The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome

Ubiquitin ligase E6AP mediates nonproteolytic polyubiquitylation of β-catenin independent of the E6 oncoprotein

(2016) Yael Kuslansky et al.   JOURNAL OF GENERAL VIROLOGY

An atomic structure of the human 26S proteasome

(2016) Xiuliang Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Neocortical neurogenesis and the etiology of autism spectrum disorder

(2016) Alan Packer   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds

(2016) Babita Madan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proliferation and Differentiation Deficits are a Major Convergence Point for Neurodevelopmental Disorders

(2016) Carl Ernst   TRENDS IN NEUROSCIENCES

An atomic structure of the human 26S proteasome

(2016) Xiuliang Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An Autism-Linked Mutation Disables Phosphorylation Control of UBE3A

(2015) Jason J. Yi et al.   CELL

A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances

(2015) Marco Y. Hein et al.   CELL

15q11.2 Duplication Encompassing Only theUBE3AGene Is Associated with Developmental Delay and Neuropsychiatric Phenotypes

(2015) Abdul Noor et al.   HUMAN MUTATION

FOXP1 potentiates Wnt/β-catenin signaling in diffuse large B cell lymphoma

(2015) Matthew P. Walker et al.   Science Signaling

Angelman syndrome-associated ubiquitin ligase UBE3A/E6AP mutants interfere with the proteolytic activity of the proteasome

(2015) V Tomaić et al.   Cell Death & Disease

Epigenetic regulation of UBE3A and roles in human neurodevelopmental disorders

(2015) Janine M LaSalle et al.   Epigenomics

Wnt Signaling Translocates Lys48-Linked Polyubiquitinated Proteins to the Lysosomal Pathway

(2015) Hyunjoon Kim et al.   Cell Reports

FOXP1 potentiates Wnt/β-catenin signaling in diffuse large B cell lymphoma

(2015) Matthew P. Walker et al.   Science Signaling

From UBE3A to Angelman syndrome: a substrate perspective

(2015) Gabrielle L. Sell et al.   Frontiers in Neuroscience

Autoubiquitination of the 26S Proteasome on Rpn13 Regulates Breakdown of Ubiquitin Conjugates

(2014) H. C. Besche et al.   EMBO JOURNAL

Wnt some lose some: transcriptional governance of stem cells by Wnt/ -catenin signaling

(2014) W.-H. Lien et al.   GENES & DEVELOPMENT

Dominant β-catenin mutations cause intellectual disability with recognizable syndromic features

(2014) Valter Tucci et al.   JOURNAL OF CLINICAL INVESTIGATION

Autoregulation of the 26S proteasome by in situ ubiquitination

(2014) Andrew D. Jacobson et al.   MOLECULAR BIOLOGY OF THE CELL

Synaptic, transcriptional and chromatin genes disrupted in autism

(2014) Silvia De Rubeis et al.   NATURE

The contribution of de novo coding mutations to autism spectrum disorder

(2014) Ivan Iossifov et al.   NATURE

Triad3A Regulates Synaptic Strength by Ubiquitination of Arc

(2014) Angela M. Mabb et al.   NEURON

A de novo convergence of autism genetics and molecular neuroscience

(2014) Niklas Krumm et al.   TRENDS IN NEUROSCIENCES

HPV16 E6 and E6AP differentially cooperate to stimulate or augment Wnt signaling

(2014) Sophia Sominsky et al.   VIROLOGY

The Interstitial Duplication 15q11.2-q13 Syndrome Includes Autism, Mild Facial Anomalies and a Characteristic EEG Signature

(2013) Nora Urraca et al.   Autism Research

Ube3a, the E3 ubiquitin ligase causing Angelman syndrome and linked to autism, regulates protein homeostasis through the proteasomal shuttle Rpn10

(2013) So Young Lee et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Prenatal Valproate Exposure and Risk of Autism Spectrum Disorders and Childhood Autism

