A dual agonist of farnesoid X receptor (FXR) and the G protein–coupled receptor TGR5, INT-767, reverses age-related kidney disease in mice

The age-associated loss of ischemic preconditioning in the kidney is accompanied by mitochondrial dysfunction, increased protein acetylation and decreased autophagy

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Aging Biology in the Kidney

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Mitochondrial electron transport chain functions in long-lived Ames dwarf mice

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G Protein-Coupled Bile Acid Receptor TGR5 Activation Inhibits Kidney Disease in Obesity and Diabetes

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Glomerular Aging and Focal Global Glomerulosclerosis: A Podometric Perspective

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Chronic kidney disease and the aging population

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Dual Activation of the Bile Acid Nuclear Receptor FXR and G-Protein-Coupled Receptor TGR5 Protects Mice against Atherosclerosis

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The Association Between Age and Nephrosclerosis on Renal Biopsy Among Healthy Adults

(2013) Andrew D. Rule   ANNALS OF INTERNAL MEDICINE

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

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Bile Acid Receptor Activation Modulates Hepatic Monocyte Activity and Improves Nonalcoholic Fatty Liver Disease

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Pathophysiology of the aging kidney and therapeutic interventions

(2012) Keizo Kanasaki et al.   HYPERTENSION RESEARCH

The implications of anatomical and functional changes of the aging kidney: with an emphasis on the glomeruli

(2012) Richard J. Glassock et al.   KIDNEY INTERNATIONAL

Aging and the kidney

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Dedifferentiation of Immortalized Human Podocytes in Response to Transforming Growth Factor- : A Model for Diabetic Podocytopathy

(2011) M. Herman-Edelstein et al.   DIABETES

Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2 −/− (Abcb4 −/− ) mouse cholangiopathy model by promoting biliary HCO 3− output

(2011) Anna Baghdasaryan et al.   HEPATOLOGY

Kidney aging—inevitable or preventable?

(2011) Devasmita Choudhury et al.   Nature Reviews Nephrology

Aging and Physiological Changes of the Kidneys Including Changes in Glomerular Filtration Rate

(2011) Carlos G. Musso et al.   NEPHRON PHYSIOLOGY

Insulin Signaling to the Glomerular Podocyte Is Critical for Normal Kidney Function

(2010) Gavin I. Welsh et al.   Cell Metabolism

Diabetic Nephropathy Is Accelerated by Farnesoid X Receptor Deficiency and Inhibited by Farnesoid X Receptor Activation in a Type 1 Diabetes Model

(2010) X. X. Wang et al.   DIABETES

Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

(2010) Shinji Kume et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional Characterization of the Semisynthetic Bile Acid Derivative INT-767, a Dual Farnesoid X Receptor and TGR5 Agonist

(2010) G. Rizzo et al.   MOLECULAR PHARMACOLOGY

Chronic Kidney Disease in Older People: Physiology, Pathology or Both?

(2010) Ahmed H. Abdelhafiz et al.   NEPHRON CLINICAL PRACTICE

Genetic analysis of albuminuria in aging mice and concordance with loci for human diabetic nephropathy found in a genome-wide association scan

(2009) Shirng-Wern Tsaih et al.   KIDNEY INTERNATIONAL

Genetic Suppression of GH-IGF-1 Activity, Combined with Lifelong Caloric Restriction, Prevents Age-Related Renal Damage and Prolongs the Life Span in Rats

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