Article
Biochemistry & Molecular Biology
Xiao Lu, Alice Prodger, Jingwei Sim, Colin E. Evans
Summary: Cancer patients have a higher risk of thrombosis compared to individuals without cancer. Thrombosis can also be a diagnostic predictor of cancer, but the mechanisms by which thrombosis promotes tumor propagation are not fully understood. This study investigates the role of hypoxia-inducible factors (HIF) in myeloid cells in thrombosis-induced tumorigenesis. The results show that HIF1-alpha and HIF2-alpha levels are increased in myeloid cells of murine thrombi. Additionally, thrombosis increases HIF1-alpha and HIF2-alpha levels in murine lungs, promoting tumor development. In vitro studies also demonstrate that hypoxia upregulates tumorigenic factors in the secretome of neutrophils and macrophages, leading to lung cancer cell proliferation and migration in a myeloid-HIF-dependent manner. These findings highlight the importance of thrombotic insult and myeloid HIFs in mediating tumorigenic success.
Article
Cell Biology
Jinsheng Zhu, Li Zhao, Yadan Hu, Guoqi Cui, Ang Luo, Changlei Bao, Ying Han, Tong Zhou, Wenju Lu, Jian Wang, Stephen M. Black, Haiyang Tang
Summary: This study elucidates the importance of HIF2 alpha in the pathogenesis of pulmonary arterial hypertension, demonstrating the potential of HIF2 alpha-mediated gene sets as a diagnostic tool for distinguishing PAH patients. The study also found significant differences in the expression profiles of HIF2 alpha-mediated gene sets in lung tissues and peripheral blood mononuclear cells between control subjects and PAH patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yiwei Shi, Rui Jiang, Xiaojiang Qin, Anqi Gao, Xiaomin Hou, Liangjing Chen, Xinrong Xu, Yunting Guo, Lina Chai, Liangyuan Zhao, Xuefeng Du, Furong Wu
Summary: This study investigated the role of nPKC in mediating PASMCs proliferation in PH. The findings revealed that hypoxia promoted PASMCs proliferation, with the most significant effect observed after 72 hours of treatment. The upregulation of PKC8 and PKC? expression under hypoxia led to PASMCs proliferation via the upregulation of AKT and ERK phosphorylation. These results suggest potential novel targets for molecular therapy of pulmonary hypertension.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dan Yi, Bin Liu, Ting Wang, Qi Liao, Maggie M. Zhu, You-Yang Zhao, Zhiyu Dai
Summary: This study identified a novel mechanism of endothelial autocrine signaling in regulating PVEC proliferation and pulmonary vascular remodeling in PAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Esraa M. Zeidan, Mohammad Akbar Hossain, Mahmoud El-Daly, Mohammed A. S. Abourehab, Mohamed M. A. Khalifa, Ashraf Taye
Summary: This review summarizes the role and regulatory pathways of hypoxia-inducible factor (HIF)-related signaling in the development of pulmonary hypertension (PH), emphasizing the importance of mitochondria in HIF regulation and PH pathogenesis. The potential for therapeutically targeting the components of the HIF system for PH management is also discussed.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Emilio Y. Lucero Garcia Rojas, Cleva Villanueva, Richard A. Bond
Summary: Cardiovascular diseases are the leading cause of death in industrialized countries, with hypoxia playing a central role in their pathogenesis. The review highlights the importance of HIFs and derived factors in the development and perpetuation of hypoxia in these diseases, categorizing them into acute and chronic hypoxic states to better understand the temporal relevance of HIFs in disease progression.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Physiology
Karim Ullah, Rongxue Wu
Summary: Endothelial cells play a crucial role in maintaining cardiovascular homeostasis, tissue growth, and repair, relying on glycolysis to resist hypoxic damage and promote angiogenesis in ischemic regions. Hypoxia-inducible factors (HIFs) are key regulators of endothelial cell metabolism and angiogenesis, with varying effects on cardiovascular dysfunction in different disease settings.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Baoqi Yu, Xia Wang, Yanting Song, Guomin Xie, Shiyu Jiao, Li Shi, Xuejie Cao, Xinyao Han, Aijuan Qu
