An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein

Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding

(2017) Michael D. Glidden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin

(2016) Alissa R. Segal et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Contribution of TyrB26to the Function and Stability of Insulin

(2016) Vijay Pandyarajan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Sizes of Aggregates of Insulin Analogs and the Conformations of the Constituent Protein Molecules: A Concomitant Dynamic Light Scattering and Raman Spectroscopy Study

(2016) Chen Zhou et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Pursuit of a perfect insulin

(2016) Alexander N. Zaykov et al.   NATURE REVIEWS DRUG DISCOVERY

Structural Congruency of Ligand Binding to the Insulin and Insulin/Type 1 Insulin-like Growth Factor Hybrid Receptors

(2015) John G. Menting et al.   STRUCTURE

Treatment of Diabetic Rats With Insulin or a Synthetic Insulin Receptor Agonist Peptide Leads to Divergent Metabolic Responses

(2014) Henriette Frikke-Schmidt et al.   DIABETES

Biophysical Optimization of a Therapeutic Protein by Nonstandard Mutagenesis

(2014) Vijay Pandyarajan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In This Issue

(2014)   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical Synthesis of Insulin Analogs through a Novel Precursor

(2013) Alexander N. Zaykov et al.   ACS Chemical Biology

Down-regulation of cyclin G2 by insulin, IGF-I (insulin-like growth factor 1) and X10 (AspB10 insulin): role in mitogenesis

(2013) Angela M. Svendsen et al.   BIOCHEMICAL JOURNAL

Insulin Receptor Phosphorylation by Endogenous Insulin or the Insulin Analog AspB10 Promotes Mammary Tumor Growth Independent of the IGF-I Receptor

(2013) E. J. Gallagher et al.   DIABETES

How insulin engages its primary binding site on the insulin receptor

(2013) John G. Menting et al.   NATURE

Insulin solubility transitions by pH-dependent interactions with proinsulin C-peptide

(2012) Michael Landreh et al.   FEBS Journal

Agonism and Antagonism at the Insulin Receptor

(2012) Louise Knudsen et al.   PLoS One

Insulin analog with additional disulfide bond has increased stability and preserved activity

(2012) Tine N. Vinther et al.   PROTEIN SCIENCE

Insulin Analogs and Cancer

(2012) Laura Sciacca et al.   Frontiers in Endocrinology

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Measuring steady-state and dynamic endoplasmic reticulum and Golgi Zn2+ with genetically encoded sensors

(2011) Y. Qin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integration, scaling, space-group assignment and post-refinement

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Comparison of Pharmacokinetic Properties, Physicochemical Stability, and Pump Compatibility of 3 Rapid-Acting Insulin Analogues-Aspart, Lispro, and Glulisine

(2010) Bruce Bode   Endocrine Practice

An Achilles' Heel in an Amyloidogenic Protein and Its Repair

(2010) Yanwu Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Supramolecular Protein Engineering

(2010) Nelson B. Phillips et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic potential of β-arrestin- and G protein-biased agonists

(2010) Erin J. Whalen et al.   TRENDS IN MOLECULAR MEDICINE

MCF-7 human mammary adenocarcinoma cells exhibit augmented responses to human insulin on a collagen IV surface

(2009) Nicolai Listov-Saabye et al.   JOURNAL OF APPLIED TOXICOLOGY

Enhancing the Activity of a Protein by Stereospecific Unfolding

(2009) Qing-xin Hua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice

(2009) K. Lemaire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Posttransformational vector amplification in the yeastPichia pastoris

(2008) Anthony Jay Sunga et al.   FEMS YEAST RESEARCH

Design of an Active Ultrastable Single-chain Insulin Analog

(2008) Qing-xin Hua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY