Article
Endocrinology & Metabolism
Sevval Ozturk, Ibrahim Cuneyit, Fatih Altuntas, Ege Riza Karagur, Aysegul Cort Donmez, Mert Ocak, Mustafa Unal, Mehmet Sarikanat, Baris Ozgur Donmez
Summary: This study aimed to investigate the preventive effects of resveratrol on bone quality deterioration caused by ovariectomy. The results showed that resveratrol improved bone strength and volume, increased osteogenic differentiation, and reduced bone tissue damage. These findings suggest that resveratrol has a protective effect against osteoporosis.
JOURNAL OF BONE AND MINERAL METABOLISM
(2023)
Article
Pharmacology & Pharmacy
Zhiyuan Guan, Zheng Xuanqi, Junxiong Zhu, Wanqiong Yuan, Jialin Jia, Chenggui Zhang, Tiantong Sun, Huijie Leng, Changtao Jiang, Yingsheng Xu, Chunli Song
Summary: Postmenopausal osteoporosis is a common bone metabolic disease, and gut microbiota (GM) imbalance plays an important role in its development. This study found that ovariectomized mice had gut microbiota dysbiosis, and reducing gut microbiota through antibiotic treatment improved bone health. G-protein coupled bile acid receptor and systemic inflammatory factors were identified as key players in bone metabolism.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Sung-Ju Lee, Seon-A Jang, Seong Cheol Kim, Jin Ah Ryuk, Hyunil Ha
Summary: The water extract of Lophatherum gracile leaves inhibits osteoclast differentiation and bone loss, making it a potential candidate for therapy and prevention of postmenopausal osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Francesca Salamanna, Deyanira Contartese, Francesca Veronesi, Lucia Martini, Milena Fini
Summary: Sheep ovariectomy plays a crucial role in osteoporosis research, and the impact of variables such as breed, age, diet, and time after surgery should be monitored. Comparative studies are necessary to minimize the impact of these variables and to better understand bone remodeling. Results showed a significant decline in bone mineral density and structural parameters after 12 months of ovariectomy, with site-specific bone alterations in the lumbar vertebra, femoral neck, and ribs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Sung-Ju Lee, Seon-A Jang, Seong Cheol Kim, Dong Ryun Gu, Hyun Yang, Jin Ah Ryuk, Hyunil Ha
Summary: This study found that Euonymus alatus (Thunb.) Siebold has inhibitory effects on osteoclast differentiation and osteoporosis. Through downregulating the expression of RANKL and interfering with RANKL-mediated signaling pathways, it can inhibit the generation and function of osteoclasts. Additionally, oral administration of the ethanolic extract significantly alleviated bone loss in a mouse model. These findings suggest that E. alatus holds potential as a biotherapeutic candidate for anti-postmenopausal osteoporosis.
Article
Microbiology
Yuan-Wei Zhang, Mu-Min Cao, Ying-Juan Li, Ren-Wang Sheng, Ruo-Lan Zhang, Meng-Ting Wu, Jia-Yu Chi, Rui-Xin Zhou, Yun-Feng Rui
Summary: This study aimed to investigate whether supplementation of Prevotella histicola (Ph) could prevent bone loss in mice with ovariectomy (OVX)-mediated osteoporosis (OP), and explore related mechanisms. The results showed that regular and quantitative perfusion of Ph mitigated the bone loss in mice with OVX-mediated OP and improved gut microbiota disturbance.
Article
Medicine, Research & Experimental
Ra-Yeong Choi, In-Woo Kim, Moongi Ji, Man-Jeong Paik, Eu-Jin Ban, Joon Ha Lee, Jae Sam Hwang, HaeYong Kweon, Minchul Seo
Summary: The ethanol extract of P. brevitarsis larvae (PBE) can inhibit RANKL-induced osteoclast formation and prevent bone loss. PBE decreases tartrate-resistant acid phosphatase activity and the expression of osteoclastogenesis-associated genes and proteins. It also inhibits the phosphorylation of p38 and NF-κB.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Geochemistry & Geophysics
Ewerton Vieira, Marcos Silva, Antonio Maia-Filho, Daniel Ferreira, Jose Figueredo-Silva, Karla Rovaris, Ana Cristina Fialho, Ana Leite-Oliveira, Andre L. Menezes de Oliveira, Maria Gardennia da Fonseca, Josy A. Osajima, Edson C. Da Silva-Filho
Summary: This study introduced a cerium-containing HA material, which exhibited good antimicrobial properties and demonstrated a strong osteogenic effect in bone repair.