(2013) Jakob Christensen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Allelic specificity of Ube3a Expression In The Mouse Brain During Postnatal Development

(2013) Matthew C. Judson et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Role of the ubiquitin ligase E6AP/UBE3A in controlling levels of the synaptic protein Arc

(2013) S. Kuhnle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt Stabilization of  -Catenin Reveals Principles for Morphogen Receptor-Scaffold Assemblies

(2013) S.-E. Kim et al.   SCIENCE

The Ubiquitin Receptor S5a/Rpn10 Links Centrosomal Proteasomes with Dendrite Development in the Mammalian Brain

(2013) Sidharth V. Puram et al.   Cell Reports

Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex

(2012) Vivian S.W. Li et al.   CELL

A Census of Human Soluble Protein Complexes

(2012) Pierre C. Havugimana et al.   CELL

Identification and Proteomic Analysis of Distinct UBE3A/E6AP Protein Complexes

(2012) G. Martinez-Noel et al.   MOLECULAR AND CELLULAR BIOLOGY

Maternal Loss of Ube3a Produces an Excitatory/Inhibitory Imbalance through Neuron Type-Specific Synaptic Defects

(2012) Michael L. Wallace et al.   NEURON

Wnt Signaling in Cancer

(2012) P. Polakis   Cold Spring Harbor Perspectives in Biology

A sensitive and bright single-cell resolution live imaging reporter of Wnt/ß-catenin signaling in the mouse

(2011) Anna Ferrer-Vaquer et al.   BMC DEVELOPMENTAL BIOLOGY

Maintaining embryonic stem cell pluripotency with Wnt signaling

(2011) S. Y. Sokol   DEVELOPMENT

Angelman syndrome: insights into genomic imprinting and neurodevelopmental phenotypes

(2011) Angela M. Mabb et al.   TRENDS IN NEUROSCIENCES

EphB-Mediated Degradation of the RhoA GEF Ephexin5 Relieves a Developmental Brake on Excitatory Synapse Formation

(2010) Seth S. Margolis et al.   CELL

Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling

(2010) Guoqiang Xu et al.   NATURE BIOTECHNOLOGY

A human MAP kinase interactome

(2010) Sourav Bandyopadhyay et al.   NATURE METHODS

Beta-Catenin Signaling Negatively Regulates Intermediate Progenitor Population Numbers in the Developing Cortex

(2010) Christopher A. Mutch et al.   PLoS One

Regulators of the Proteasome Pathway, Uch37 and Rpn13, Play Distinct Roles in Mouse Development

(2010) Amin Al-Shami et al.   PLoS One

Regulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome

(2010) D. Zaaroor-Regev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of the brain 26S proteasome and its interacting proteins

(2010) Hwan-Ching Tai   Frontiers in Molecular Neuroscience

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

The Ubiquitin Ligase E6-AP Is Induced and Recruited to Aggresomes in Response to Proteasome Inhibition and May Be Involved in the Ubiquitination of Hsp70-bound Misfolded Proteins

(2009) Amit Mishra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ubiquitin-interacting Motif Protein, S5a, Is Ubiquitinated by All Types of Ubiquitin Ligases by a Mechanism Different from Typical Substrate Recognition

(2009) Tomoaki Uchiki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autism genome-wide copy number variation reveals ubiquitin and neuronal genes

(2009) Joseph T. Glessner et al.   NATURE

Ube3a is required for experience-dependent maturation of the neocortex

(2009) Koji Yashiro et al.   NATURE NEUROSCIENCE

GSK-3 is a master regulator of neural progenitor homeostasis

(2009) Woo-Yang Kim et al.   NATURE NEUROSCIENCE

HPV16 E6 augments Wnt signaling in an E6AP-dependent manner

(2009) Hava Lichtig et al.   VIROLOGY

The comorbidity of autism with the genomic disorders of chromosome 15q11.2-q13

(2008) Amber Hogart et al.   NEUROBIOLOGY OF DISEASE