Differential catalytic promiscuity of the alkaline phosphatase superfamily bimetallo core reveals mechanistic features underlying enzyme evolution

Crystal structure of the human alkaline sphingomyelinase provides insights into substrate recognition

(2017) Alexei Gorelik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolution of Enzyme Superfamilies: Comprehensive Exploration of Sequence–Function Relationships

(2016) F. Baier et al.   BIOCHEMISTRY

Large-Scale Analysis Exploring Evolution of Catalytic Machineries and Mechanisms in Enzyme Superfamilies

(2016) Nicholas Furnham et al.   JOURNAL OF MOLECULAR BIOLOGY

Mechanistic and Evolutionary Insights from Comparative Enzymology of Phosphomonoesterases and Phosphodiesterases across the Alkaline Phosphatase Superfamily

(2016) Fanny Sunden et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The physiology and habitat of the last universal common ancestor

(2016) Madeline C. Weiss et al.   Nature Microbiology

Expanding the Enzyme Universe: Accessing Non-Natural Reactions by Mechanism-Guided Directed Evolution

(2015) Hans Renata et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Diversity in protein domain superfamilies

(2015) Sayoni Das et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Assessing the prediction fidelity of ancestral reconstruction by a library approach

(2015) Hagit Bar-Rogovsky et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Extensive site-directed mutagenesis reveals interconnected functional units in the alkaline phosphatase active site

(2015) Fanny Sunden et al.   eLife

Probing the Origins of Catalytic Discrimination between Phosphate and Sulfate Monoester Hydrolysis: Comparative Analysis of Alkaline Phosphatase and Protein Tyrosine Phosphatases

(2014) Logan D. Andrews et al.   BIOCHEMISTRY

Enzyme Promiscuity: Engine of Evolutionary Innovation

(2014) Chetanya Pandya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Site-Directed Mutagenesis Maps Interactions That Enhance Cognate and Limit Promiscuous Catalysis by an Alkaline Phosphatase Superfamily Phosphodiesterase

(2013) Helen Wiersma-Koch et al.   BIOCHEMISTRY

Catalytic mechanisms for phosphotriesterases

(2012) Andrew N. Bigley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Efficient, crosswise catalytic promiscuity among enzymes that catalyze phosphoryl transfer

(2012) Mark F. Mohamed et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Reconstruction of Ancestral Metabolic Enzymes Reveals Molecular Mechanisms Underlying Evolutionary Innovation through Gene Duplication

(2012) Karin Voordeckers et al.   PLOS BIOLOGY

Biological Phosphoryl-Transfer Reactions: Understanding Mechanism and Catalysis

(2011) Jonathan K. Lassila et al.   Annual Review of Biochemistry

Divergence of Chemical Function in the Alkaline Phosphatase Superfamily: Structure and Mechanism of the P−C Bond Cleaving Enzyme Phosphonoacetate Hydrolase

(2011) Alexander Kim et al.   BIOCHEMISTRY

The Enzyme Function Initiative

(2011) John A. Gerlt et al.   BIOCHEMISTRY

A systematic identification of Kolobok superfamily transposons in Trichomonas vaginalis and sequence analysis on related transposases

(2011) Qingshu Meng et al.   Journal of Genetics and Genomics

High-Resolution Analysis of Zn2+ Coordination in the Alkaline Phosphatase Superfamily by EXAFS and X-ray Crystallography

(2011) Elena Bobyr et al.   JOURNAL OF MOLECULAR BIOLOGY

Catalytic Proficiency: The Extreme Case of S–O Cleaving Sulfatases

(2011) David R. Edwards et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal structure of autotaxin and insight into GPCR activation by lipid mediators

(2011) Hiroshi Nishimasu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

X-Ray Structure Reveals a New Class and Provides Insight into Evolution of Alkaline Phosphatases

(2011) Subhash C. Bihani et al.   PLoS One

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective

(2010) Olga Khersonsky and Dan S. Tawfik   Annual Review of Biochemistry

What makes an enzyme promiscuous?

(2010) Ann Babtie et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

An efficient, multiply promiscuous hydrolase in the alkaline phosphatase superfamily

(2010) B. van Loo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Efficient Catalytic Promiscuity for Chemically Distinct Reactions

(2009) Ann C. Babtie et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Functional Annotation and Three-Dimensional Structure of Dr0930 fromDeinococcus radiodurans, a Close Relative of Phosphotriesterase in the Amidohydrolase Superfamily†‡

(2009) Dao Feng Xiang et al.   BIOCHEMISTRY

Mapping catalytic promiscuity in the alkaline phosphatase superfamily

(2009) Stefanie Jonas et al.   PURE AND APPLIED CHEMISTRY

Arginine Coordination in Enzymatic Phosphoryl Transfer: Evaluation of the Effect of Arg166 Mutations inEscherichia coliAlkaline Phosphatase†‡

(2008) Patrick J. O’Brien et al.   BIOCHEMISTRY

Promiscuous Sulfatase Activity and Thio-Effects in a Phosphodiesterase of the Alkaline Phosphatase Superfamily†

(2008) Jonathan K. Lassila et al.   BIOCHEMISTRY

A New Member of the Alkaline Phosphatase Superfamily with a Formylglycine Nucleophile: Structural and Kinetic Characterisation of a Phosphonate Monoester Hydrolase/Phosphodiesterase from Rhizobium leguminosarum

(2008) Stefanie Jonas et al.   JOURNAL OF MOLECULAR BIOLOGY

Comparative Enzymology in the Alkaline Phosphatase Superfamily to Determine the Catalytic Role of an Active-Site Metal Ion

(2008) Jesse G. Zalatan et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Basis for Natural Lactonase and Promiscuous Phosphotriesterase Activities

(2008) Mikael Elias et al.   JOURNAL OF MOLECULAR BIOLOGY

Efficient Catalytic Promiscuity in an Enzyme Superfamily: An Arylsulfatase Shows a Rate Acceleration of 1013for Phosphate Monoester Hydrolysis

(2008) Luis F. Olguin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY