Multiple E2 ubiquitin-conjugating enzymes regulate human cytomegalovirus US2-mediated immunoreceptor downregulation

Recent advances in viral evasion of the MHC Class I processing pathway

(2016) Anouk BC Schuren et al.   CURRENT OPINION IN IMMUNOLOGY

Identifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class I

(2015) D.J.H. van den Boomen et al.   MOLECULAR IMMUNOLOGY

IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation

(2015) Shengyi Sun et al.   NATURE CELL BIOLOGY

Viral immune evasion: Lessons in MHC class I antigen presentation

(2015) Michael L. van de Weijer et al.   SEMINARS IN IMMUNOLOGY

Plasma Membrane Profiling Defines an Expanded Class of Cell Surface Proteins Selectively Targeted for Degradation by HCMV US2 in Cooperation with UL141

(2015) Jye-Lin Hsu et al.   PLoS Pathogens

Dimeric Ube2g2 simultaneously engages donor and acceptor ubiquitins to form Lys48-linked ubiquitin chains

(2014) Weixiao Liu et al.   EMBO JOURNAL

Ube2g2-gp78-mediated HERP polyubiquitylation is involved in ER stress recovery

(2014) L. Yan et al.   JOURNAL OF CELL SCIENCE

The pathogenesis of human cytomegalovirus

(2014) Paul Griffiths et al.   JOURNAL OF PATHOLOGY

Herp coordinates compartmentalization and recruitment of HRD1 and misfolded proteins for ERAD

(2014) Julia Leitman et al.   MOLECULAR BIOLOGY OF THE CELL

TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I

(2014) D. J. H. van den Boomen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation

(2014) Michael L. van de Weijer et al.   Nature Communications

Diverse immune evasion strategies by human cytomegalovirus

(2012) Vanessa Noriega et al.   IMMUNOLOGIC RESEARCH

Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet–associated endoplasmic reticulum membranes

(2012) Youngah Jo et al.   MOLECULAR BIOLOGY OF THE CELL

Human cytomegalovirus US3 modulates destruction of MHC class I molecules

(2012) Vanessa M. Noriega et al.   MOLECULAR IMMUNOLOGY

The Mammalian Endoplasmic Reticulum-Associated Degradation System

(2012) J. A. Olzmann et al.   Cold Spring Harbor Perspectives in Biology

Defining human ERAD networks through an integrative mapping strategy

(2011) John C. Christianson et al.   NATURE CELL BIOLOGY

Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8

(2011) Y. Jo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tetra-glutamic acid residues adjacent to Lys248 in HMG-CoA reductase are critical for the ubiquitination mediated by gp78 and UBE2G2

(2010) Honghua Miao et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

The p97 ATPase Dislocates MHC Class I Heavy Chain in US2-expressing Cells via a Ufd1-Npl4-independent Mechanism

(2010) Nia Soetandyo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The HCMV membrane glycoprotein US10 selectively targets HLA-G for degradation

(2010) Boyoun Park et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Stabilization of an E3 Ligase-E2-Ubiquitin Complex Increases Cell Surface MHC Class I Expression

(2010) L. M. Duncan et al.   JOURNAL OF IMMUNOLOGY

The TRC8 Ubiquitin Ligase Is Sterol Regulated and Interacts with Lipid and Protein Biosynthetic Pathways

(2010) J. P. Lee et al.   MOLECULAR CANCER RESEARCH

Evasion of CD8+ T Cells Is Critical for Superinfection by Cytomegalovirus

(2010) S. G. Hansen et al.   SCIENCE

Rapid E2-E3 Assembly and Disassembly Enable Processive Ubiquitylation of Cullin-RING Ubiquitin Ligase Substrates

(2009) Gary Kleiger et al.   CELL

TRAM1 Participates in Human Cytomegalovirus US2- and US11-mediated Dislocation of an Endoplasmic Reticulum Membrane Glycoprotein

(2009) Kristina Oresic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER

(2009) Helen R. Stagg et al.   JOURNAL OF CELL BIOLOGY

Ube2j2 ubiquitinates hydroxylated amino acids on ER-associated degradation substrates

(2009) Xiaoli Wang et al.   JOURNAL OF CELL BIOLOGY

The E3 Ubiquitin Ligases Hrd1 and gp78 Bind to and Promote Cholera Toxin Retro-Translocation

(2009) Kaleena M. Bernardi et al.   MOLECULAR BIOLOGY OF THE CELL

Allosteric Activation of E2-RING Finger-Mediated Ubiquitylation by a Structurally Defined Specific E2-Binding Region of gp78

(2009) Ranabir Das et al.   MOLECULAR CELL

E2 interaction and dimerization in the crystal structure of TRAF6

(2009) Qian Yin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY