Article
Rehabilitation
Rim Dridi, Nadia Dridi, Nabil Gmada, Ismail Laher, Ayoub Saeidi, Urs Granacher, Hassane Zouhal
Summary: This study analyzed the effects of regular soccer training on pulmonary function in boys aged 6 to 10 years. The results showed that soccer training significantly improved alveolar-capillary membrane diffusion capacity and capillary blood volume in the lungs.
BMC SPORTS SCIENCE MEDICINE AND REHABILITATION
(2023)
Article
Cardiac & Cardiovascular Systems
Caitlin C. Fermoyle, Glenn M. Stewart, Barry A. Borlaug, Bruce D. Johnson
Summary: Patients with heart failure with preserved ejection fraction (HFpEF) exhibit lower lung diffusing capacity at rest and during exercise due to impaired gas conductance across the alveolar-capillary membrane. DLCO is impaired for a given pulmonary capillary wedge pressure and pulmonary arterial compliance. These findings provide new insights into the complex relationships between hemodynamic perturbations and gas exchange abnormalities in HFpEF.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Physiology
Eli F. Kelley, Alex R. Carlson, Robert J. Wentz, Briana L. Ziegler, Bruce D. Johnson
Summary: The study suggests that operationally-relevant changes in inspired gas concentrations may cause acute but mild pulmonary vascular deregulation, reduced distention, and mild pulmonary-capillary vasoconstriction, without significant changes in lung fluid balance or respiratory gas exchange.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ali Doryab, Mehmet Berat Taskin, Philipp Stahlhut, Andreas Schroeppel, Darcy E. Wagner, Juergen Groll, Otmar Schmid
Summary: The study presents a bioinspired lung membrane that can mimic the complex environment of the lung, with good stretchability and surface properties for culturing lung epithelial cells. Physiological cyclic stretch improves cell structure and function, while non-physiological over-stretch leads to cell death and inflammatory response.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Critical Care Medicine
Guolun Wang, Bingqiang Wen, Xiaomeng Ren, Enhong Li, Yufang Zhang, Minzhe Guo, Yan Xu, Jeffrey A. Whitsett, Tanya Kalin, Vladimir V. Kalinichenko
Summary: A unique population of pulmonary endothelial progenitor cells was identified, which can be derived from pluripotent embryonic stem cells, holding promise for the treatment of pulmonary disorders.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Food Science & Technology
Anita Sapoznikov, Yoav Gal, Ron Alcalay, Yentl Evgy, Tamar Sabo, Chanoch Kronman, Reut Falach
Summary: Abrin is a highly toxic protein similar to ricin in its structure and chemical properties. This study compares the kinetics of abrin and ricin intoxication in a mouse model and finds that abrin causes less damage to the lung tissue, particularly to the nonhematopoietic compartment, alveolar epithelial cells, lung endothelial cells, and intercellular junction molecules. However, both toxins show similar damage to the endothelial surface glycocalyx layer. The reduced damage to the lung stroma after exposure to abrin contributes to the high efficiency of anti-abrin antibody treatment.
Article
Cardiac & Cardiovascular Systems
Fei Sun, Guolun Wang, Arun Pradhan, Kui Xu, Jose Gomez-Arroyo, Yufang Zhang, Gregory T. Kalin, Zicheng Deng, Ronald J. Vagnozzi, Hua He, Andrew W. Dunn, Yuhua Wang, Allen J. York, Rashmi S. Hegde, Jason C. Woods, Tanya V. Kalin, Jeffery D. Molkentin, Vladimir V. Kalinichenko
Summary: Nanoparticle therapies increasing neonatal pulmonary angiogenesis may prevent pulmonary hypertension in patients with ACDMPV, improving survival rates and decreasing fibrotic lung remodeling.
Review
Physiology
Filipe Rios Drummond, Luciano Bernardes Leite, Denise Coutinho de Miranda, Lucas Rios Drummond, Victor Neiva Lavorato, Leoncio Lopes Soares, Clovis Andrade Neves, Antonio Jose Natali
Summary: Pulmonary arterial hypertension is associated with skeletal muscle myopathy and atrophy and impaired exercise tolerance. Aerobic exercise training has been recommended as a non-pharmacological therapy for deleterious effects imposed by pulmonary arterial hypertension. This minireview highlights the pathways involved in skeletal muscle adaptations to aerobic exercise training in patients with pulmonary arterial hypertension.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Materials Science, Biomaterials
Michela Licciardello, Viola Sgarminato, Gianluca Ciardelli, Chiara Tonda-Turo
Summary: This study developed two biomimetic in vitro models using tissue engineering approaches to mimic the physiological features of the alveolar-capillary barrier. The models were able to accurately reproduce the characteristics of the barrier and could be used for testing and validation of therapeutic approaches for lung disease.
