Article
Multidisciplinary Sciences
Jeremy Di Domizio, Muhammet F. Gulen, Fanny Saidoune, Vivek V. Thacker, Ahmad Yatim, Kunal Sharma, Theo Nass, Emmanuella Guenova, Martin Schaller, Curdin Conrad, Christine Goepfert, Laurence de Leval, Christophe von Garnier, Sabina Berezowska, Anaelle Dubois, Michel Gilliet, Andrea Ablasser
Summary: This study reveals the mechanism behind aberrant type I interferon responses in COVID-19 through the cGAS-STING pathway and demonstrates its importance in severe cases. By using animal and lung-on-chip models, the study provides insights into host-directed therapeutic strategies for COVID-19.
Article
Virology
Lei Chen, Xiangrong Li, Yingying Deng, Yingjie Bi, Zhenfang Yan, Yanmei Yang, Xiangbo Zhang, Huixia Li, Jingying Xie, Ruofei Feng
Summary: In this study, it was found that IFITM proteins can significantly inhibit EMCV infectivity and promote IFN-beta production by facilitating MDA5 expression. The N-terminal domain of IFITM2 plays an active role in antiviral activity and IFN-beta activation. These findings highlight the vital role of IFITM2 in antiviral signaling and its positive feed-forward loop with type I IFN.
Article
Virology
Daniel D. T. Andrews, Marli Vlok, Dorssa Akbari Bani, Brenna N. Hay, Yasir Mohamud, Leonard J. Foster, Honglin Luo, Christopher M. Overall, Eric Jan
Summary: Host antiviral factors use the retinoic acid-inducible gene I (RIG-I)-like receptor pathway to sense virus infection and trigger the production of interferons, which establish an antiviral state. The chaperone protein 14-3-3 & epsilon; plays a key role in this pathway by facilitating the delivery of the viral sensor protein RIG-I to the mitochondria. However, the enteroviral 3C protease cleaves 14-3-3 & epsilon; during infection, disrupting its function and promoting virus infection. This study reveals a novel viral strategy that evades the host antiviral response.
JOURNAL OF VIROLOGY
(2023)
Article
Immunology
Simon Loevenich, Alix S. Spahn, Kristin Rian, Victor Boyartchuk, Marit Walbye Anthonsen
Summary: Viral infection induces the regulation of IRF1 expression through TBK1 and IFN-β via the NF-κB signaling pathway, and in later stages of infection, it heavily relies on IFN-β-mediated signaling through the IFNAR-STAT1 pathway. This mechanism's discovery is relevant not only to defense against HMPV, but also to other viral, bacterial, and fungal pathogens.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Lance N. Benson, Yunmeng Liu, Xiangting Wang, Yunzhao Xiong, Sung W. Rhee, Yunping Guo, Katherine S. Deck, Christoph J. Mora, Lin-Xi Li, Lu Huang, J. Tucker Andrews, Zhiqiang Qin, Robert S. Hoover, Benjamin Ko, Ryan M. Williams, Daniel A. Heller, Edgar A. Jaimes, Shengyu Mu
Summary: This study investigated the interaction between CD8T cells and DCTs and its impact on hypertension. The results showed that activated CD8T cells enhance the interaction with DCTs through the upregulation of MHC-I and PDL1 on DCTs via IFN-gamma, leading to increased NCC expression in DCTs, excessive salt retention, and persistent elevation of blood pressure. Eliminating IFN-gamma or specific knockdown of PDL1 on DCTs prevented T cell homing into the kidney, thereby attenuating hypertension.
