Challenges and discoveries in the total synthesis of complex polyketide natural products

An Expedient Total Synthesis of Chivosazole F: an Actin-Binding Antimitotic Macrolide from the MyxobacteriumSorangium Cellulosum

(2016) Simon Williams et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Leiodermatolide, a novel marine natural product, has potent cytotoxic and antimitotic activity against cancer cells, appears to affect microtubule dynamics, and exhibits antitumor activity

(2016) Esther A. Guzmán et al.   INTERNATIONAL JOURNAL OF CANCER

Strategy Evolution in the Total Synthesis of (−)-Leiodermatolide

(2016) Ian Paterson et al.   ISRAEL JOURNAL OF CHEMISTRY

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Toward Leiodermatolide: Synthesis of the Core Structure

(2016) Anita Reiss et al.   ORGANIC LETTERS

Total Synthesis of the Antimitotic Marine Macrolide (−)-Leiodermatolide

(2014) Ian Paterson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis, Molecular Editing, and Biological Assessment of the Potent Cytotoxin Leiodermatolide

(2014) Damien Mailhol et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of the C1–C18 Fragment of Rhizopodin: Late-State Introduction of the Oxazole

(2014) Tobias Bender et al.   ORGANIC LETTERS

Formal Synthesis of Actin Binding Macrolide Rhizopodin

(2014) Kiran Kumar Pulukuri et al.   ORGANIC LETTERS

The Impact of the Mukaiyama Aldol Reaction in Total Synthesis

(2013) S. B. Jennifer Kan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of (−)-Rhizopodin

(2013) Stephen M. Dalby et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Total Synthesis of Spirastrellolide A Methyl Ester

(2013) Alexander Arlt et al.   CHEMISTRY-A EUROPEAN JOURNAL

Modular Total Synthesis of Rhizopodin: A Highly Potent G-Actin Dimerizing Macrolide

(2013) Manuel Kretschmer  et al.   CHEMISTRY-A EUROPEAN JOURNAL

Total synthesis of (+)-spirastrellolide A methyl ester: Challenges and discoveries

(2013) Ian Paterson et al.   PURE AND APPLIED CHEMISTRY

A Second-Generation Total Synthesis of Spirastrellolide A Methyl Ester

(2012) Ian Paterson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of Rhizopodin

(2012) Michael Dieckmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Divergent Total Synthesis of the Antimitotic Agent Leiodermatolide

(2012) Jens Willwacher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The stereocontrolled total synthesis of spirastrellolide A methyl ester. Fragment coupling studies and completion of the synthesis

(2012) Ian Paterson et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The stereocontrolled total synthesis of spirastrellolide A methyl ester. Expedient construction of the key fragments

(2012) Ian Paterson et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Stereoselective Synthesis of the Monomeric Unit of Actin Binding Macrolide Rhizopodin

(2012) Kiran Kumar Pulukuri et al.   ORGANIC LETTERS

Total Synthesis and Biological Evaluation of Monorhizopodin and 16-epi-Monorhizopodin

(2011) K. C. Nicolaou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Second-Generation Total Synthesis of Spirastrellolide F Methyl Ester: The Alkyne Route

(2011) Stefan Benson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Leiodermatolide, a Potent Antimitotic Macrolide from the Marine Sponge Leiodermatium sp.

(2011) Ian Paterson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Approach to the Core Structure of Leiodermatolide

(2011) Christian Rink et al.   ORGANIC LETTERS

Synthesis of the Macrocyclic Core of Leiodermatolide

(2011) Ian Paterson et al.   ORGANIC LETTERS

Assigning Stereochemistry to Single Diastereoisomers by GIAO NMR Calculation: The DP4 Probability

(2010) Steven G. Smith et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of Chivosazole F

(2010) Tobias Brodmann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of the C15−C35 Northern Hemisphere Subunit of the Chivosazoles

(2010) Ian Paterson et al.   ORGANIC LETTERS

Synthesis of the C9−C23 (C9′−C23′) Fragment of the Dimeric Natural Product Rhizopodin

(2010) Zheng Chen et al.   ORGANIC LETTERS

Synthesis of the C1−C13 Tetraenoate Subunit of the Chivosazoles

(2010) Ian Paterson et al.   ORGANIC LETTERS

Total Synthesis of Spirastrellolide F Methyl Ester—Part 1: Strategic Considerations and Revised Approach to the Southern Hemisphere

(2009) Gregory W. O'Neil et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of Spirastrellolide F Methyl Ester—Part 2: Macrocyclization and Completion of the Synthesis

(2009) Stefan Benson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent Advances in the Total Synthesis of Polyketide Natural Products as Promising Anticancer Agents

(2009) Ian Paterson et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Chivosazoles A and F, Cytostatic Macrolides from Myxobacteria, Interfere with Actin

(2009) Randi Diestel et al.   CHEMBIOCHEM

The therapeutic potential of phosphatase inhibitors

(2009) Viktor V Vintonyak et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Synthesis and stereochemical determination of the spirastrellolides

(2009) Ian Paterson et al.   NATURAL PRODUCT REPORTS

Total Synthesis of Spirastrellolide A Methyl Ester—Part 2: Subunit Union and Completion of the Synthesis

(2008) Ian Paterson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of Spirastrellolide A Methyl Ester—Part 1: Synthesis of an Advanced C17–C40 Bis-spiroacetal Subunit

(2008) Ian Paterson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of (−)-Reidispongiolide A, an Actin-Targeting Macrolide Isolated from the Marine SpongeReidispongia coerulea

(2008) Ian Paterson et al.   Chemistry-An Asian Journal

Isolation and structure revision of the actin-binding macrolide rhizopodin from Myxococcus stipitatus (Myxobacteria)

(2008) Rolf Jansen et al.   TETRAHEDRON LETTERS