Glucagon and Insulin Cooperatively Stimulate Fibroblast Growth Factor 21 Gene Transcription by Increasing the Expression of Activating Transcription Factor 4

Understanding the Physiology of FGF21

(2016) Ffolliott Martin Fisher et al.   Annual Review of Physiology

Targeting cAMP/PKA pathway for glycemic control and type 2 diabetes therapy

(2016) Haihua Yang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Metabolic Responses to Dietary Protein Restriction Require an Increase in FGF21 that Is Delayed by the Absence of GCN2

(2016) Thomas Laeger et al.   Cell Reports

Pathogenesis of Selective Insulin Resistance in Isolated Hepatocytes

(2015) Joshua R. Cook et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21

(2015) Bryn M. Owen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

FGF21 Revolutions: Recent Advances Illuminating FGF21 Biology and Medicinal Properties

(2015) Alexei Kharitonenkov et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly

(2015) Carmela Sidrauski et al.   eLife

Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding

(2014) K. R. Markan et al.   DIABETES

Nrf2 induces fibroblast growth factor 21 in diabetic mice

(2014) Yuki Furusawa et al.   GENES TO CELLS

Fibroblast Growth Factor 21 Is Regulated by the IRE1α-XBP1 Branch of the Unfolded Protein Response and Counteracts Endoplasmic Reticulum Stress-induced Hepatic Steatosis

(2014) Shan Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FGF21 is an endocrine signal of protein restriction

(2014) Thomas Laeger et al.   JOURNAL OF CLINICAL INVESTIGATION

Glucagon Stimulates Hepatic FGF21 Secretion through a PKA- and EPAC-Dependent Posttranscriptional Mechanism

(2014) Holly A. Cyphert et al.   PLoS One

Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21

(2014) M. Cornu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel Bcr-Abl-mTOR-eIF4A axis regulates IRES-mediated translation of LEF-1

(2014) B. P. Tsai et al.   Open Biology

Diacylglycerol kinase θ couples farnesoid X receptor-dependent bile acid signalling to Akt activation and glucose homoeostasis in hepatocytes

(2013) Kai Cai et al.   BIOCHEMICAL JOURNAL

Internal ribosome entry site-mediated translational regulation of ATF4 splice variant in mammalian unfolded protein response

(2013) Ching-Ping Chan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Human Insulin Resistance Is Associated With Increased Plasma Levels of 12 -Hydroxylated Bile Acids

(2013) R. A. Haeusler et al.   DIABETES

FGF21 mediates the lipid metabolism response to amino acid starvation

(2013) Ana Luísa De Sousa-Coelho et al.   JOURNAL OF LIPID RESEARCH

Cyclic AMP sensor EPAC proteins and energy homeostasis

(2013) Muayad Almahariq et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation

(2012) Ana Luísa De Sousa-Coelho et al.   BIOCHEMICAL JOURNAL

Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

(2012) M. J. Potthoff et al.   GENES & DEVELOPMENT

Activation of the Farnesoid X Receptor Induces Hepatic Expression and Secretion of Fibroblast Growth Factor 21

(2012) Holly A. Cyphert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase

(2012) J. L. Owen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

(2011) Jessica L. Yecies et al.   Cell Metabolism

Glucose and Insulin Induction of Bile Acid Synthesis

(2011) Tiangang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Fibroblast Growth Factor 21 in Obesity and Nonalcoholic Fatty Liver Disease

(2010) Jody Dushay et al.   GASTROENTEROLOGY

Hepatic FoxO1 Ablation Exacerbates Lipid Abnormalities during Hyperglycemia

(2010) Rebecca A. Haeusler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rap1 Promotes Multiple Pancreatic Islet Cell Functions and Signals through Mammalian Target of Rapamycin Complex 1 to Enhance Proliferation

(2010) Patrick Kelly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The metabolic actions of glucagon revisited

(2010) Kirk M. Habegger et al.   Nature Reviews Endocrinology

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

(2010) Shijie Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of FOXO in the regulation of metabolism

(2009) Danielle N. Gross et al.   Current Diabetes Reports

Ursodeoxycholic acid induces glutathione synthesis through activation of PI3K/Akt pathway in HepG2 cells

(2008) Sakiko Arisawa et al.   BIOCHEMICAL PHARMACOLOGY

The transcriptomic signature of fasting murine liver

(2008) Milka Sokolovic et al.   BMC GENOMICS

Inactivation of Hepatic Foxo1 by Insulin Signaling Is Required for Adaptive Nutrient Homeostasis and Endocrine Growth Regulation

(2008) Xiaocheng C. Dong et al.   Cell Metabolism

Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans

(2008) X. Zhang et al.   DIABETES

FGF21 is an Akt-regulated myokine

(2008) Yasuhiro Izumiya et al.   FEBS LETTERS

Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress

(2008) Irina M Bochkis et al.   NATURE MEDICINE