BIOMATERIALS ADVANCES
(2023)
Review
Geriatrics & Gerontology
Tsubasa Tomoto, Rong Zhang
Summary: Advanced age is a major risk factor for dementia, including Alzheimer's disease. Arterial aging is closely associated with cerebrovascular dysfunction and brain aging, while aerobic exercise can improve cerebral blood flow and cerebrovascular function, thereby maintaining brain health in older adults.
Article
Engineering, Chemical
Antoine Venault, Yi-Tung Chin, Irish Maggay, Chih-Chen Yeh, Yung Chang
Summary: This work investigates the association of P(S-r-AA) copolymer with PVDF in the fabrication of electrospun fibers for blood filtration, showing improved wetting of nanofibers and enhanced separation and retention of white blood cells. The results demonstrate the potential of PVDF-based nanofibers as efficient separation media for whole blood, with further efforts needed to enhance biocompatibility and red blood cell recovery.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Andreas Seraphim, Kristopher D. Knott, Katia Menacho, Joao B. Augusto, Rhodri Davies, Iain Pierce, George Joy, Anish N. Bhuva, Hui Xue, Thomas A. Treibel, Jackie A. Cooper, Steffen E. Petersen, Marianna Fontana, Alun D. Hughes, James C. Moon, Charlotte Manisty, Peter Kellman
Summary: This study explores the prognostic significance of PTT and PBVi using an automated method with CMR. The results show that these parameters can independently predict adverse cardiovascular outcomes, offering additional insights into cardiopulmonary function.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Sport Sciences
K. M. A. Thompson, A. S. D. Gamble, H. Kontro, J. B. Lee, J. F. Burr
Summary: BFR treadmill walking can increase VO2 max, and this improvement is not influenced by changes in Hb(mass) or blood volume, despite the release of blood volume regulating hormones.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Anders Nelsson, Mikael Kanski, Henrik Engblom, Martin Ugander, Marcus Carlsson, Hakan Arheden
Summary: Increased pulmonary blood volume (PBV) is a measure of congestion and is associated with an increased risk of cardiovascular events. This study aimed to determine the accuracy and precision for different methods of quantifying PBV, finding that adjusting for left atrium volume (LAV) is crucial for more accurate results. Among the methods tested, CoG(FPP) had the best precision and lowest interobserver variability for measuring PBV.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2021)
Article
Physiology
Brandon S. Shaw, Rohan Lloyd, Monica Da Silva, Donne Coetzee, Jason Moran, Sally P. W. Waterworth, Musa L. Mathunjwa, Ina Shaw
Summary: This study evaluated the efficacy of German Volume Training (GVT) in health settings and found that GVT significantly decreased blood pressure while increasing heart rate and perceived exertion. This suggests that GVT can be used in various health promotion settings.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Geriatrics & Gerontology
Ebrahim Banitalebi, Elahe Banitalebi, Majid Mardaniyan Ghahfarokhi, Mostafa Rahimi, Ismail Laher, Kade Davison
Summary: This study aimed to evaluate the effects of resistance elastic band exercises (REBEs) on cardiometabolic/obesity-related biomarkers in older females with osteosarcopenic obesity. A total of 63 patients aged 65-80 years with osteosarcopenic obesity and a body mass index exceeding 30 kg/m2 were randomly assigned to either an experimental group (REBE, n = 32) or a usual care group (n = 31). The experimental group completed a 12-week REBE program, three times a week and 60 min per session. Compared with the usual care group, the experimental group showed decreases in lipid accumulation product (p = .033), visceral adipose index (p = .001), triglyceride-glucose-body mass index (p = .034), and atherogenic index of plasma (p = .028). The findings highlight the importance of an REBE program in improving combined cardiometabolic/obesity-related indices in older women with osteosarcopenic obesity, especially for those who cannot tolerate or participate in more strenuous exercise programs.
