Article
Cardiac & Cardiovascular Systems
Caitlin C. Fermoyle, Glenn M. Stewart, Barry A. Borlaug, Bruce D. Johnson
Summary: Patients with heart failure with preserved ejection fraction (HFpEF) exhibit lower lung diffusing capacity at rest and during exercise due to impaired gas conductance across the alveolar-capillary membrane. DLCO is impaired for a given pulmonary capillary wedge pressure and pulmonary arterial compliance. These findings provide new insights into the complex relationships between hemodynamic perturbations and gas exchange abnormalities in HFpEF.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Environmental Sciences
Rim Dridi, Nadia Dridi, Karuppasamy Govindasamy, Nabil Gmada, Ridha Aouadi, Herve Guenard, Ismail Laher, Ayoub Saeidi, Katsuhiko Suzuki, Anthony C. Hackney, Hassane Zouhal
Summary: This study found that varying aerobic training intensities have significant effects on pulmonary function in young athletes, with higher intensity training leading to greater improvements in pulmonary vascular function.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Sport Sciences
K. M. A. Thompson, A. S. D. Gamble, H. Kontro, J. B. Lee, J. F. Burr
Summary: BFR treadmill walking can increase VO2 max, and this improvement is not influenced by changes in Hb(mass) or blood volume, despite the release of blood volume regulating hormones.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Respiratory System
Apama Balasubramanian, Nirupama Putcha, Neil R. MacIntyre, Robert L. Jensen, Gregory Kinney, William W. Stlinger, Craig P. Hersh, Russell P. Bowler, Richard Casaburi, MeiLan K. Han, Janos Porszasz, R. Graham Barr, Elizabeth Regan, Barry J. Make, Nadia N. Hansel, Robert A. Wise, Meredith C. McCormack
Summary: DLCO is a potential predictor of mortality in COPD patients, independent of BODE index and CT evidence. For every 10% decrease in DLCO percent predicted, mortality increases by 28%. Adding DLCO to BODE improves the predictive accuracy of the model for COPD.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Rehabilitation
Rim Dridi, Nadia Dridi, Nabil Gmada, Ismail Laher, Ayoub Saeidi, Urs Granacher, Hassane Zouhal
Summary: This study analyzed the effects of regular soccer training on pulmonary function in boys aged 6 to 10 years. The results showed that soccer training significantly improved alveolar-capillary membrane diffusion capacity and capillary blood volume in the lungs.
BMC SPORTS SCIENCE MEDICINE AND REHABILITATION
(2023)
Article
Agriculture, Dairy & Animal Science
Ryohei Suzuki, Yunosuke Yuchi, Takahiro Saito, Yuyo Yasumura, Takahiro Teshima, Hirotaka Matsumoto, Hidekazu Koyama
Summary: This study confirms the efficacy of beraprost sodium in treating canine pulmonary hypertension and observes improvements in cardiac function and circulation.
Article
Physiology
Alessandra Magini, Gerald S. Zavorsky, Anna Apostolo, Mauro Contini, Simone Barbieri, Piergiuseppe Agostoni
Summary: In heart failure patients, the week-to-week variability in DMCO was lowest when using the single-step NO-CO technique, while Vcap estimation was unreliable. The DMCO derived from double diffusion most closely matched that from the RF method.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2021)
Article
Critical Care Medicine
Guolun Wang, Bingqiang Wen, Xiaomeng Ren, Enhong Li, Yufang Zhang, Minzhe Guo, Yan Xu, Jeffrey A. Whitsett, Tanya Kalin, Vladimir V. Kalinichenko
Summary: A unique population of pulmonary endothelial progenitor cells was identified, which can be derived from pluripotent embryonic stem cells, holding promise for the treatment of pulmonary disorders.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Xin Li, Yi Zhang, Qin Luo, Qing Zhao, Qixian Zeng, Tao Yang, Qi Jin, Lu Yan, Anqi Duan, Jiaran Liu, Chenhong An, Xiuping Ma, Changming Xiong, Zhihui Zhao, Zhihong Liu
Summary: A baseline DLCO < 70% and Delta DLCO > 6% can independently predict unfavorable responses to BPA. Dynamic measurement of DLCO facilitates the identification of patients who might have unsatisfactory hemodynamic results after BPA.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Food Science & Technology
Anita Sapoznikov, Yoav Gal, Ron Alcalay, Yentl Evgy, Tamar Sabo, Chanoch Kronman, Reut Falach
Summary: Abrin is a highly toxic protein similar to ricin in its structure and chemical properties. This study compares the kinetics of abrin and ricin intoxication in a mouse model and finds that abrin causes less damage to the lung tissue, particularly to the nonhematopoietic compartment, alveolar epithelial cells, lung endothelial cells, and intercellular junction molecules. However, both toxins show similar damage to the endothelial surface glycocalyx layer. The reduced damage to the lung stroma after exposure to abrin contributes to the high efficiency of anti-abrin antibody treatment.
