The SecA protein deeply penetrates into the SecYEG channel during insertion, contacting most channel transmembrane helices and periplasmic regions

Determination of the Oligomeric State of SecYEG Protein Secretion Channel Complex Usingin VivoPhoto- and Disulfide Cross-linking

(2016) Zeliang Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SecA functions in vivo as a discrete anti-parallel dimer to promote protein transport

(2016) Tithi Banerjee et al.   MOLECULAR MICROBIOLOGY

Crystal structure of a substrate-engaged SecY protein-translocation channel

(2016) Long Li et al.   NATURE

Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation

(2016) William John Allen et al.   eLife

Crystal Structures of SecYEG in Lipidic Cubic Phase Elucidate a Precise Resting and a Peptide-Bound State

(2015) Yoshiki Tanaka et al.   Cell Reports

A “Push and Slide” Mechanism Allows Sequence-Insensitive Translocation of Secretory Proteins by the SecA ATPase

(2014) Benedikt W. Bauer et al.   CELL

Reconstitution of functionally efficient SecA-dependent protein-conducting channels: Transformation of low-affinity SecA-liposome channels to high-affinity SecA-SecYEG-SecDF·YajC channels

(2013) Ying-hsin Hsieh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

YidC Occupies the Lateral Gate of the SecYEG Translocon and Is Sequentially Displaced by a Nascent Membrane Protein

(2013) Ilie Sachelaru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of Sec61/SecY-Mediated Protein Translocation Across Membranes

(2012) Eunyong Park et al.   Annual Review of Biophysics

Mobility of the SecA 2-helix-finger is not essential for polypeptide translocation via the SecYEG complex

(2012) Sarah Whitehouse et al.   JOURNAL OF CELL BIOLOGY

Bacterial protein translocation requires only one copy of the SecY complex in vivo

(2012) Eunyong Park et al.   JOURNAL OF CELL BIOLOGY

The bacterial Sec-translocase: structure and mechanism

(2012) J. A. Lycklama a Nijeholt et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

SecA Alone Can Promote Protein Translocation and Ion Channel Activity

(2011) Ying-hsin Hsieh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mapping of the SecA·SecY and SecA·SecG Interfaces by Site-directedin VivoPhotocross-linking

(2011) Sanchaita Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and function of a membrane component SecDF that enhances protein export

(2011) Tomoya Tsukazaki et al.   NATURE

Probing the SecYEG translocation pore size with preproteins conjugated with sizable rigid spherical molecules

(2011) F. Bonardi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quaternary Structure of SecA in Solution and Bound to SecYEG Probed at the Single Molecule Level

(2011) Ilja Kusters et al.   STRUCTURE

The Sec translocase

(2010) David J.F. du Plessis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes

(2010) P. F. Egea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A role for the two-helix finger of the SecA ATPase in protein translocation

(2008) Karl J. Erlandson et al.   NATURE

Structure of a complex of the ATPase SecA and the protein-translocation channel

(2008) Jochen Zimmer et al.   NATURE

Conformational transition of Sec machinery inferred from bacterial SecYE structures

(2008) Tomoya Tsukazaki et al.   NATURE