JOURNAL OF AGING AND PHYSICAL ACTIVITY
(2023)
Article
Medicine, Research & Experimental
Saeed Daneshyar, Gholamreza Tavoosidana, Mahdi Bahmani, Saeed Shokati Basir, Maryam Delfan, Ismail Laher, Ayoub Saeidi, Urs Granacher, Hassane Zouhal
Summary: This study aims to investigate the combined effects of high-fat diets and exercise training on autophagy in mouse white adipose tissue. The results show that both the high-fat diet and exercise training groups had increased levels of autophagy-related genes and proteins. The combination of high-fat diet and exercise enhances autophagosome formation and modulates lysosomal degradation in white adipose tissue.
Article
Nutrition & Dietetics
Hossein Shirvani, Behzad Bazgir, Alireza Shamsoddini, Ayoub Saeidi, Seyed Morteza Tayebi, Kurt A. A. Escobar, Ismail Laher, Trisha A. A. VanDusseldorp, Katja Weiss, Beat Knechtle, Hassane Zouhal
Summary: This study investigated the effects of oregano supplementation on muscle damage, oxidative stress, and plasma antioxidant markers of soldiers performing military training. The results showed that oregano supplementation can reduce muscle damage and increase oxidative capacity. Therefore, supplementation with oregano may serve as a dietary strategy to increase preparedness and promote recovery in military recruits.
Article
Nutrition & Dietetics
Manda Wang, Gangqiang Wang, Xiaoli Pang, Jiacheng Ma, Jinghan Yuan, Yanrong Pan, Yu Fu, Ismail Laher, Shunchang Li
Summary: Cardiac structure remodeling and dysfunction are common complications of diabetes, often leading to serious cardiovascular events. MOTS-c, a mitochondria-derived peptide, regulates metabolic homeostasis and improves vascular endothelial function, making it a novel therapeutic target for the cardiovascular complications of diabetes.
FRONTIERS IN NUTRITION
(2023)
Article
Physiology
Noriaki Kawanishi, Takaki Tominaga, Katsuhiko Suzuki
Summary: This study found that resistance exercise, specifically electrical pulse stimulation-induced muscle contraction, resulted in changes in the miRNA and mRNA profiles of circulating extracellular vesicles. Muscle-specific miRNAs such as miR-1, miR-133, and miR-206 showed significant upregulation after 90 minutes of muscle contraction. Additionally, mRNA expression changes in circulating extracellular vesicles after muscle contraction were found to promote angiogenesis and regulate the immune response. These changes in extracellular vesicle properties may play a crucial role in resistance exercise-induced physiological adaptations.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2023)
Review
Obstetrics & Gynecology
Claire Tourny, Amira Zouita, Samira El Kababi, Lea Feuillet, Ayoub Saeidi, Ismail Laher, Katja Weiss, Beat Knechtle, Hassane Zouhal
Summary: This article reviews the effects of physical activity on the management and quality of life in patients with endometriosis. The findings suggest that body awareness practices such as Hatha yoga and progressive muscle relaxation can reduce pain and stress and improve the quality of life associated with endometriosis. However, caution should be taken in considering patients' physical abilities and avoiding intense physical activities. More research is needed to explore nonmedicinal or surgical techniques for different forms of endometriosis and its symptoms.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Biochemistry & Molecular Biology
Takaki Tominaga, Jiapeng Huang, Shuo Wang, Miwa Noguchi, Yishan Tong, Momoko Asano-Oritani, Katsuhiko Suzuki
Summary: Several food components, including polyphenols and phytonutrients, have immunomodulatory effects. Collagen, known for its various bioactivities, can promote wound healing and relieve symptoms of bone/joint disease. This study investigated the immunomodulatory effects of collagen-derived dipeptides and amino acids on macrophages and peripheral blood mononuclear cells (PBMC), and found that there is no difference in cytokine secretion between dipeptides and amino acids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shiori Wakasugi-Onogi, Sihui Ma, Ruheea Taskin Ruhee, Yishan Tong, Yasuhiro Seki, Katsuhiko Suzuki
