Interkinetic nuclear migration and basal tethering facilitates post-mitotic daughter separation in intestinal organoids

Adenomatous polyposis coli nucleates actin assembly to drive cell migration and microtubule-induced focal adhesion turnover

(2017) M. Angeles Juanes et al.   JOURNAL OF CELL BIOLOGY

Alternative direct stem cell derivatives defined by stem cell location and graded Wnt signalling

(2017) Amy Reilein et al.   NATURE CELL BIOLOGY

Combined changes in Wnt signaling response and contact inhibition induce altered proliferation in radiation-treated intestinal crypts

(2016) S.-J. Dunn et al.   MOLECULAR BIOLOGY OF THE CELL

Visualization of a short-range Wnt gradient in the intestinal stem-cell niche

(2016) Henner F. Farin et al.   NATURE

Organoids as an in vitro model of human development and disease

(2016) Aliya Fatehullah et al.   NATURE CELL BIOLOGY

Increased variability in Apc Min /+ intestinal tissue can be measured with microultrasound

(2016) A. Fatehullah et al.   Scientific Reports

Paneth Cell-Rich Regions Separated by a Cluster of Lgr5+ Cells Initiate Crypt Fission in the Intestinal Stem Cell Niche

(2016) Alistair J. Langlands et al.   PLOS BIOLOGY

Sequential cancer mutations in cultured human intestinal stem cells

(2015) Jarno Drost et al.   NATURE

CAMSAP3 orients the apical-to-basal polarity of microtubule arrays in epithelial cells

(2015) Mika Toya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging

(2014) Laila Ritsma et al.   NATURE

Fluorogenic probes for live-cell imaging of the cytoskeleton

(2014) Gražvydas Lukinavičius et al.   NATURE METHODS

Tripartite interactions between Wnt signaling, Notch and Myb for stem/progenitor cell functions during intestinal tumorigenesis

(2014) Markus Germann et al.   Stem Cell Research

Quantification of Crypt and Stem Cell Evolution in the Normal and Neoplastic Human Colon

(2014) Ann-Marie Baker et al.   Cell Reports

The APC Network Regulates the Removal of Mutated Cells from Colonic Crypts

(2014) Je-Hoon Song et al.   Cell Reports

Interactions and functions of the adenomatous polyposis coli (APC) protein at a glance

(2013) S. Nelson et al.   JOURNAL OF CELL SCIENCE

Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny

(2013) Xiaolei Yin et al.   NATURE METHODS

Cell and tissue polarity in the intestinal tract during tumourigenesis: cells still know the right way up, but tissue organization is lost

(2013) A. Fatehullah et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Computational Models Reveal a Passive Mechanism for Cell Migration in the Crypt

(2013) Sara-Jane Dunn et al.   PLoS One

Defining Stem Cell Dynamics in Models of Intestinal Tumor Initiation

(2013) L. Vermeulen et al.   SCIENCE

Chaste: An Open Source C++ Library for Computational Physiology and Biology

(2013) Gary R. Mirams et al.   PLoS Computational Biology

Apical movement during interkinetic nuclear migration is a two-step process

(2012) Philip C. Spear et al.   DEVELOPMENTAL BIOLOGY

Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systems

(2012) S. A. Nelson et al.   Disease Models & Mechanisms

The tumor suppressorApccontrols planar cell polarities central to gut homeostasis

(2012) Julien Bellis et al.   JOURNAL OF CELL BIOLOGY

Cell dynamics in fetal intestinal epithelium: implications for intestinal growth and morphogenesis

(2011) A. S. Grosse et al.   DEVELOPMENT

Expansion of Paneth Cell Population in Response to Enteric Salmonella enterica Serovar Typhimurium Infection

(2011) Nadine R. Martinez Rodriguez et al.   INFECTION AND IMMUNITY

Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells

(2010) Hugo J. Snippert et al.   CELL

Spindle Orientation Bias in Gut Epithelial Stem Cell Compartments Is Lost in Precancerous Tissue

(2010) Aaron J. Quyn et al.   Cell Stem Cell

Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1

(2010) Kyoko Okada et al.   JOURNAL OF CELL BIOLOGY

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Intestinal Stem Cell Replacement Follows a Pattern of Neutral Drift

(2010) C. Lopez-Garcia et al.   SCIENCE

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Adenomatous polyposis coli is required for early events in the normal growth and differentiation of the developing cerebral cortex

(2009) Uladzislau Ivaniutsin et al.   Neural Development

Regulation of Neurogenesis by Interkinetic Nuclear Migration through an Apical-Basal Notch Gradient

(2008) Filippo Del Bene et al.   CELL

Cell regulation by the Apc protein

(2008) Brooke M McCartney et al.   CURRENT OPINION IN CELL BIOLOGY

Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells

(2008) Adlen Foudi et al.   NATURE BIOTECHNOLOGY