Article
Spectroscopy
J. Renwick Beattie, Mark R. Towler
Summary: Pharmacological therapy using bisphosphonates reduces the risk of fracture in osteoporosis by more than just modulating bone mineral density. This study explores the influence of bone active medication on keratin structure in humans through analysis of fingernail clippings. The results suggest that treatment with bisphosphonates reverts damaged protein structure and provides preliminary evidence of a systemic influence of bone active medication on keratin. Further investigation of these effects is warranted.
JOURNAL OF RAMAN SPECTROSCOPY
(2023)
Article
Biotechnology & Applied Microbiology
Zhiqi Zhao, Haibiao Sun, Yongliang Fu, Xingyu Liang, Tao Fan, Xiaoqiong Li, Liying Zhu, Liubei Xu, Xin Wang, Jinjun Li, Xiaoqiang Han
Summary: This study explored the effects of fucoidan on the gut-bone axis in ovariectomized mice with osteoporosis and demonstrated its efficacy in treating osteoporosis. Fucoidan improves bone health by regulating gut microbiota, protecting the intestinal barrier, and altering lipid metabolism.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Tiansong Yang, Qingyong Wang, Yuanyuan Qu, Chuwen Feng, Chaoran Li, Yan Yang, Zhongren Sun, Tahani A. Alahmadi, Sulaiman A. Alharbi, Shengyong Bao
Summary: Rhaponticin has therapeutic potential for osteoporosis in OVX rats, preventing bone density loss and improving bone microarchitecture, while also positively impacting body indices, bone turnover markers, inflammatory markers, and more.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Plant Sciences
Kalpana Patel, S. V. V. S. Ravi Mangu, Shinde Vijay Sukhdeo, Kunal Sharan
Summary: The study aims to investigate the osteo-protective effect of root and leaf ethanolic extract of Sida cordifolia and its underlying mechanism. The results showed that both RE and LE have antioxidant activity and promote osteoblast differentiation by activating ERK, AKT, and CREB signaling pathways, indirectly inhibiting osteoclast differentiation.
Article
Critical Care Medicine
Satoshi Inoue, Kaoru Fujikawa, Miwako Matsuki-Fukushima, Masanori Nakamura
Summary: The study compared the repair process between metaphysis and diaphysis of ovariectomized (OVX) and Sham mice, and analyzed the effects of short-term estrogen administration in OVX mice. The results showed that OVX mice had less medullary callus formation and delayed repair in diaphysis compared to Sham mice. Estrogen administration improved medullary callus formation in the diaphysis, but not in the metaphysis, suggesting different estrogen sensitivities between the sites during bone repair.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2021)
Article
Materials Science, Ceramics
Guian Man, Yixuan Jiang, Xingzhe Wang
Summary: In this study, the phase transition behavior of relaxor ferroelectric PMN-PT single crystals under mechanical load was investigated. It was found that the rhombohedral phase can be transformed to the tetragonal phase under mechanical stress, and the tetragonal phase exhibits structural stability. These findings suggest that the relaxor ferroelectric single crystals have the potential for mechanical controllability.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2022)
Article
Endocrinology & Metabolism
John G. Damrath, Sharon M. Moe, Joseph M. Wallace
Summary: Chronic kidney disease affects bone quality, and treatment with calcimimetics improves tissue-level bone material properties to prevent bone deterioration.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Engineering, Biomedical
Chiara Micheletti, Ariana Hurley, Aurelien Gourrier, Anders Palmquist, Tengteng Tang, Furqan A. Shah, Kathryn Grandfield
Summary: This article provides a new perspective on bone structure, highlighting the ubiquitous presence of mineral ellipsoids in bones and their importance in terms of toughness and strength.
ACTA BIOMATERIALIA
(2022)
Article
Dentistry, Oral Surgery & Medicine
Shariel Sayardoust, Wilhelm Norstedt, Furqan A. Shah
Summary: The study evaluates the long-term impact of alveolar ridge preservation (ARP) on peri-implant health and its relationship with common risk indicators such as smoking and history of periodontitis. The findings suggest that peri-implant health can be maintained for at least 5 years in ARP(+) sites using deproteinized bovine bone mineral xenograft. Smoking is a major risk indicator for peri-implantitis, while the association between history of periodontitis and risk of peri-implantitis remains inconclusive.
CLINICAL AND EXPERIMENTAL DENTAL RESEARCH
(2022)
Review
Engineering, Biomedical
Anders Palmquist, Martina Jolic, Eduard Hryha, Furqan A. Shah
Summary: In the past decade, additive manufacturing technologies, particularly electron beam melting (EBM), have revolutionized the production of biomedical implants. EBM offers faster build rates and a high vacuum environment, making it advantageous for materials susceptible to oxidation and nitrogen pick-up. EBM manufactured implants have shown great potential in skeletal reconstruction, with anatomical mimickry and macro-porous architecture. The personalized design and diverse clinical applications of EBM in skeletal repair and prosthetic rehabilitation are discussed in this review.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Biomedical
Sapir Gershov, Jing Xie, Furqan A. Shah, Keren Shemtov-Yona, Daniel Rittel
Summary: A novel numerical spatio-temporal model is developed to assess the interaction between the implant, surrounding bone, and evolving interface. The study shows that load transfer between the bone and implant is hindered until the interface develops into a solid continuous bone, regardless of the BIC.
