Fructose and glucose can regulate mammalian target of rapamycin complex 1 and lipogenic gene expression via distinct pathways

Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production

(2016) Paul M. Titchenell et al.   Cell Metabolism

ChREBP regulates fructose-induced glucose production independently of insulin signaling

(2016) Mi-Sung Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Fructose, but not glucose, impairs insulin signaling in the three major insulin-sensitive tissues

(2016) Miguel Baena et al.   Scientific Reports

Fructose supplementation impairs rat liver autophagy through mTORC activation without inducing endoplasmic reticulum stress

(2015) Miguel Baena et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Restoration of Autophagy Alleviates Hepatic ER Stress and Impaired Insulin Signalling Transduction in High Fructose-Fed Male Mice

(2015) Hao Wang et al.   ENDOCRINOLOGY

Insulin Is Required to Maintain Albumin Expression by Inhibiting Forkhead Box O1 Protein

(2015) Qing Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis

(2015) Ji Miao et al.   Nature Communications

Fructose leads to hepatic steatosis in zebrafish that is reversed by mechanistic target of rapamycin (mTOR) inhibition

(2014) Valerie Sapp et al.   HEPATOLOGY

Prevalence of Childhood and Adult Obesity in the United States, 2011-2012

(2014) Cynthia L. Ogden et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Hepatic nuclear corepressor 1 regulates cholesterol absorption through a TRβ1-governed pathway

(2014) Inna Astapova et al.   JOURNAL OF CLINICAL INVESTIGATION

Misconceptions about fructose-containing sugars and their role in the obesity epidemic

(2014) Vincent J. van Buul et al.   NUTRITION RESEARCH REVIEWS

Liver X Receptor Regulates Arachidonic Acid Distribution and Eicosanoid Release in Human Macrophages

(2013) Minako Ishibashi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Sugar, Uric Acid, and the Etiology of Diabetes and Obesity

(2013) R. J. Johnson et al.   DIABETES

Hepatic Insulin Signaling Is Required for Obesity-Dependent Expression of SREBP-1c mRNA but Not for Feeding-Dependent Expression

(2012) Joel T. Haas et al.   Cell Metabolism

A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism

(2012) Mark A. Herman et al.   NATURE

Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

(2012) Han Cho et al.   NATURE

Public health: The toxic truth about sugar

(2012) Robert H. Lustig et al.   NATURE

Functional roles of fructose

(2012) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional Control of Cellular Metabolism by mTOR Signaling

(2011) J. L. Yecies et al.   CANCER RESEARCH

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

(2011) Timothy R. Peterson et al.   CELL

Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

(2011) Jessica L. Yecies et al.   Cell Metabolism

Dietary Phospholipids Ameliorate Fructose-Induced Hepatic Lipid and Metabolic Abnormalities in Rats

(2011) Takuya Mori et al.   JOURNAL OF NUTRITION

Transcriptional profiling reveals a role for RORα in regulating gene expression in obesity-associated inflammation and hepatic steatosis

(2011) Hong Soon Kang et al.   PHYSIOLOGICAL GENOMICS

A Circadian Rhythm Orchestrated by Histone Deacetylase 3 Controls Hepatic Lipid Metabolism

(2011) D. Feng et al.   SCIENCE

Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

(2011) Y. Yu et al.   SCIENCE

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

(2011) P. P. Hsu et al.   SCIENCE

Adiponectin protects against doxorubicin-induced cardiomyopathy by anti-apoptotic effects through AMPK up-regulation

(2010) Masanori Konishi et al.   CARDIOVASCULAR RESEARCH

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

(2010) Shomit Sengupta et al.   NATURE

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

(2010) Shijie Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prevalence and correlates of metabolic syndrome based on a harmonious definition among adults in the US*

(2010) Earl S. FORD et al.   Journal of Diabetes

The Role of Peroxisome Proliferator-Activated Receptor γ Coactivator-1 β in the Pathogenesis of Fructose-Induced Insulin Resistance

(2009) Yoshio Nagai et al.   Cell Metabolism

Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans

(2009) Kimber L. Stanhope et al.   JOURNAL OF CLINICAL INVESTIGATION

Glycolytic Flux Signals to mTOR through Glyceraldehyde-3-Phosphate Dehydrogenase-Mediated Regulation of Rheb

(2009) M. N. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

(2008) Thomas Porstmann et al.   Cell Metabolism

ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver

(2008) Pierre-Damien Denechaud et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential effects of central fructose and glucose on hypothalamic malonyl-CoA and food intake

(2008) S. H. Cha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo

(2008) I. Astapova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA