Article
Biology
Jozaa Z. ALTamimi, Nora A. AlFaris, Dalal H. Aljabryn, Reham Alagal, Ghedeir M. Alshammari, Hussain Aldera, Sultan Alqahtani, Mohammed Abdo Yahya
Summary: The study demonstrated that ellagic acid has a protective effect against testicular damage and sperm abnormalities induced by diabetes, potentially through regulating hormone levels and oxidative stress to improve reproductive function.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Alper Gurmen, Orkut Guclu, Serhat Huseyin, Nuray Can, Eray Ozgun, Mursel Buyukadali, Adem Reyhancan, Suat Canbaz
Summary: This study investigated the effects of ellagic, vanillic, and rosmarinic acid on kidney damage in an experimental lower-extremity ischemia/reperfusion (I/R) model. The results suggest that these acids may have antioxidant effects and be beneficial for renal damage after acute lower-extremity ischemia.
CARDIOVASCULAR JOURNAL OF AFRICA
(2023)
Article
Nanoscience & Nanotechnology
Peng Tang, Huiyin Wu, Mengru Wang, Ruihan Zhang, Bin Liang, Xiaoli Li, Weilie Xiao
Summary: In this study, linear poly(rosmarinic acid) nanomedicines were synthesized and showed improved therapeutic effects in the treatment of acute liver injury. This research suggests that drug-based backbone polymers provide a new approach for the development of versatile nanomedicines.
ACS APPLIED NANO MATERIALS
(2023)
Article
Multidisciplinary Sciences
Eman A. Ali, Sara G. Tayel, Mona A. Abbas
Summary: This study evaluates the potential of sitagliptin, a DPP4I drug, in ameliorating BUS-induced pulmonary and testicular injury in rats. The results show that sitagliptin reduces oxidative stress and inflammation, improves reproductive parameters, and attenuates fibrosis and apoptosis in lung and testicular tissues.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Kezheng Peng, Chenye Zeng, Yuqi Gao, Binliang Liu, Liyuan Li, Kang Xu, Yuemiao Yin, Ying Qiu, Mingkui Zhang, Fei Ma, Zhao Wang
Summary: Cardiotoxicity is a major issue in cancer therapy using anthracyclines. The expression of histone deacetylase SIRT6 was found to be reduced in patients undergoing anthracyclines-based chemotherapy. Overexpression of SIRT6 alleviated the cytotoxicity of doxorubicin in cardiomyocytes and potentiated its cytotoxicity in cancer cells. SIRT6 overexpression also ameliorated doxorubicin-induced cardiotoxicity and enhanced its antitumor efficacy in mice. These findings suggest that activating SIRT6 could be a potential strategy to prevent cardiotoxicity in cancer patients receiving chemotherapy with doxorubicin.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Pharmacology & Pharmacy
Sonja Salinger-Martinovic, Vladan Cosic, Nenad Stojiljkovic, Sonja Ilic, Nikola Stojanovic, Tijana Dencic
Summary: Ellagic acid has the potential to prevent the effects of doxorubicin on the heart in rats, but not on the thoracic aorta tissue.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Steve Harakeh, Mohammed Qari, Nisreen Rajeh, Soad Ali, Nagla El-Shitany, Saber Hassan, Elham A. Abd-Allah, Hanaa Tashkandi, Muhammad Faraz Arshad Malik, Feras Khaled Aljabri, Leena Azhar, Najiah Azhar, Soad Al-Jaouni, Yousef Almehmadi, Turki Alamri, Shaker Mousa
Summary: The study compared the protective effects of ellagic acid nanoformulation (NEL), regular ellagic acid (EL), metformin (MET), and their combination on testicular damage induced by diabetes in rats. The results showed that NEL was more effective in preventing testicular damage and apoptosis caused by diabetes, and improving spermatogenesis. NEL is recommended as a treatment option for protecting against male testicular injury associated with diabetes.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Engineering, Environmental
Jinyuan Hu, Xu Luo, Mogellah John Panga, Clara Appiah, Vladimir Retyunskiy, Lin Zhu, Ye Zhao
Summary: Zinc pyrithione (ZPT) is widely used as an antifouling, antibacterial, and antifungal agent, but it has been shown to be toxic to marine life. However, there is limited research on the toxicity and toxicological mechanism of ZPT in the reproductive systems of aquatic organisms. Our study found that ZPT exposure caused various abnormalities in zebrafish sperm and testicular tissue, including decreased testosterone levels, sperm deformities, decreased sperm concentration and motility, and DNA damage in testicular tissue. We also identified potential mechanisms of ZPT-induced testicular injury through RNA-seq analysis of differentially expressed genes (DEGs).
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Environmental Sciences
Lalrinsanga Lalrindika, Maurya Khushboo, Baishya Bhanushree, Roy Dinata, Milirani Das, Nisekhoto Nisa, Sailo Lalrinzuali, Bose Manikandan, Laskar Saeed-Ahmed, Sanasam Sanjeev, Guruswami Gurusubramanian, Rema Momin Bidanchi, Meesala Krishna Murthy, Vikas Kumar Roy
Summary: This study investigates the potential antioxidative, anti-inflammatory, and anti-apoptotic effects of ellagic acid (EA) on lead-induced testicular and hepato-renal toxicity. EA administration reduces lead residue levels in tissues, improves liver and kidney function, restores redox homeostasis, and suppresses oxidative stress, inflammatory, and apoptotic responses.
ENVIRONMENTAL POLLUTION
(2022)
Article
Multidisciplinary Sciences
T. Kloskowski, K. Szeliski, K. Krzeszowiak, Z. Fekner, L. Kazimierski, A. Jundzill, T. Drewa, M. Pokrywczynska
Summary: The study found that Mumio exhibited significant cytotoxicity to urinary bladder cancer cells, while having minimal impact on normal cells. Mumio works by inhibiting the cell cycle of cancer cells and inducing apoptosis.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Aliaa H. Ashoub, Doaa H. Abdel-Naby, Marwa M. Safar, Mona A. El-Ghazaly, Sanaa A. Kenawy
Summary: Nicotine exposure can lead to testicular toxicity and hormonal changes in rats, but treatment with fractionated low-dose radiation and ellagic acid can alleviate these negative effects.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Tina Blazevic, Gottfried Reznicek, Limin Ding, Gangqiang Yang, Patricia Haiss, Elke H. Heiss, Verena M. Dirsch, Rongxia Liu
Summary: This study demonstrates that esterification is a promising approach to enhance the in vivo bioavailability of rosmarinic acid in rats and the in vitro biological activity in rat vascular smooth muscle cells. The optimal alkyl chain length for esterification is between C1 and C4, while longer alkyl chains may lead to cytotoxicity.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Azam Hosseinzadeh, Saeed Mehrzadi, Amir Siahpoosh, Zahra Basir, Nosrat Bahrami, Mehdi Goudarzi
Summary: Ellagic acid effectively mitigated the adverse effects of DEHP on body and testes weights, sperm characteristics, and hormone levels. Furthermore, ellagic acid also reduced oxidative stress and inflammatory responses induced by DEHP in testicular tissue. These findings suggest that ellagic acid may be a promising agent in preventing male reproductive toxicity caused by endocrine disrupting chemicals such as DEHP.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Marwa Elsbaey, Mahmoud A. A. Ibrahim, Ahmed M. Shawky, Tomofumi Miyamoto
Summary: Phytochemical investigation of Eryngium creticum L. led to the isolation of five compounds, including four new compounds. Among them, a mixture of compounds showed better activity against the coronavirus, compared to a single compound. Molecular docking and molecular dynamics techniques were used to evaluate the binding affinities and features of the isolated compounds, revealing the higher binding affinity of the mixture compared to the single compound.
Article
Biochemistry & Molecular Biology
Rahul Gupta, Tinku Gupta, Dhirender Kaushik
Summary: This study aimed to investigate the effect of ellagic acid (EA) and Vitamin C on the toxicity of the pesticide malathion (MT) in the testis of rats. The results showed that EA and Vitamin C can alleviate the negative effects of the pesticide on sperm quality.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Manigandan Nagarajan, Gobichettipalayam Balasubramaniam Maadurshni, Jeganathan Manivannan
Summary: This study found that exposure to BPA exacerbates hypertension-induced pathological changes, including renal fibrosis, oxidative stress, elevated angiotensin-converting enzyme activity, dysfunction of antioxidant and tricarboxylic acid cycle enzymes, tissue lipid abnormalities, and expression of inflammatory factors. In addition, high levels of BPA have dose-dependent effects on kidney cells, including oxidative stress, mitochondrial dysfunction, and lipid peroxidation. Therefore, a precise investigation of BPA exposure in hypertensive populations is highly recommended during risk assessment.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Haiping Bao, Qiang Zhang, Yu Li, Chen Nie
Summary: In this study, the role of circDLGAP4 in Parkinson's disease (PD) was investigated. The results showed that circDLGAP4 upregulated HMGA2 by recruiting EIF4A3, thus alleviating neuronal injury in PD.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Lina Yang, Tianwei He, Yanming Yu
Summary: This study found that uric acid induces kidney injury by inducing IL-17 expression, and treatment with anti-IL-17 antibody can alleviate uric acid-induced kidney injury.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Ediandra T. Castro, Amalia G. Alves, Daniela de Bittencourt Maia, Larissa S. Magalhaes, Mariana P. Paim, Filipe Penteado, Caroline S. Gomes, Eder J. Lenardao, Cesar A. Bruning, Cristiani F. Bortolatto
Summary: This study investigated the antioxidant activity and toxicity of selenium-containing compounds in liver tissue. The results showed that these compounds have potential antioxidant effects, which can be attributed to their ability to scavenge free radicals and mimic enzyme activity. Additionally, one of the compounds exhibited low toxicity.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2024)