Review
Respiratory System
Yingmeng Ni, Youchao Yu, Ranran Dai, Guochao Shi
Summary: DLCO % predicted is significantly lower in COPD patients with more severe airflow limitation, more symptoms, and higher exacerbation risk. It is also associated with exacerbation patients, non-survivors, emphysema dominant phenotype, and pulmonary hypertension in COPD patients. The current meta-analysis suggests that DLCO % predicted may be an important measurement for evaluating COPD patients in terms of severity, exacerbation risk, mortality, emphysema domination, and presence of pulmonary hypertension.
CHRONIC RESPIRATORY DISEASE
(2021)
Article
Cardiac & Cardiovascular Systems
Fei Sun, Guolun Wang, Arun Pradhan, Kui Xu, Jose Gomez-Arroyo, Yufang Zhang, Gregory T. Kalin, Zicheng Deng, Ronald J. Vagnozzi, Hua He, Andrew W. Dunn, Yuhua Wang, Allen J. York, Rashmi S. Hegde, Jason C. Woods, Tanya V. Kalin, Jeffery D. Molkentin, Vladimir V. Kalinichenko
Summary: Nanoparticle therapies increasing neonatal pulmonary angiogenesis may prevent pulmonary hypertension in patients with ACDMPV, improving survival rates and decreasing fibrotic lung remodeling.
Article
Cardiac & Cardiovascular Systems
Jasleen Minhas, Pietro Nardelli, Syed Moin Hassan, Nadine Al-Naamani, Eileen Harder, Samuel Ash, Gonzalo Vegas Sanchez-Ferrero, Stefanie Mason, Andetta R. Hunsaker, Gregory Piazza, Samuel Z. Goldhaber, Aaron B. Waxman, Steven M. Kawut, Raul San Jose Estepar, George R. Washko, Farbod N. Rahaghi
Summary: In patients with acute pulmonary embolism, a reduction in small venous volume measured on computed tomography angiography is associated with increased risk of abnormal right ventricle on echocardiography, higher levels of cardiac biomarkers, and higher 30- and 90-day mortality rates. These findings suggest that small venous volume could serve as a useful marker for assessing disease severity in acute pulmonary embolism.
CIRCULATION-CARDIOVASCULAR IMAGING
(2021)
Article
Physiology
Eli F. Kelley, Alex R. Carlson, Robert J. Wentz, Briana L. Ziegler, Bruce D. Johnson
Summary: The study suggests that operationally-relevant changes in inspired gas concentrations may cause acute but mild pulmonary vascular deregulation, reduced distention, and mild pulmonary-capillary vasoconstriction, without significant changes in lung fluid balance or respiratory gas exchange.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Pediatrics
Joseph J. Smolich, Michael M. H. Cheung, Jonathan P. Mynard
Summary: This study found that reducing lung liquid volume in fetal lambs led to an increase in left ventricular pump function, which was related to an increase in left ventricular preload due to the lessening of external constraint on the heart, rather than an increase in left ventricular contractility.