CIRCULATION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Ioannis Kienes, Tanja Weidl, Nora Mirza, Mathias Chamaillard, Thomas A. Kufer
Summary: Type I interferon signaling is crucial for immune responses to viruses, fungi, or bacteria, but the amplitude and timing of the response are also key to preventing inadequate outcomes or tissue damage. NLRs, a family of proteins capable of sensing microbial products and signals related to tissue injury, regulate the quality of interferon signaling. Current understanding of the function of NLRs in type I interferon responses is incomplete, but they play important roles in influencing the immune response to viral infections and the development of autoimmunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Bo-Ram Jo, Hyun-Soo Kim, Jeong-Won Ahn, Eui-Young Jeoung, Su-Kil Jang, Yeong-Min Yoo, Seong-Soo Joo
Summary: Pathogenesis-related (PR) proteins in plants play a crucial role in plant defense against microbial attacks. In this study, a novel PR-1-like protein (OPRP) was identified and its pharmacologic relevance and cell signaling in mammalian cells were examined. The purified full-length OPRP protein increased the expression levels of genes involved in the immune response, while small peptides designed from OPRP upregulated antiviral genes in mouse splenocytes and human epithelial cells. OPRP and its small peptides activated specific signaling pathways and inhibited viral entry into host cells.
Article
Gastroenterology & Hepatology
Ghaffar Muharram, Marion Thepaut, Pierre-Emmanuel Lobert, Teddy Grandjean, Olivier Boulard, Myriam Delacre, Emmrich Wakeford, Richard Wheeler, Lionel Franz Poulin, Ivo Gomperts Boneca, Frank Lafont, Marie-Cecile Michallet, Didier Hober, Ken Cadwell, Mathias Chamaillard
Summary: More than 90% of non-bacterial gastroenteritis is caused by human noroviruses (NoVs), which persist in some individuals and lead to significant outbreaks and high mortality in developing countries. NoVs primarily transmit through the fecal-oral route. This study reveals the exacerbation of colitis severity caused by norovirus is dependent on bacterial sensing by Nod2.
Article
Immunology
Zixuan Wang, Jing Xu, Jianhua Feng, Kaizheng Wu, Kangyong Chen, Zhao Jia, Xiaozhen Zhu, Wenji Huang, Xin Zhao, Qin Liu, Bangjie Wang, Xinhua Chen, Junya Wang, Jun Zou
Summary: This study reveals the interaction mechanism between fish type I interferons and receptors by solving the crystal structure of grass carp IFNa. The results show that fish type I interferons may interact with receptors in a different way compared to their mammalian homologs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Misa Nakasuji-Togi, Sumihito Togi, Keita Saeki, Yasuhiko Kojima, Keiko Ozato
Summary: The study found that the internatural (INT) mixture can induce type I interferons (IFNs) in murine bone marrow-derived macrophages (BMDMs) to enhance the body's immunity. This induction is mediated by the Toll-like receptor 4 (TLR4) pathway. The supernatants from INT-treated cells also displayed antiviral activity.
FOOD & NUTRITION RESEARCH
(2022)
Article
Oncology
Mirco Friedrich, Roman Sankowski, Lukas Bunse, Michael Kilian, Edward Green, Carina Ramallo Guevara, Stefan Pusch, Gernot Poschet, Khwab Sanghvi, Markus Hahn, Theresa Bunse, Philipp Muench, Hagen M. Gegner, Jana K. Sonner, Anna von Landenberg, Frederik Cichon, Katrin Aslan, Tim Trobisch, Lucas Schirmer, Denis Abu-Sammour, Tobias Kessler, Miriam Ratliff, Daniel Schrimpf, Felix Sahm, Carsten Hopf, Dieter H. Heiland, Oliver Schnell, Jurgen Beck, Chotima Boettcher, Camila Fernandez-Zapata, Josef Priller, Sabine Heiland, Ilona Gutcher, Francisco J. Quintana, Andreas von Deimling, Wolfgang Wick, Marco Prinz, Michael Platten
Summary: The study identifies different states of myeloid cells in gliomas and demonstrates that IDH-mutant tumors re-educate infiltrating macrophages through tryptophan metabolism, resulting in the formation of an immunosuppressive microenvironment. This suggests that targeting tryptophan metabolism could be a potential immunotherapy strategy for IDH-mutant tumors.
