Cellular FLIP long isoform (cFLIPL)–IKKα interactions inhibit IRF7 activation, representing a new cellular strategy to inhibit IFNα expression

TSG-6 Downregulates IFN-Alpha and TNF-Alpha Expression by Suppressing IRF7 Phosphorylation in Human Plasmacytoid Dendritic Cells

(2017) L. Kui et al.   MEDIATORS OF INFLAMMATION

Distinct Activation Mechanisms of NF-κB Regulator Inhibitor of NF-κB Kinase (IKK) by Isoforms of the Cell Death Regulator Cellular FLICE-like Inhibitory Protein (cFLIP)

(2016) Mehdi Baratchian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

cFLIPLInterrupts IRF3–CBP–DNA Interactions To Inhibit IRF3-Driven Transcription

(2016) Lauren T. Gates et al.   JOURNAL OF IMMUNOLOGY

Interferon regulatory factor 3 is a key regulation factor for inducing the expression of SAMHD1 in antiviral innate immunity

(2016) Shen Yang et al.   Scientific Reports

Interferon regulatory factors: at the crossroads of immunity, metabolism, and disease

(2015) Guang-Nian Zhao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

TRIM35 negatively regulates TLR7- and TLR9-mediated type I interferon production by targeting IRF7

(2015) Yanming Wang et al.   FEBS LETTERS

TGF-β1 inhibits the production of IFN in response to CpG DNA via ubiquitination of TNF receptor-associated factor (TRAF) 6

(2015) Yoshikazu Naiki et al.   Innate Immunity

Aryl Hydrocarbon Receptor Interacting Protein Targets IRF7 to Suppress Antiviral Signaling and the Induction of Type I Interferon

(2015) Qinjie Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Interferons and viruses: an evolutionary arms race of molecular interactions

(2015) Hans-Heinrich Hoffmann et al.   TRENDS IN IMMUNOLOGY

TRIM26 Negatively Regulates Interferon-β Production and Antiviral Response through Polyubiquitination and Degradation of Nuclear IRF3

(2015) Peng Wang et al.   PLoS Pathogens

Serum amyloid A induces interleukin-33 expression through an IRF7-dependent pathway

(2014) Lei Sun et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Recruitment of Phosphatase PP2A by RACK1 Adaptor Protein Deactivates Transcription Factor IRF3 and Limits Type I Interferon Signaling

(2014) Lingyun Long et al.   IMMUNITY

HIV-2 Vpx Protein Interacts with Interferon Regulatory Factor 5 (IRF5) and Inhibits Its Function

(2014) Xiaogang Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type I Interferon in the Pathogenesis of Lupus

(2014) M. K. Crow   JOURNAL OF IMMUNOLOGY

IRAK4 Dimerization and trans -Autophosphorylation Are Induced by Myddosome Assembly

(2014) Ryan Ferrao et al.   MOLECULAR CELL

c-FLIP-Short Reduces Type I Interferon Production and Increases Viremia with Coxsackievirus B3

(2014) Iwona A. Buskiewicz et al.   PLoS One

c-FLIP Protects Eosinophils from TNF-α-Mediated Cell Death In Vivo

(2014) Claire Gordy et al.   PLoS One

Type I Interferon in Human Autoimmunity

(2014) Timothy B. Niewold   Frontiers in Immunology

Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation

(2013) Y-H Wu et al.   CELL DEATH AND DIFFERENTIATION

IRF5, IRF8, and IRF7 in human pDCs - the good, the bad, and the insignificant?

