Temporal characterization of β cell-adaptive and -maladaptive mechanisms during chronic high-fat feeding in C57BL/6NTac mice

SerpinB1 Promotes Pancreatic β Cell Proliferation

(2016) Abdelfattah El Ouaamari et al.   Cell Metabolism

IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation

(2016) Tomozumi Takatani et al.   Scientific Reports

High-fat diet-induced β-cell proliferation occurs prior to insulin resistance in C57Bl/6J male mice

(2015) Rockann E. Mosser et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Human β-Cell Proliferation and Intracellular Signaling: Part 3

(2015) Andrew F. Stewart et al.   DIABETES

Insulin demand regulates β cell number via the unfolded protein response

(2015) Rohit B. Sharma et al.   JOURNAL OF CLINICAL INVESTIGATION

Natural history of β-cell adaptation and failure in type 2 diabetes

(2015) Emilyn U. Alejandro et al.   MOLECULAR ASPECTS OF MEDICINE

β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment

(2014) Philippe A. Halban et al.   DIABETES CARE

Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity

(2014) Jacqueline F. Rivera et al.   JOURNAL OF CLINICAL INVESTIGATION

Phenylpropenoic acid glucoside augments pancreatic beta cell mass in high-fat diet-fed mice and protects beta cells from ER stress-induced apoptosis

(2014) Iris Mathijs et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Peroxisome proliferator-activated receptor gamma (PPARG) modulates free fatty acid receptor 1 (FFAR1) dependent insulin secretion in humans

(2014) Robert Wagner et al.   Molecular Metabolism

Adaptive β-cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression

(2013) Rachel E. Stamateris et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Islet β cell mass in diabetes and how it relates to function, birth, and death

(2013) Gordon C. Weir et al.   Annals of the New York Academy of Sciences

Lost in translation: endoplasmic reticulum stress and the decline ofβ-cell health in diabetes mellitus

(2013) C. Evans-Molina et al.   DIABETES OBESITY & METABOLISM

Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding

(2013) M. K. Montgomery et al.   DIABETOLOGIA

Insulin Hypersecretion in Islets From Diet-Induced Hyperinsulinemic Obese Female Mice Is Associated With Several Functional Adaptations in Individual β-Cells

(2013) Alejandro Gonzalez et al.   ENDOCRINOLOGY

Calreticulin novel mutations in type 2 diabetes mellitus

(2013) Sanaz Mahmazi et al.   International Journal of Diabetes in Developing Countries

Peroxisome Proliferator-activated Receptor γ (PPARγ) and Its Target Genes Are Downstream Effectors of FoxO1 Protein in Islet β-Cells

(2013) Dhananjay Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future

(2013) Steven E Kahn et al.   LANCET

PPAR-γ Activation Increases Insulin Secretion through the Up-regulation of the Free Fatty Acid Receptor GPR40 in Pancreatic β-Cells

(2013) Hyo-Sup Kim et al.   PLoS One

Endoplasmic Reticulum Stress, Pancreatic  -Cell Degeneration, and Diabetes

(2013) F. R. Papa   Cold Spring Harbor Perspectives in Medicine

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

 -Cell Mass and Turnover in Humans: Effects of obesity and aging

(2012) Y. Saisho et al.   DIABETES CARE

Simultaneous Measurement of Insulin Sensitivity, Insulin Secretion, and the Disposition Index in Conscious Unhandled Mice

(2012) Laura C. Alonso et al.   Obesity

Control of Pancreatic β Cell Regeneration by Glucose Metabolism

(2011) Shay Porat et al.   Cell Metabolism

Obesity is associated with hypothalamic injury in rodents and humans

(2011) Joshua P. Thaler et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased β-cell volume in mice fed a high-fat diet: A dynamic study over 12 months

(2011) Jonatan Ahrén et al.   Islets

Physiologic and Pharmacologic Modulation of Glucose-Dependent Insulinotropic Polypeptide (GIP) Receptor Expression in  -Cells by Peroxisome Proliferator-Activated Receptor (PPAR)-  Signaling: Possible Mechanism for the GIP Resistance in Type 2 Diabetes

(2010) D. Gupta et al.   DIABETES

 -Cell Failure in Diet-Induced Obese Mice Stratified According to Body Weight Gain: Secretory Dysfunction and Altered Islet Lipid Metabolism Without Steatosis or Reduced  -Cell Mass

(2010) M.-L. Peyot et al.   DIABETES

 -Cell Growth and Regeneration: Replication Is Only Part of the Story

(2010) S. Bonner-Weir et al.   DIABETES

The hypoxia response pathway and β-cell function

(2010) J. Cantley et al.   DIABETES OBESITY & METABOLISM

Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy

(2010) A. E. Butler et al.   DIABETOLOGIA

Regulation of insulin secretion: role of mitochondrial signalling

(2010) S. Jitrapakdee et al.   DIABETOLOGIA

Peroxisome Proliferator-Activated Receptor   Activation Restores Islet Function in Diabetic Mice through Reduction of Endoplasmic Reticulum Stress and Maintenance of Euchromatin Structure

(2009) C. Evans-Molina et al.   MOLECULAR AND CELLULAR BIOLOGY

Characterization of β-Cell Mass and Insulin Resistance in Diet-induced Obese and Diet-resistant Rats

(2009) Sarah J. Paulsen et al.   Obesity

Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress

(2009) Mira M. Sachdeva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced β-cell mass without increased proliferation following chronic mild glucose infusion

(2008) Thomas L. Jetton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Calreticulin regulates insulin receptor expression and its downstream PI3 Kinase/Akt signalling pathway

(2008) Shahrzad Jalali et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A Role for von Hippel-Lindau Protein in Pancreatic  -Cell Function

(2008) S. Puri et al.   DIABETES

The Unfolded Protein Response: A Pathway That Links Insulin Demand with β-Cell Failure and Diabetes

(2008) Donalyn Scheuner et al.   ENDOCRINE REVIEWS

In Vivoandin VitroStudies of a Functional Peroxisome Proliferator-activated Receptor γ Response Element in the Mousepdx-1Promoter

(2008) Dhananjay Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes

(2008) Benbo Song et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of Pancreatic   Cell Mass by Neuronal Signals from the Liver

(2008) J. Imai et al.   SCIENCE