Review
Biochemistry & Molecular Biology
Ashley A. Stegelmeier, Maedeh Darzianiazizi, Kiersten Hanada, Shayan Sharif, Sarah K. Wootton, Byram W. Bridle, Khalil Karimi
Summary: Interferons play a crucial role in regulating host antiviral response, while neutrophils contribute to antiviral defense as host cells. The complex cross-regulatory talk between interferons and neutrophils is essential for initiating appropriate antiviral immune responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Jialu Zhang, Yaohong Zhu, Xiaojia Wang, Jiufeng Wang
Summary: Cholesterol and its metabolite 25HC play crucial roles in viral entry and replication, as well as serving as regulators of innate immune response. In addition to interferon regulation, 25HC modulates cholesterol metabolism, autophagy, and inflammation through signaling pathways.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Yongzhi Chen, Xuqiu Lei, Zhaozhao Jiang, Katherine A. Fitzgerald
Summary: CNBP plays a crucial role in the production of type I interferons in response to RNA virus infection. It controls the recruitment of IRF3 and IRF7 to IFN promoters and directly binds to the promoter of IFNb in the nucleus. This provides an additional layer of control for the antiviral innate immune response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Cell Biology
Mohamad Mahjoor, Golnaz Mahmoudvand, Simin Farokhi, Alireza Shadab, Mojtaba Kashfi, Hamed Afkhami
Summary: The JAK/STAT signaling cascade plays a crucial role in regulating cell growth and differentiation, as well as immune responses and viral pathogenesis.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Cell Biology
Wu-Chang Zhang, Xiao-Jun Zheng, Lin-Juan Du, Jian-Yong Sun, Zhu-Xia Shen, Chaoji Shi, Shuyang Sun, Zhiyuan Zhang, Xiao-qing Chen, Mu Qin, Xu Liu, Jun Tao, Lijun Jia, Heng-yu Fan, Bin Zhou, Ying Yu, Hao Ying, Lijian Hui, Xiaolong Liu, Xianghua Yi, Xiaojing Liu, Lanjing Zhang, Sheng-Zhong Duan
Article
Biology
Xiaoqing Chen, Wuchang Zhang, Qian Wang, Lili Du, Yi Yi, Yan Liu, Xu Liu, Shengzhong Duan
SCIENCE CHINA-LIFE SCIENCES
(2016)
Article
Oncology
Xiao-Jun Zheng, Yuan Liu, Wu-Chang Zhang, Yan Liu, Chao Li, Xue-Nan Sun, Yu-Yao Zhang, Jie Xu, Xinquan Jiang, Lanjing Zhang, Wei Yang, Sheng-Zhong Duan
JOURNAL OF PATHOLOGY
(2019)
Article
Cell Biology
Juanjuan Yuan, Ting Cai, Xiaojun Zheng, Yangzi Ren, Jingwen Qi, Xiaofei Lu, Huihui Chen, Huizhen Lin, Zijie Chen, Mengnan Liu, Shangwen He, Qijun Chen, Siyang Feng, Yingjun Wu, Wei Yang, Yanqing Ding, Zhenhai Zhang
Summary: The study reveals the crucial role of LDLR in regulating the antitumor activity of CD8(+) T cells, including promoting T cell priming and clonal expansion, as well as regulating TCR signaling through interaction with the TCR complex. Moreover, the tumor microenvironment suppresses LDLR and TCR signaling in CD8(+) T cells via PCSK9, inhibiting the effector function of CTLs.
Correction
Cell Biology
Juanjuan Yuan, Ting Cai, Xiaojun Zheng, Yangzi Ren, Jingwen Qi, Xiaofei Lu, Huihui Chen, Huizhen Lin, Zijie Chen, Mengnan Liu, Shangwen He, Qijun Chen, Siyang Feng, Yingjun Wu, Zhenhai Zhang, Yanqing Ding, Wei Yang
Summary: A correction to this paper has been published.