Blood-Based Oligomeric and Other Protein Variant Biomarkers to Facilitate Pre-Symptomatic Diagnosis and Staging of Alzheimer’s Disease

Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis

(2015) Kirsten L. Viola et al.   ACTA NEUROPATHOLOGICA

Oligomeric α-synuclein and β-amyloid variants as potential biomarkers for Parkinson's and Alzheimer's diseases

(2015) Stephanie M. Williams et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Biomarkers for Alzheimer's disease: a controversial topic

(2015) Giovanni B Frisoni et al.   LANCET NEUROLOGY

Longitudinal assessment of neuroimaging and clinical markers in autosomal dominant Alzheimer's disease: a prospective cohort study

(2015) Wai-Ying Wendy Yau et al.   LANCET NEUROLOGY

Spreading of pathology in neurodegenerative diseases: a focus on human studies

(2015) Johannes Brettschneider et al.   NATURE REVIEWS NEUROSCIENCE

Isolation and characterization of antibody fragments selective for toxic oligomeric tau

(2015) Huilai Tian et al.   NEUROBIOLOGY OF AGING

Arizona Study of Aging and Neurodegenerative Disorders and Brain and Body Donation Program

(2015) Thomas G. Beach et al.   NEUROPATHOLOGY

Blood-Based Proteomic Biomarkers of Alzheimer’s Disease Pathology

(2015) Alison L. Baird et al.   Frontiers in Neurology

TDP-43 is a key player in the clinical features associated with Alzheimer’s disease

(2014) Keith A. Josephs et al.   ACTA NEUROPATHOLOGICA

Immunotherapy for Alzheimer's disease

(2014) Thomas Wisniewski et al.   BIOCHEMICAL PHARMACOLOGY

Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers

(2014) Christiane Reitz et al.   BIOCHEMICAL PHARMACOLOGY

Therapeutic approaches against common structural features of toxic oligomers shared by multiple amyloidogenic proteins

(2014) Marcos J. Guerrero-Muñoz et al.   BIOCHEMICAL PHARMACOLOGY

A Sensitive phage-based capture ELISA for sub-femtomolar detection of protein variants directly from biological samples

(2014) Stephanie Williams et al.   BIOTECHNOLOGY PROGRESS

Novel plasma biomarker surrogating cerebral amyloid deposition

(2014) Naoki KANEKO et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patients

(2014) Yu-Sheng Fang et al.   Nature Communications

Detection of Misfolded Aβ Oligomers for Sensitive Biochemical Diagnosis of Alzheimer’s Disease

(2014) Natalia Salvadores et al.   Cell Reports

Combined Plasma Biomarkers for Diagnosing Mild Cognition Impairment and Alzheimer’s Disease

(2013) Ming-Jang Chiu et al.   ACS Chemical Neuroscience

The intersection of amyloid beta and tau in glutamatergic synaptic dysfunction and collapse in Alzheimer's disease

(2013) Johanna L. Crimins et al.   AGEING RESEARCH REVIEWS

New ELISAs with high specificity for soluble oligomers of amyloid β-protein detect natural Aβ oligomers in human brain but not CSF

(2013) Ting Yang et al.   Alzheimers & Dementia

Changes in plasma amyloid beta in a longitudinal study of aging and Alzheimer's disease

(2013) Alan Rembach et al.   Alzheimers & Dementia

Tau-aggregation inhibitor therapy for Alzheimer's disease

(2013) Claude M. Wischik et al.   BIOCHEMICAL PHARMACOLOGY

Isolation and characterization of antibody fragments selective for specific protein morphologies from nanogram antigen samples

(2013) Srinath Kasturirangan et al.   BIOTECHNOLOGY PROGRESS

Deleterious effects of soluble amyloid-β oligomers on multiple steps of synaptic vesicle trafficking

(2013) Joohyun Park et al.   NEUROBIOLOGY OF DISEASE

A role for tau at the synapse in Alzheimer's disease pathogenesis

(2013) Amy M. Pooler et al.   NEUROPHARMACOLOGY

Increased Levels of Antigen-Bound β-Amyloid Autoantibodies in Serum and Cerebrospinal Fluid of Alzheimer’s Disease Patients

(2013) Madalina Maftei et al.   PLoS One

Plasma amyloid beta measurements - a desired but elusive Alzheimer's disease biomarker

(2013) Jon B Toledo et al.   Alzheimers Research & Therapy

Improved protocol for measurement of plasma β-amyloid in longitudinal evaluation of Alzheimer’s Disease Neuroimaging Initiative study patients

(2012) Michal J. Figurski et al.   Alzheimers & Dementia

Plasma amyloid-β oligomers level is a biomarker for Alzheimer’s disease diagnosis

(2012) L. Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tau oligomers and tau toxicity in neurodegenerative disease

(2012) Sarah M. Ward et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Neurochemical biomarkers in Alzheimer’s disease and related disorders

(2012) Mirko Bibl et al.   Therapeutic Advances in Neurological Disorders

TDP-43: the relationship between protein aggregation and neurodegeneration in amyotrophic lateral sclerosis and frontotemporal lobar degeneration

(2011) Robert H. Baloh   FEBS Journal

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease

(2011) Sergio T. Ferreira et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Inhibiting β-Secretase Activity in Alzheimer's Disease Cell Models with Single-Chain Antibodies Specifically Targeting APP

(2010) Shanta Boddapati et al.   JOURNAL OF MOLECULAR BIOLOGY

Age-dependent changes in TDP-43 levels in a mouse model of Alzheimer disease are linked to Aβ oligomers accumulation

(2010) Antonella Caccamo et al.   Molecular Neurodegeneration

Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives

(2010) Harald Hampel et al.   NATURE REVIEWS DRUG DISCOVERY

Nanobody specific for oligomeric beta-amyloid stabilizes nontoxic form

(2010) Srinath Kasturirangan et al.   NEUROBIOLOGY OF AGING

Identifying and validating biomarkers for Alzheimer's disease

(2010) Christian Humpel   TRENDS IN BIOTECHNOLOGY

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY

The Sun Health Research Institute Brain Donation Program: Description and Eexperience, 1987–2007

(2008) Thomas G. Beach et al.   CELL AND TISSUE BANKING

Anti-oligomeric Aβ Single-chain Variable Domain Antibody Blocks Aβ-induced Toxicity Against Human Neuroblastoma Cells

(2008) Andleeb Zameer et al.   JOURNAL OF MOLECULAR BIOLOGY

Characterisation of two antibodies to oligomeric Aβ and their use in ELISAs on human brain tissue homogenates

(2008) Zoë van Helmond et al.   JOURNAL OF NEUROSCIENCE METHODS

Mechanisms of Hybrid Oligomer Formation in the Pathogenesis of Combined Alzheimer's and Parkinson's Diseases

(2008) Igor F. Tsigelny et al.   PLoS One