How activating mutations affect MEK1 regulation and function

Divergent effects of intrinsically active MEK variants on developmental Ras signaling

(2017) Yogesh Goyal et al.   NATURE GENETICS

In vivo severity ranking of Ras pathway mutations associated with developmental disorders

(2017) Granton A. Jindal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RASopathies: unraveling mechanisms with animal models

(2015) G. A. Jindal et al.   Disease Models & Mechanisms

MAP Kinase Modules: The Excursion Model and the Steps that Count

(2014) Alexander T. Piala et al.   BIOPHYSICAL JOURNAL

Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling

(2014) Jacob R. Haling et al.   CANCER CELL

COSMIC: exploring the world's knowledge of somatic mutations in human cancer

(2014) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

The RASopathies

(2013) Katherine A. Rauen   Annual Review of Genomics and Human Genetics

MEK genomics in development and disease

(2012) J. L. Bromberg-White et al.   Briefings in Functional Genomics

Continual low-level MEK inhibition ameliorates cardio-facio-cutaneous phenotypes in zebrafish

(2012) C. Anastasaki et al.   Disease Models & Mechanisms

Noonan syndrome gain-of-function mutations in NRAS cause zebrafish gastrulation defects

(2011) V. Runtuwene et al.   Disease Models & Mechanisms

A Dynamic Noise Level Algorithm for Spectral Screening of Peptide MS/MS Spectra

(2010) Hua Xu et al.   BMC BIOINFORMATICS

Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors

(2009) Thierry O. Fischmann et al.   BIOCHEMISTRY

Kinase-activating and kinase-impaired cardio-facio-cutaneous syndrome alleles have activity during zebrafish development and are sensitive to small molecule inhibitors

(2009) C. Anastasaki et al.   HUMAN MOLECULAR GENETICS

Distinct functions for ERK1 and ERK2 in cell migration processes during zebrafish gastrulation

(2008) S.F. Gabby Krens et al.   DEVELOPMENTAL BIOLOGY