ACTA BIOMATERIALIA
(2022)
Review
Multidisciplinary Sciences
Martina Jolic, Sonali Sharma, Anders Palmquist, Furqan A. Shah
Summary: The success of metal implants in rehabilitation is due to osseointegration, the direct connection between living bone and the implant. Removal torque measurement can assess the extent of biomechanical anchorage between the implant and bone. Various pharmacological agents have been evaluated for their impact on osseointegration, with some substances showing positive effects on removal torque and others showing adverse effects. Factors such as bone quality play a role in the biomechanical anchorage of metal implants, and questions regarding drug metabolism, dosage, and treatment interruption remain unanswered.
Article
Engineering, Biomedical
Furqan A. Shah, Martina Jolic, Chiara Micheletti, Omar Omar, Birgitta Norlindh, Lena Emanuelsson, Hakan Engqvist, Thomas Engstrand, Anders Palmquist, Peter Thomsen
Summary: Calcium phosphates (CaP) are important biomaterials for bone regeneration. This study demonstrates how a multi-component CaP formulation can guide bone formation beyond the normal physiological range. The study shows successful bone formation and remodeling in sheep models using this CaP formulation, and the presence of woven bone and vascularized lamellar bone in the pores of the CaP material.
BIOACTIVE MATERIALS
(2023)
Article
Endocrinology & Metabolism
Chiara Micheletti, Liza-Anastasia DiCecco, Cecilia Larsson Wexell, Dakota M. Binkley, Anders Palmquist, Kathryn Grandfield, Furqan A. Shah
Summary: This study investigates the interface between necrotic bone and bacteria in medication-related osteonecrosis of the jaw (MRONJ) using a multimodal and multiscale characterization approach. The findings suggest that the bone-bacteria interface originates not only from uncontrolled mineralization but also from the direct action of bacteria degrading the bone matrix.
Article
Microscopy
Furqan A. Shah
Summary: The lacuno-canalicular space of apoptotic osteocytes in ageing bone becomes mineralised, forming hypermineralised osteocyte lacunae that indicate impaired bone function. The mineralised apoptotic debris in the lacuno-canalicular space consists of micrometre-sized nodules of magnesium-rich, carbonated apatite. Additionally, rhomboidal nodules of magnesium whitlockite have been observed in human alveolar bone exposed to the bisphosphonate alendronate. This study provides evidence of Mg-whitlockite formation in alveolar bone exposed to zoledronic acid.
Article
Multidisciplinary Sciences
Furqan Shah
Summary: This study investigates the differences in composition of acid phosphate, carbonate, hydroxyl, iron, and magnesium content between pigmented incisor enamel and unpigmented molar enamel of Sprague Dawley rats. The results reveal that iron-rich pigmented enamel has higher mineral crystallinity, higher levels of acid phosphate and hydroxyl, and no presence of iron oxides or oxy(hydroxides). These findings provide new insights into enamel biomineralization and the functional differences of ameloblasts between incisors and molars in rodents.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Biomedical
Heithem Ben Amara, Diana C. Martinez, Furqan A. Shah, Anna Johansson Loo, Lena Emanuelsson, Birgitta Norlindh, Regine Willumeit-Romer, Tomasz Plocinski, Wojciech Swieszkowski, Anders Palmquist, Omar Omar, Peter Thomsen
Summary: Using a rat soft tissue model, the researchers found that magnesium (Mg) implants exacerbated initial inflammation but also initiated chemotaxis and upregulated immunomodulatory markers, leading to tissue repair. The understanding of the relationship between Mg material properties and cellular processes provides a basis for interpretation of clinical observations and future improvements in Mg implants.
BIOACTIVE MATERIALS
(2023)
Review
Endocrinology & Metabolism
Mari Sato, Furqan A. A. Shah
Summary: In recent years, there has been an evolution of imaging technologies for visualising cells and investigating their interactions with other cells, anatomical structures, and biomaterials. Resin cast etching (RCE) is a simple technique for observing the osteocyte lacuno-canalicular network in bone using scanning electron microscopy. RCE can be used to investigate various quantitative and qualitative parameters, including size and density of osteocytes, arrangement of osteocytes and canaliculi, and communication between osteocytes and implant surfaces. It has applications in studying bone-related diseases and evaluating the osseointegration potential of different materials.
CALCIFIED TISSUE INTERNATIONAL
(2023)