Summary: Cardiovascular diseases are the leading cause of death worldwide, and hypoxia-inducible factors (HIFs) play an important role in their pathogenesis. Recent studies have revealed the role of cell-specific HIFs in various cardiovascular diseases, but the potential clinical application of HIF inhibitors in the treatment of cardiovascular diseases is not well understood.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Pharmacology & Pharmacy
Xinguo Jiang, Wen Tian, Dongeon Kim, Alexander S. McQuiston, Ryan Vinh, Stanley G. Rockson, Gregg L. Semenza, Mark R. Nicolls
Summary: Lymphedema is a chronic inflammatory disorder with incomplete understanding of its pathology and lack of approved pharmacological therapy. Studying hypoxia-regulated pathways in lymphedema may lead to new treatment approaches.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Physiology
Cassidy Delaney, Pavel Davizon-Castillo, Ayed Allawzi, Janelle Posey, Aneta Gandjeva, Keith Neeves, Rubin M. Tuder, Jorge Di Paola, Kurt R. Stenmark, Eva S. Nozik
Summary: Platelets are increased and activated in the lungs of hypoxic mice, and their depletion prevents hypoxia-driven increases in proinflammatory chemokines CXCL4 and CCL5. The study suggests a potential contribution of platelets to inflammatory mediated vascular remodeling and pulmonary hypertension.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Junting Zhang, Yiying Li, Yujie Chen, Xiufeng Yu, Shanshan Wang, Hanliang Sun, Xiaodong Zheng, Lixin Zhang, Yifan Wang, Daling Zhu
Summary: Pulmonary hypertension (PH) is characterized by pulmonary vasoconstriction and vascular remodeling. Excessive autophagy of pulmonary artery smooth muscle cells (PASMCs) is an important factor in vascular remodeling. This study showed that hypoxia-induced circ-calm4 upregulation regulates autophagy in hypoxia-induced PASMCs. Knockdown of circ-calm4 inhibits hypoxia-induced autophagy in PASMCs. The circ-calm4/Purb/Beclin1 signal axis is involved in hypoxia-induced PASMCs autophagy.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Review
Cell Biology
Beatrice Foglia, Erica Novo, Francesca Protopapa, Marina Maggiora, Claudia Bocca, Stefania Cannito, Maurizio Parola
Summary: Liver fibrosis is a potentially reversible pathophysiological event characterized by excess deposition of extracellular matrix components, which is primarily driven by activated myofibroblasts and other hepatic cell populations involved in chronic liver disease progression. The emerging pathogenic role of hypoxia, hypoxia-inducible factors, and related mediators in the fibrogenic progression of chronic liver diseases is a key focus of research.
Article
Pharmacology & Pharmacy
Florian Dilasser, Marc Rio, Lindsay Rose, Angela Tesse, Christophe Guignabert, Gervaise Loirand, Vincent Sauzeau
Summary: This study demonstrates the protective effect of SMC Rac1 deletion against hypoxic PH. Rac1 activity in PASMCs plays a causal role in PH by promoting ROS-dependent PA remodeling and endothelial dysfunction induced by chronic hypoxia.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biology
Xiaowei Zheng, Sampath Narayanan, Cheng Xu, Sofie Eliasson Angelstig, Jacob Grunler, Allan Zhao, Alessandro Di Toro, Luciano Bernardi, Massimiliano Mazzone, Peter Carmeliet, Marianna Del Sole, Giancarlo Solaini, Elisabete A. Forsberg, Ao Zhang, Kerstin Brismar, Tomas A. Schiffer, Neda Rajamand Ekberg, Ileana Ruxandra Botusan, Fredrik Palm, Sergiu-Bogdan Catrina
Summary: Excessive production of mitochondrial reactive oxygen species (ROS) in diabetes complications is mainly caused by impaired responses to hypoxia due to the inhibition of hypoxia-inducible factor-1 (HIF-1) by hyperglycemia. Restoring HIF-1 function can attenuate ROS overproduction, protect cells against apoptosis and renal injury in diabetes. These findings suggest that targeting HIF-1 repression could be a potential therapeutic strategy for diabetic complications.