PEDIATRIC RESEARCH
(2021)
Article
Physiology
Glenn M. Stewart, Courtney M. Wheatley-Guy, Norman R. Morris, Kirsten E. Coffman, Jan Stepanek, Alex R. Carlson, Amine Issa, Michael A. Schmidt, Bruce D. Johnson
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2020)
Article
Physiology
Bryan J. Taylor, Brian P. Shapiro, Bruce D. Johnson
EXPERIMENTAL PHYSIOLOGY
(2020)
Article
Physiology
Karleigh E. Bradbury, Beau R. Yurkevicius, Katherine M. Mitchell, Kirsten E. Coffman, Roy M. Salgado, Charles S. Fulco, Robert W. Kenefick, Nisha Charkoudian
JOURNAL OF APPLIED PHYSIOLOGY
(2020)
Article
Sport Sciences
Kirsten E. Coffman, Adam J. Luippold, Roy M. Salgado, Kristen R. Heavens, Elizabeth M. Caruso, Charles S. Fulco, Robert W. Kenefick
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2020)
Article
Physiology
Roy M. Salgado, Kirsten E. Coffman, Karleigh E. Bradbury, Katherine M. Mitchell, Beau R. Yurkevicius, Adam J. Luippold, Thomas A. Mayer, Nisha Charkoudian, Billie K. Alba, Charles S. Fulco, Robert W. Kenefick
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2020)
Article
Biochemical Research Methods
Kirsten E. Coffman, Katherine M. Mitchell, Roy M. Salgado, Geoffrey D. Miller, Robert W. Kenefick, Samuel N. Cheuvront
DRUG TESTING AND ANALYSIS
(2020)
Article
Physiology
Roy M. Salgado, Aaron R. Caldwell, Kirsten E. Coffman, Samuel N. Cheuvront, Robert W. Kenefick
JOURNAL OF APPLIED PHYSIOLOGY
(2020)
Article
Sport Sciences
Tim A. Hardy, Stephen C. How, Bryan J. Taylor
Summary: Acute expiratory muscle loading enhances expiratory muscle function but does not improve subsequent severe-intensity exercise tolerance in healthy men.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2021)
Letter
Critical Care Medicine
Scott A. Helgeson, Augustine S. Lee, Neal M. Patel, Bryan J. Taylor, Kaiser G. Lim, Alexander S. Niven
Article
Physiology
Tim A. Hardy, Marcelle Paula-Ribeiro, Bruno M. Silva, Gemma K. Lyall, Karen M. Birch, Carrie Ferguson, Bryan J. Taylor
Summary: The research found that fatiguing expiratory muscle work in otherwise resting humans did not affect group mean limb blood flow and leg vascular resistance. However, within-breath oscillations in limb blood flow may reflect a sympathetically mediated vasoconstriction that was counteracted by transient increases in blood flow due to the mechanical effects of high intra-abdominal pressure during resistive loaded breathing.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Critical Care Medicine
Scott A. Helgeson, Bryan J. Taylor, Kaiser G. Lim, Augustine S. Lee, Alexander S. Niven, Neal M. Patel
Summary: Using a light-scattering particle counter, the study found significant increases in both small and large micrometer-size particle generation during cardiopulmonary rehabilitation classes, despite participants wearing procedural masks. The increase in particle generation was more pronounced in classes with larger numbers of patients.
Article
Public, Environmental & Occupational Health
Troy J. Cross, Jennifer M. J. Isautier, Sarah J. Morris, Bruce D. Johnson, Courtney M. Wheatley-Guy, Bryan J. Taylor
Summary: Based on the findings of our study, we suggest that future public health messaging of social distancing guidelines should include (1) a clear portrayal of the benefits of regular exercise on mental health; and (2) a specific focus on how to be physically active outdoors in a COVID-safe manner.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2021)
Review
Cardiac & Cardiovascular Systems
Joshua R. Smith, Bryan J. Taylor
Summary: Exercise limitation is a common manifestation of cardiovascular diseases and can be improved through exercise-based cardiac rehabilitation. Inspiratory muscle dysfunction is a underestimated complication of cardiovascular diseases that contributes to breathlessness and exercise intolerance. This review explores the prevalence of inspiratory muscle weakness, its impact on physiological function and clinical outcomes, and evaluates the effects of exercise-based cardiac rehabilitation on inspiratory muscle function in patients with cardiovascular diseases. The assessment of global respiratory muscle function and implementation of inspiratory muscle training are recommended for phase II cardiac rehabilitation programs.
PROGRESS IN CARDIOVASCULAR DISEASES
(2022)
Review
Physiology
Robyn Bryde, Andres Applewhite, Abd Moain Abu Dabrh, Bryan J. Taylor, Michael G. Heckman, Sara E. Filmalter, George Pujalte, Carlos Rojas, Alexander J. Heckman, Tara J. Brigham, Larry J. Prokop, Brian P. Shapiro
Summary: The meta-analysis showed that chronic exercise exposure in female elite athletes may lead to cardiac chamber enlargement and increased stroke volume. Left ventricular and right ventricular dimensional, volumetric, and functional assessments were greater in endurance athletes compared to healthy controls. The changes in cardiac structure and function in female athletes were similar to those in male counterparts, with the right ventricle possibly being more susceptible to enlargement.
PHYSIOLOGICAL REPORTS
(2021)
Article
Physiology
Mirelle I. I. Schoeberlein, Catherine E. E. Frisiras, Kirsten E. E. Coffman
Summary: This study aimed to quantify the combined effects of heat exposure and exercise of increasing intensity on pulmonary blood flow using lung diffusing capacity for carbon monoxide (DLCO) as an indirect measure. The results showed that DLCO increased during exercise in the heat condition, possibly due to increased pulmonary capillary recruitment and/or distension secondary to a higher cardiac output (Q) in the heat. This study furthers our understanding of how heat exposure might impact pulmonary blood flow, specifically as assessed via DLCO.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)