Apomorphine Therapy for Neuronal Insulin Resistance in a Mouse Model of Alzheimer’s Disease

Phase 3 solanezumab trials: Secondary outcomes in mild Alzheimer's disease patients

(2016) Eric R. Siemers et al.   Alzheimers & Dementia

DPP-4 Inhibitor Linagliptin Attenuates Aβ-induced Cytotoxicity through Activation of AMPK in Neuronal Cells

(2015) Edy Kornelius et al.   CNS Neuroscience & Therapeutics

Mechanisms of Neurodegeration in Type 2 Diabetes and the Neuroprotective Potential of Dipeptidyl Peptidase 4 Inhibitors

(2015) E. Matteucci et al.   CURRENT MEDICINAL CHEMISTRY

Age-dependent impairment of glucose tolerance in the 3xTg-AD mouse model of Alzheimer’s disease

(2015) Milene Vandal et al.   FASEB JOURNAL

Exendin-4, a Glucagon-Like Peptide-1 Receptor Agonist, Reduces Alzheimer Disease-Associated Tau Hyperphosphorylation in the Hippocampus of Rats With Type 2 Diabetes

(2015) Weijie Xu et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Current and future implications of basic and translational research on amyloid-β peptide production and removal pathways

(2015) C. Bohm et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Apomorphine: A potential modifier of amyloid deposition in Parkinson's disease?

(2015) Alison J. Yarnall et al.   MOVEMENT DISORDERS

The role of type 2 diabetes in neurodegeneration

(2015) Giuseppe Verdile et al.   NEUROBIOLOGY OF DISEASE

Immunotherapeutic Approaches for Alzheimer’s Disease

(2015) Thomas Wisniewski et al.   NEURON

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease

(2015) Sergio T. Ferreira et al.   Frontiers in Cellular Neuroscience

Aberrant insulin signaling in Alzheimer's disease: current knowledge

(2015) Gaurav Bedse et al.   Frontiers in Neuroscience

Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer’s disease and tauopathies

(2014) Mark Yarchoan et al.   ACTA NEUROPATHOLOGICA

Insulin Reverses the High-Fat Diet-Induced Increase in Brain A  and Improves Memory in an Animal Model of Alzheimer Disease

(2014) M. Vandal et al.   DIABETES

Tau-Based Therapeutic Approaches for Alzheimer's Disease - A Mini-Review

(2014) Allal Boutajangout et al.   GERONTOLOGY

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

(2014) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of insulin receptor substrate-1 by mTORC2 (mammalian target of rapamycin complex 2): Figure 1

(2013) Michael A. DeStefano et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Altered Expression of Diabetes-Related Genes in Alzheimer's Disease Brains: The Hisayama Study

(2013) Masaaki Hokama et al.   CEREBRAL CORTEX

Vildagliptin: an anti-diabetes agent ameliorates cognitive deficits and pathology observed in streptozotocin-induced Alzheimer's disease

(2013) Jayasankar Kosaraju et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Saxagliptin: A dipeptidyl peptidase-4 inhibitor ameliorates streptozotocin induced Alzheimer's disease

(2013) Jayasankar Kosaraju et al.   NEUROPHARMACOLOGY

Pioglitazone Improves Reversal Learning and Exerts Mixed Cerebrovascular Effects in a Mouse Model of Alzheimer’s Disease with Combined Amyloid-β and Cerebrovascular Pathology

(2013) Panayiota Papadopoulos et al.   PLoS One

Increased Aβ production prompts the onset of glucose intolerance and insulin resistance

(2012) Margarita Jiménez-Palomares et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of long-term treatment with pioglitazone on cognition and glucose metabolism of PS1-KI, 3xTg-AD and wild-type mice

(2012) F Masciopinto et al.   Cell Death & Disease

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice

(2011) Mikko Hiltunen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Environmental enrichment ameliorated high-fat diet-induced Aβ deposition and memory deficit in APP transgenic mice

(2011) Masato Maesako et al.   NEUROBIOLOGY OF AGING

Modulation of GSK-3 as a Therapeutic Strategy on Tau Pathologies

(2011) Miguel Medina et al.   Frontiers in Molecular Neuroscience

Apomorphine treatment in Alzheimer mice promoting amyloid-β degradation

(2010) Eri Himeno et al.   ANNALS OF NEUROLOGY

How does diabetes accelerate Alzheimer disease pathology?

(2010) Catrina Sims-Robinson et al.   Nature Reviews Neurology

High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model

(2008) Carl Julien et al.   NEUROBIOLOGY OF AGING