A dual agonist of farnesoid X receptor (FXR) and the G protein–coupled receptor TGR5, INT-767, reverses age-related kidney disease in mice
出版年份 2017 全文链接
标题
A dual agonist of farnesoid X receptor (FXR) and the G protein–coupled receptor TGR5, INT-767, reverses age-related kidney disease in mice
作者
关键词
-
出版物
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 292, Issue 29, Pages 12018-12024
出版商
American Society for Biochemistry & Molecular Biology (ASBMB)
发表日期
2017-06-09
DOI
10.1074/jbc.c117.794982
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- The age-associated loss of ischemic preconditioning in the kidney is accompanied by mitochondrial dysfunction, increased protein acetylation and decreased autophagy
- (2017) Stanislovas S. Jankauskas et al. Scientific Reports
- Aging Biology in the Kidney
- (2016) Markus Bitzer et al. ADVANCES IN CHRONIC KIDNEY DISEASE
- Mitochondrial electron transport chain functions in long-lived Ames dwarf mice
- (2016) Kashyap B. Choksi et al. Aging-US
- G Protein-Coupled Bile Acid Receptor TGR5 Activation Inhibits Kidney Disease in Obesity and Diabetes
- (2015) X. X. Wang et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Glomerular Aging and Focal Global Glomerulosclerosis: A Podometric Perspective
- (2015) J. B. Hodgin et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Chronic kidney disease and the aging population
- (2014) M. Tonelli et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Dual Activation of the Bile Acid Nuclear Receptor FXR and G-Protein-Coupled Receptor TGR5 Protects Mice against Atherosclerosis
- (2014) Shinobu Miyazaki-Anzai et al. PLoS One
- The Association Between Age and Nephrosclerosis on Renal Biopsy Among Healthy Adults
- (2013) Andrew D. Rule ANNALS OF INTERNAL MEDICINE
- The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling
- (2013) Laurent Mouchiroud et al. CELL
- Bile Acid Receptor Activation Modulates Hepatic Monocyte Activity and Improves Nonalcoholic Fatty Liver Disease
- (2013) Rachel H. McMahan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pathophysiology of the aging kidney and therapeutic interventions
- (2012) Keizo Kanasaki et al. HYPERTENSION RESEARCH
- The implications of anatomical and functional changes of the aging kidney: with an emphasis on the glomeruli
- (2012) Richard J. Glassock et al. KIDNEY INTERNATIONAL
- Aging and the kidney
- (2011) Norberto Perico et al. CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
- Dedifferentiation of Immortalized Human Podocytes in Response to Transforming Growth Factor- : A Model for Diabetic Podocytopathy
- (2011) M. Herman-Edelstein et al. DIABETES
- Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2 −/− (Abcb4 −/− ) mouse cholangiopathy model by promoting biliary HCO 3− output
- (2011) Anna Baghdasaryan et al. HEPATOLOGY
- Kidney aging—inevitable or preventable?
- (2011) Devasmita Choudhury et al. Nature Reviews Nephrology
- Aging and Physiological Changes of the Kidneys Including Changes in Glomerular Filtration Rate
- (2011) Carlos G. Musso et al. NEPHRON PHYSIOLOGY
- Insulin Signaling to the Glomerular Podocyte Is Critical for Normal Kidney Function
- (2010) Gavin I. Welsh et al. Cell Metabolism
- Diabetic Nephropathy Is Accelerated by Farnesoid X Receptor Deficiency and Inhibited by Farnesoid X Receptor Activation in a Type 1 Diabetes Model
- (2010) X. X. Wang et al. DIABETES
- Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney
- (2010) Shinji Kume et al. JOURNAL OF CLINICAL INVESTIGATION
- Functional Characterization of the Semisynthetic Bile Acid Derivative INT-767, a Dual Farnesoid X Receptor and TGR5 Agonist
- (2010) G. Rizzo et al. MOLECULAR PHARMACOLOGY
- Chronic Kidney Disease in Older People: Physiology, Pathology or Both?
- (2010) Ahmed H. Abdelhafiz et al. NEPHRON CLINICAL PRACTICE
- Genetic analysis of albuminuria in aging mice and concordance with loci for human diabetic nephropathy found in a genome-wide association scan
- (2009) Shirng-Wern Tsaih et al. KIDNEY INTERNATIONAL
- Genetic Suppression of GH-IGF-1 Activity, Combined with Lifelong Caloric Restriction, Prevents Age-Related Renal Damage and Prolongs the Life Span in Rats
- (2008) Yan Zha et al. AMERICAN JOURNAL OF NEPHROLOGY
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