(2013) Karin Pelka et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Negative Regulation of Nmi on Virus-Triggered Type I IFN Production by Targeting IRF7

(2013) J. Wang et al.   JOURNAL OF IMMUNOLOGY

Human Parainfluenza Virus Type 2 V Protein Inhibits TRAF6-Mediated Ubiquitination of IRF7 To Prevent TLR7- and TLR9-Dependent Interferon Induction

(2013) Y. Kitagawa et al.   JOURNAL OF VIROLOGY

Inhibition of interferon gene activation by death-effector domain-containing proteins from the molluscum contagiosum virus

(2013) C. M. H. Randall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon regulatory factor 7 (IRF7) is required for the optimal initial control but not subsequent clearance of lymphocytic choriomeningitis virus infection in mice

(2013) Wen Li et al.   VIROLOGY

Aberrant Type I Interferon Regulation in Autoimmunity: Opposite Directions in MS and SLE, Shaped by Evolution and Body Ecology

(2013) Anthony T. Reder et al.   Frontiers in Immunology

Spi-B is critical for plasmacytoid dendritic cell function and development

(2012) I. Sasaki et al.   BLOOD

Induction of IFNα or IL-12 depends on differentiation of THP-1 cells in dengue infections without and with antibody enhancement

(2012) Rong-Fu Chen et al.   BMC INFECTIOUS DISEASES

The transcriptional regulator NAB2 reveals a two-step induction of TRAIL in activated plasmacytoid DCs

(2012) Melania Balzarolo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mitochondrial Transcription Factor A Serves as a Danger Signal by Augmenting Plasmacytoid Dendritic Cell Responses to DNA

(2012) M. W. Julian et al.   JOURNAL OF IMMUNOLOGY

Activation of Interferon Regulatory Factor 5 by Site Specific Phosphorylation

(2012) Hui-Chen Chang Foreman et al.   PLoS One

Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathway

(2011) B. W. Higgs et al.   ANNALS OF THE RHEUMATIC DISEASES

Targeting interferon regulatory factors to inhibit activation of the type I IFN response: Implications for treatment of autoimmune disorders

(2011) Susan E. Sweeney   CELLULAR IMMUNOLOGY

IRF7: activation, regulation, modification and function

(2011) S Ning et al.   GENES AND IMMUNITY

Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon–mediated immunity

(2011) Adrian Tun-Kyi et al.   NATURE IMMUNOLOGY

The TRAF-associated protein TANK facilitates cross-talk within the I B kinase family during Toll-like receptor signaling

(2011) K. Clark et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bortezomib suppresses function and survival of plasmacytoid dendritic cells by targeting intracellular trafficking of Toll-like receptors and endoplasmic reticulum homeostasis

(2010) M. Hirai et al.   BLOOD

The Ubiquitin E3 Ligase RAUL Negatively Regulates Type I Interferon through Ubiquitination of the Transcription Factors IRF7 and IRF3

(2010) Yanxing Yu et al.   IMMUNITY

Negative Regulation of IRF7 Activation by Activating Transcription Factor 4 Suggests a Cross-Regulation between the IFN Responses and the Cellular Integrated Stress Responses

(2010) Q. Liang et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Critical Role of I B Kinase   in TLR7/9-Induced Type I IFN Production by Conventional Dendritic Cells

(2010) K. Hoshino et al.   JOURNAL OF IMMUNOLOGY

Dynamics within the CD95 death-inducing signaling complex decide life and death of cells

(2010) Leo Neumann et al.   Molecular Systems Biology

Functional Analysis of a Dominant Negative Mutation of Interferon Regulatory Factor 5

(2009) Long Yang et al.   PLoS One

Targeting IRFs by ubiquitination: regulating antiviral responses

(2008) Rowan Higgs et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Death Effector Domain-Containing Proteins

(2008) M. Gudur Valmiki et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

TRAF6 and the Three C-Terminal Lysine Sites on IRF7 Are Required for Its Ubiquitination-Mediated Activation by the Tumor Necrosis Factor Receptor Family Member Latent Membrane Protein 1

(2008) S. Ning et al.   MOLECULAR AND CELLULAR BIOLOGY

Translational control of the innate immune response through IRF-7

(2008) Rodney Colina et al.   NATURE

IRF7 activation by Epstein-Barr virus latent membrane protein 1 requires localization at activation sites and TRAF6, but not TRAF2 or TRAF3

(2008) Y.-J. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA