mTORC1 Inhibits NF-κB/NFATc1 Signaling and Prevents Osteoclast Precursor Differentiation, In Vitro and In Mice

Activation of mTORC1 in B Lymphocytes Promotes Osteoclast Formation via Regulation of β-Catenin and RANKL/OPG

(2016) Song Xu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation

(2016) Bo Yan et al.   Nature Communications

Everolimus restrains the paracrine pro-osteoclast activity of breast cancer cells

(2015) Valeria Simone et al.   BMC CANCER

Osteoclast fusion is initiated by a small subset of RANKL-stimulated monocyte progenitors, which can fuse to RANKL-unstimulated progenitors

(2015) Noam Levaot et al.   BONE

The role of osteoclast differentiation and function in skeletal homeostasis

(2015) Kyoji Ikeda et al.   JOURNAL OF BIOCHEMISTRY

Lysosomal pH Plays a Key Role in Regulation of mTOR Activity in Osteoclasts

(2015) Yingwei Hu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

mTORC1 Prevents Preosteoblast Differentiation through the Notch Signaling Pathway

(2015) Bin Huang et al.   PLoS Genetics

The Great Beauty of the osteoclast

(2014) Alfredo Cappariello et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Tsc2 Is a Molecular Checkpoint Controlling Osteoblast Development and Glucose Homeostasis

(2014) R. C. Riddle et al.   MOLECULAR AND CELLULAR BIOLOGY

Alternative pathways of osteoclastogenesis in inflammatory arthritis

(2014) Iannis E. Adamopoulos et al.   Nature Reviews Rheumatology

Osteoclasts: more than ‘bone eaters’

(2014) Julia F. Charles et al.   TRENDS IN MOLECULAR MEDICINE

TSC1 controls macrophage polarization to prevent inflammatory disease

(2014) Linnan Zhu et al.   Nature Communications

Metabolic regulation of osteoclast differentiation and function

(2013) Yoriko Indo et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Alpha-1 antitrypsin reduces ovariectomy-induced bone loss in mice

(2012) Jay J. Cao et al.   Annals of the New York Academy of Sciences

Osteoclast Fusion and Fission

(2012) Ineke D. C. Jansen et al.   CALCIFIED TISSUE INTERNATIONAL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

IL-18 Upregulates the Production of Key Regulators of Osteoclastogenesis from Fibroblast-Like Synoviocytes in Rheumatoid Arthritis

(2012) Wei Zhang et al.   INFLAMMATION

Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function

(2012) Julia F. Charles et al.   JOURNAL OF CLINICAL INVESTIGATION

Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow

(2012) Anna Mansour et al.   JOURNAL OF EXPERIMENTAL MEDICINE

mTOR and the differentiation of mesenchymal stem cells

(2011) X. Xiang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Crosstalk in NF-κB signaling pathways

(2011) Andrea Oeckinghaus et al.   NATURE IMMUNOLOGY

Bone growth during rapamycin therapy in young rats

(2009) Cheryl P Sanchez et al.   BMC Pediatrics

Key factors in mTOR regulation

(2009) Xiaochun Bai et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

NFATc1: Functions in osteoclasts

(2009) Qingxiao Zhao et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Gene expression profile of the bone microenvironment in human fragility fracture bone

(2008) B. Hopwood et al.   BONE

Rapamycin affects early fracture healing in mice

(2008) J H Holstein et al.   BRITISH JOURNAL OF PHARMACOLOGY

NFATc1 Induces Osteoclast Fusion Via Up-Regulation of Atp6v0d2 and the Dendritic Cell-Specific Transmembrane Protein (DC-STAMP)

(2007) Kabsun Kim et al.   MOLECULAR ENDOCRINOLOGY