Review
Oncology
Qinghua Wu, Li You, Eugenie Nepovimova, Zbynek Heger, Wenda Wu, Kamil Kuca, Vojtech Adam
Summary: Hypoxia in the tumor microenvironment weakens cytotoxic T cell function and promotes recruitment of regulatory T cells, thereby reducing tumor immunogenicity. Hypoxia-inducible factors (HIFs), especially HIF1A and HIF2A, play important roles in tumor immune escape through various mechanisms. Understanding these mechanisms can lead to the development of targeted therapies for tumor treatment.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Xiao-lian Liu, Gui-ming Zhang, Si-si Huang, Wen-hui Shi, Lin-xuan Ye, Zhong-lu Ren, Jia-jie Zhang, Shu-wen Liu, Le Yu, Yi-lei Li
Summary: PTEN loss correlates with hypersensitivity to rapalogs in ccRCC cells and could be a marker for rapalog therapy selection in ccRCC patients.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Pharmacology & Pharmacy
Shijun He, Yuanda Wan, Liren Li, Xiaodong Tang, Wenyu Wu, Shuwen Liu, Xingang Yao
Summary: This study reveals the regulating mechanism of PKC beta inhibitor on TXNIP degradation to improve pancreatic beta-cell dysfunction.
Article
Multidisciplinary Sciences
Lei Gao, Shuwen Liu, Peter A. Cawood, Fangyang Hu, Jintuan Wang, Guozheng Sun, Yalu Hu
Summary: This study reveals the significance of redox evolution in the early Earth's mantle, as well as the relationship between chemical characteristics in basalts and crustal recycling.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Shuwen Liu, Yuanyuan Chen, Tianming Du, Wencong Zhao, Xuejing Liu, Heng Zhang, Qing Yuan, Liang Gao, Yuhui Dong, Xueyun Gao, Yong Gong, Peng Cao
Summary: In cyanobacteria and algae, flavodoxin (Fld) acts as an electron carrier during photosynthesis under stress conditions. This study presents the crystal structures of apo-Fld from Synechococcus sp. PCC 7942, revealing a potential dimer-monomer transition mechanism. The dimer serves as a standby state to stabilize itself, while the monomer is ready to bind FMN. Additionally, a docking model of the cyanobacterial Fld-FNR complex is proposed, highlighting the interactions between Fld and FNR.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Engineering, Environmental
Shuwen Liu, Qiulong Gao, Kaiming Hou, Zhangpeng Li, Jinqing Wang, Shengrong Yang
Summary: From the standpoint of fusion of solid and liquid lubrication, solvent-free MXene nanofluids were synthesized and demonstrated excellent friction-reduction and anti-wear properties even under high velocity, elevated temperature, and heavy load conditions.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Food Science & Technology
Tian Lan, Jiaqi Wang, Shihan Bao, Qinyu Zhao, Xiangyu Sun, Yulin Fang, Tingting Ma, Shuwen Liu
Summary: This review systematically examines the relationship between fruit and vegetable juice (FVJ) processing and its nutrition and function in the past 10 years, highlighting the impact of processing technology on the nutrient and functional components of FVJ, and providing new perspectives for future studies.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Computer Science, Artificial Intelligence
Yun Zhu, Chengjian Gong, Shuwen Liu, Zhiyue Yu, Hanzeng Shao, Gaohang Yu
Summary: This paper proposes a multi-channel weighted truncated WSNM model based on the WSNM optimization framework for RGB colour image denoising. The proposed model is significantly improved by the optimization methods of superposition and truncation. It is also generalized to the tensor space and employed for the infrared imaging target detection based on the spatial-temporal tensor model for the first time. The efficiency and accuracy of the algorithm are verified through extensive experiments on real infrared data.
IET IMAGE PROCESSING
(2023)
Article
Biochemistry & Molecular Biology
Simran S. Sabharwal, V. Joseph Dudley, Charlene Landwerlin, Paul T. Schumacker
Summary: Cancer cells experience increased levels of oxidant stress due to oncogene activation, nucleotide biosynthesis, and growth factor receptor signaling. Mitochondrial ROS contribute to this stress. Assessing the importance of mitochondrial ROS in cancer cells is difficult due to the effects of electron transport chain inhibitors. This study showed that mitochondrial H2O2 signaling contributes to tumor cell proliferation and survival through HIF-dependent and HIF-independent mechanisms.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Abdullah Khamis Ali Al Saidi, Adibehalsadat Ghazanfari, Shuwen Liu, Tirusew Tegafaw, Mohammad Yaseen Ahmad, Dejun Zhao, Ying Liu, So Hyeon Yang, Dong Wook Hwang, Ji-ung Yang, Ji Ae Park, Jae Chang Jung, Sung-Wook Nam, Yongmin Chang, Gang Ho Lee
Summary: Ultrasmall platinum nanoparticles (Pt-NPs) coated with three types of hydrophilic and biocompatible polymers were successfully synthesized using a one-pot polyol method. The polymer-coated Pt-NPs showed excellent stability and low cellular toxicity. They also exhibited stronger X-ray attenuation power compared to a commercial iodine contrast agent, indicating their potential as computed tomography contrast agents.
