Journal
CYTOKINE
Volume 76, Issue 1, Pages 53-57Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2015.07.026
Keywords
IL-12; Dendritic cells; Innate activation; T cell differentiation; Hypothesis; Immunological class; Tissue immunity
Funding
- NIAID NIH HHS [R01AI110719, R56AI113313, R56 AI113313, R01 AI110719] Funding Source: Medline
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How dendritic cells (DCs) gather information from the local milieu at a site of infection or injury and communicate this to influence adaptive immunity is not well understood. We and others have reported that soon after microbial encounter, DCs secrete the p40 subunit of IL-12, by itself, in a monomeric form. Based on recent data that this p40 monomer subsequently associates with p35 released from other cells to generate functional IL-12, we proposed that p40 can function as a DC-derived probe which samples the composition of the local milieu by looking for other binding partners. In this opinion, we discuss how such a sampling function might generate an elaborate combinatorial code of heterodimeric cytokines, capable of conveying location-specific information to cells downstream of DC activation, including NK and T cells. (C) 2015 Elsevier Ltd. All rights reserved.
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