The RNA-binding protein Tristetraprolin (TTP) is a critical negative regulator of the NLRP3 inflammasome

Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression

(2016) E A Ross et al.   ANNALS OF THE RHEUMATIC DISEASES

The control of inflammation via the phosphorylation and dephosphorylation of tristetraprolin: a tale of two phosphatases

(2016) Andrew R. Clark et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Post-translational regulation of inflammasomes

(2016) Jie Yang et al.   Cellular & Molecular Immunology

Interleukin 1β Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency

(2016) Dror S. Shouval et al.   GASTROENTEROLOGY

Tristetraprolin binding site atlas in the macrophage transcriptome reveals a switch for inflammation resolution

(2016) Vitaly Sedlyarov et al.   Molecular Systems Biology

The RNA-binding protein TTP is a global post-transcriptional regulator of feedback control in inflammation

(2016) Christopher Tiedje et al.   NUCLEIC ACIDS RESEARCH

Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies

(2016) Sonika Patial et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Inflammasomes and Autoinflammatory Syndromes

(2015) Lori Broderick et al.   Annual Review of Pathology-Mechanisms of Disease

UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis

(2015) Jong-Seok Moon et al.   JOURNAL OF CLINICAL INVESTIGATION

Tr1 Cells, but Not Foxp3+Regulatory T Cells, Suppress NLRP3 Inflammasome Activation via an IL-10–Dependent Mechanism

(2015) Yu Yao et al.   JOURNAL OF IMMUNOLOGY

Tristetraprolin Recruits Eukaryotic Initiation Factor 4E2 To Repress Translation of AU-Rich Element-Containing mRNAs

(2015) Xianzun Tao et al.   MOLECULAR AND CELLULAR BIOLOGY

Posttranscriptional control of NLRP3 inflammasome activation in colonic macrophages

(2015) A A Filardy et al.   Mucosal Immunology

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Alternative 3′ UTRs act as scaffolds to regulate membrane protein localization

(2015) Binyamin D. Berkovits et al.   NATURE

Spontaneous retrotransposon insertion intoTNF3′UTR causes heart valve disease and chronic polyarthritis

(2015) Derek Lacey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mRNA 3′-UTR shortening is a molecular signature of mTORC1 activation

(2015) Jae-Woong Chang et al.   Nature Communications

Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation

(2015) Prajwal Gurung et al.   Scientific Reports

Inflammasome activation has an important role in the development of spontaneous colitis

(2014) J Zhang et al.   Mucosal Immunology

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

(2014) Lieselotte Vande Walle et al.   NATURE

Tristetraprolin Mediates Anti-Inflammatory Effect of Carbon Monoxide against DSS-Induced Colitis

(2014) Yeonsoo Joe et al.   PLoS One

Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction

(2014) Claire J Greenhill et al.   ARTHRITIS RESEARCH & THERAPY

Tristetraprolin (TTP): Interactions with mRNA and proteins, and current thoughts on mechanisms of action

(2013) Seth A. Brooks et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Ubiquitously transcribed genes use alternative polyadenylation to achieve tissue-specific expression

(2013) S. Lianoglou et al.   GENES & DEVELOPMENT

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Tristetraprolin regulation of interleukin 23 mRNA stability prevents a spontaneous inflammatory disease

(2013) Céline Molle et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

Protective and Aggravating Effects of Nlrp3 Inflammasome Activation in IBD Models: Influence of Genetic and Environmental Factors

(2012) Christian Bauer et al.   DIGESTIVE DISEASES

Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation

(2012) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: IL-10-Mediated Tristetraprolin Induction Is Part of a Feedback Loop That Controls Macrophage STAT3 Activation and Cytokine Production

(2012) A. Gaba et al.   JOURNAL OF IMMUNOLOGY

NLRP3 Inflammasome Activity Is Negatively Controlled by miR-223

(2012) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: miR-223 and EBV miR-BART15 Regulate the NLRP3 Inflammasome and IL-1  Production

(2012) M. Haneklaus et al.   JOURNAL OF IMMUNOLOGY

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Genome-Wide Assessment of AU-Rich Elements by the AREScore Algorithm

(2012) Milan Spasic et al.   PLoS Genetics

E2F mediates enhanced alternative polyadenylation in proliferation

(2012) Ran Elkon et al.   GENOME BIOLOGY

Deletion of Tristetraprolin Caused Spontaneous Reactive Granulopoiesis by a Non-Cell-Autonomous Mechanism Without Disturbing Long-Term Hematopoietic Stem Cell Quiescence

(2011) I. M. Kaplan et al.   JOURNAL OF IMMUNOLOGY

Zinc Finger Protein Tristetraprolin Interacts with CCL3 mRNA and Regulates Tissue Inflammation

(2011) J.-G. Kang et al.   JOURNAL OF IMMUNOLOGY

AU-Rich-Element-Dependent Translation Repression Requires the Cooperation of Tristetraprolin and RCK/P54

(2011) M.-Y. Qi et al.   MOLECULAR AND CELLULAR BIOLOGY

NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy

(2011) C. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

(2010) C. Bauer et al.   GUT

The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis

(2010) Md. Hasan Zaki et al.   IMMUNITY

MAPKAP Kinase 2 Blocks Tristetraprolin-directed mRNA Decay by Inhibiting CAF1 Deadenylase Recruitment

(2010) Francesco P. Marchese et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

(2010) Irving C. Allen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense againstSalmonella

(2010) Petr Broz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tripartite-Motif Protein 30 Negatively Regulates NLRP3 Inflammasome Activation by Modulating Reactive Oxygen Species Production

(2010) Y. Hu et al.   JOURNAL OF IMMUNOLOGY

Phosphorylation of Tristetraprolin by MK2 Impairs AU-Rich Element mRNA Decay by Preventing Deadenylase Recruitment

(2010) S. L. Clement et al.   MOLECULAR AND CELLULAR BIOLOGY

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Widespread Shortening of 3′UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells

(2009) Christine Mayr et al.   CELL

Tristetraprolin Is Required for Full Anti-Inflammatory Response of Murine Macrophages to IL-10

(2009) B. Schaljo et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: TNF-  Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation

(2009) L. Franchi et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Regulation of Tristetraprolin Expression by Interleukin-1  and Dexamethasone in Human Pulmonary Epithelial Cells: Roles for Nuclear Factor- B and p38 Mitogen-Activated Protein Kinase

(2009) E. M. King et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Proliferating Cells Express mRNAs with Shortened 3' Untranslated Regions and Fewer MicroRNA Target Sites

(2008) R. Sandberg et al.   SCIENCE