Review
Cell Biology
Haifeng Zeng, Shaoshen Guo, Xuancheng Ren, Zhenkun Wu, Shuwen Liu, Xingang Yao
Summary: Extracellular vesicles, including ectosomes and exosomes, have emerged as promising natural carriers for drug delivery. Exosomes, which are 30-100 nm in diameter and possess a lipid bilayer, have high biocompatibility, stability, and low immunogenicity, making them desirable for cargo delivery. Loading cargo into exosomes, however, remains challenging despite various strategies developed. This review provides an overview of current cargo delivery strategies using exosomes and summarizes recent approaches for loading small-molecule, nucleic acid, and protein drugs into exosomes, offering insights for more efficient drug delivery.
Article
Geography
Han Zhang, Bing-Bing Zhou, Shuwen Liu, Guohua Hu, Xing Meng, Xiaojuan Liu, Hong Shi, Yukun Gao, Haiyan Hou, Xia Li
Summary: With the patient-mobility policy and intercity transportation in China, interprovincial patient mobility has become important, but its impact on high-quality healthcare delivery is still unknown. This study analyzed the accessibility of township-level divisions to tertiary hospitals in various patient-mobility scenarios considering different transportation systems. The results showed that high-speed rail had the largest influence on high-quality healthcare utilization, while air transport was insignificant. High-speed rail can promote equitable distribution of healthcare, reducing the Gini index and urban-rural disparity in accessibility.
Article
Chemistry, Physical
Xiaonan Miao, Zhangpeng Li, Shuwen Liu, Kaiming Hou, Jinqing Wang, Shengrong Yang
Summary: This study presents a simple method to strengthen the mechanical properties and enhance the abrasion durability of MXene-based films through ionic bridging. The metal ions bridged with the surface groups of MXene and GO nanosheets to form ion-strengthened films, which significantly improved their mechanical properties and service life. The resulting MXene/GO nanocomposite films exhibit excellent lubricity and durability, making them promising lubricants in precision mechanical devices, MEMS/NEMS, etc.
APPLIED SURFACE SCIENCE
(2023)
Article
Geosciences, Multidisciplinary
Guozheng Sun, Yalu Hu, Shuwen Liu, Sanzhong Li, Jinghao Fu, Lei Gao
Summary: Diverse Neoarchean granitoid assemblages, dominated by late Neoarchean sodic diorite-TTGs (DTTGs) and sanukitoids, are prevalent in the Hengshan terrane of the North China Craton. These sanukitoids show Mg-rich chemical features and are the only high-K granitoids found in the region. The late Neoarchean DTTGs and sanukitoids were formed around 2486-2537 Ma and are characterized by high Mg# values, enriched light rare earth elements, and heterogeneous zircon Lu-Hf and whole-rock Sm-Nd isotopic components, indicating their derivation from interactions between mantle peridotite and subduction-related materials. The occurrence of late Neoarchean high-Mg magmatism in the Hengshan terrane is closely related to warm oceanic slab subduction in the active continental margin during the end of the Archean.
GEOLOGICAL SOCIETY OF AMERICA BULLETIN
(2023)
Article
Food Science & Technology
Yihe Wang, Lili Zhao, Jiaxuan Zhang, Wei An, Kan Shi, Shuwen Liu
Summary: This study successfully prepared a high cell viability starter for Oenococcus oeni fermentation by optimizing the lyoprotectant ratio and improving the processing conditions. The results showed that there was no significant difference in the malolactic fermentation (MLF) between lab-scale and pilot-scale experiments. Both O. oeni ES-1 and commercial starters completed the MLF, but ES-1 exhibited excellent aroma volatile type, concentration, and sensory score. Additionally, the fermentation capacity of O. oeni ES-1 in a pilot-scale was investigated for the first time.
ACS FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Aihua Deng, Qidi Qiu, Qinyun Sun, Zhenxiang Chen, Junyue Wang, Yu Zhang, Shuwen Liu, Tingyi Wen
Summary: In this study, a computer-aided strategy was designed to overproduce purine nucleosides based on a genome-scale metabolic network model. By blocking the degradation of purine nucleotides and enhancing the metabolic flow of the pentose phosphate pathway, the production of inosine was successfully increased.
BIOTECHNOLOGY FOR BIOFUELS AND BIOPRODUCTS
(2022)