIGNALLING

Targeted Deletion of ERK5 MAP Kinase in the Developing Nervous System Impairs Development of GABAergic Interneurons in the Main Olfactory Bulb and Behavioral Discrimination between Structurally Similar Odorants

(2012) J. Zou et al.   JOURNAL OF NEUROSCIENCE

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

(2011) M. Cargnello et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and upregulates p27Kip1concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D3

(2010) Xuening Wang et al.   CELL CYCLE

Current and emerging therapies for acute myeloid leukemia

(2010) Tadeusz Robak et al.   CLINICAL THERAPEUTICS

MEK5/ERK5 Signaling Modulates Endothelial Cell Migration and Focal Contact Turnover

(2009) Désirée Spiering et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic factors influencing cytarabine therapy

(2009) Jatinder K Lamba   PHARMACOGENOMICS

Identification of pharmacological inhibitors of the MEK5/ERK5 pathway

(2008) Revati J. Tatake et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A novel role of ERK5 in integrin-mediated cell adhesion and motility in cancer cells via Fak signaling

(2008) Rajinder S. Sawhney et al.   JOURNAL OF CELLULAR PHYSIOLOGY