Summary: This study found that sulforaphane has various effects on neutrophil functions, including inhibiting reactive oxygen species (ROS) production, degranulation, phagocytosis, and neutrophil extracellular trap (NET) formation. Sulforaphane also has direct antioxidant activity. It was observed that sulforaphane can decrease the release of inflammatory cytokines and myeloperoxidase from neutrophils. In addition, sulforaphane directly removes ROS, including hypochlorous acid (HOCl).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Sport Sciences
Bahram Sheikhi, Amir Letafatkar, Paulo Henrique Marchetti, Fereshteh Eftekhari, Brian J. Wallace, Filippo Maselli, Giacomo Rossettini, Urs Granacher, Hassane Zouhal
Summary: This study aimed to examine the immediate and delayed effects of kinesio taping at different stretches on tuck jump performance in active individuals. However, the results showed no improvement in tuck jump performance after the application of kinesio taping, regardless of the stretch level. There were no significant differences in tuck jump performance between the different kinesio taping groups at any time point.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2023)
Article
Sport Sciences
Ammar Nebigh, Imed Touhami, Mokhtar Chtara, Karuppasamy Govindasamy, Chandrababu Surech, Rawad El Hage, Ayoub Saeidi, Daniel Boullosa, Cain C. T. Clark, Urs Granacher, Hassane Zouhal
Summary: This study aimed to investigate the impact of sex and sport-discipline on physical fitness and bone markers in young sub-elite track and field athletes. The results showed significant differences in bone markers between males and females, with higher levels observed in males. Additionally, there was a significant difference in bone marker levels between athletes in endurance and power sports, with endurance athletes having higher levels.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2023)
Article
Physiology
Raoua Triki, Hassane Zouhal, Hamdi Chtourou, Iyed Salhi, Nidhal Jebabli, Ayoub Saeidi, Ismail Laher, Anthony C. Hackney, Urs Granacher, Abderraouf Ben Abderrahman
Summary: This study investigated the effects of timing of resistance training (RT) during Ramadan intermittent fasting (RIF) on muscle strength and hypertrophy in healthy male adults. The results suggest that practicing RT during RIF does not have adverse effects on muscle hypertrophy and strength, regardless of whether it is done in a fed or fasted state. However, RT has greater effects on muscle strength when done in a fed state. Therefore, training sessions during Ramadan should be scheduled after breaking the fast.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2023)
Review
Sport Sciences
Amira Zouita, Manel Darragi, Mariem Bousselmi, Zouita Sghaeir, Cain C. T. Clark, Anthony C. Hackney, Urs Granacher, Hassane Zouhal
Summary: This systematic review summarizes the recent evidence on the long-term effects of resistance training on muscular fitness, muscle morphology, and body composition in female elite athletes. The findings suggest that resistance training leads to significant improvements in muscle power, strength, speed, and jump performance in this population. However, further research is needed to determine the optimal training parameters for maximizing these outcomes in female elite athletes.
Article
Biochemistry & Molecular Biology
Hiroaki Sako, Mohieldin Youssef, Olga Elisseeva, Takayuki Akimoto, Katsuhiko Suzuki, Takashi Ushida, Tadashi Yamamoto
Summary: Slower translation rates reduce protein misfolding by allowing time for proper folding. MicroRNAs (miRNAs), which are absent in prokaryotes, can stall translating ribosomes, preventing misfolding with little effect on protein abundance. This eukaryote-specific mechanism provides insights into co-translational protein folding and has potential in targeting protein misfolding diseases.
Article
Medicine, General & Internal
Mahsa Naghashpour, Dian Dayer, Hadi Karami, Mahshid Naghashpour, Mahin Taheri Moghadam, Seyed Mohammad Jafar Haeri, Katsuhiko Suzuki
Summary: This study demonstrates that magnolol has a significant anti-tumor effect on MKN-45 cells and can be used to overcome cisplatin resistance in gastric cancer cells when combined with cisplatin.
MEDICINA-LITHUANIA
(2023)
Article
Rehabilitation
Mohamed Amine Ltifi, Hassane Zouhal, Ismail Laher, Ayoub Saeidi, Karuppasamy Govindasamy, Urs Granacher, Ridha Aouadi, Abderraouf Ben Abderrahman
Summary: This study found that wearing lower extremity WRs with micro-loads of 0.1% or 0.2% of body mass can attenuate physical fatigue indicated in attenuated RCoD performance while executing SSG.
BMC SPORTS SCIENCE MEDICINE AND REHABILITATION
(2023)