Proline dehydrogenase promotes senescence through the generation of reactive oxygen species

Identification of cellular senescence-specific genes by comparative transcriptomics

(2016) Taiki Nagano et al.   Scientific Reports

Proline biosynthesis augments tumor cell growth and aerobic glycolysis: involvement of pyridine nucleotides

(2015) Wei Liu et al.   Scientific Reports

Cellular senescence and its effector programs

(2014) R. Salama et al.   GENES & DEVELOPMENT

Senescence and aging: the critical roles of p53

(2013) A Rufini et al.   ONCOGENE

P53 Family Members Modulate the Expression of PRODH, but Not PRODH2, via Intronic p53 Response Elements

(2013) Ivan Raimondi et al.   PLoS One

Branched-Chain Amino Acids Enhance Premature Senescence through Mammalian Target of Rapamycin Complex I-Mediated Upregulation of p21 Protein

(2013) Masayuki Nakano et al.   PLoS One

p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa

(2013) Liz J. Valente et al.   Cell Reports

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Cyclin-dependent kinase inhibitor p21Waf1: Contemporary view on its role in senescence and oncogenesis

(2012) V. S. Romanov et al.   BIOCHEMISTRY-MOSCOW

Impaired Insulin/IGF1 Signaling Extends Life Span by Promoting Mitochondrial L-Proline Catabolism to Induce a Transient ROS Signal

(2012) Kim Zarse et al.   Cell Metabolism

E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression

(2012) L. A. Carvajal et al.   GENES & DEVELOPMENT

The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence

(2012) O. Aksoy et al.   GENES & DEVELOPMENT

Expression in Escherichia coli of the catalytic domain of human proline oxidase

(2012) Elena Tallarita et al.   PROTEIN EXPRESSION AND PURIFICATION

Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

(2011) Colleen A. Brady et al.   CELL

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

Proline Oxidase Functions as a Mitochondrial Tumor Suppressor in Human Cancers

(2009) Y. Liu et al.   CANCER RESEARCH

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Analysis of prepulse inhibition in mouse lines overexpressing 22q11.2 orthologues

(2009) Kimberly L. Stark et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The metabolism of proline, a stress substrate, modulates carcinogenic pathways

(2008) James M. Phang et al.   AMINO ACIDS

Free radicals and senescence

(2008) Teng Lu et al.   EXPERIMENTAL CELL RESEARCH