Review
Biochemistry & Molecular Biology
Nur Azizah A. Rahman, Vinod R. M. T. Balasubramaniam, Wei Boon Yap
Summary: The IL-12 family consists of cytokines that play a crucial role in activating host antiviral immunity and preventing excessive immune reactions. IL-12 and IL-23 stimulate T cell proliferation and effector cytokine release, leading to host defense against virus infections. IL-27 and IL-35 have dual functions in regulating cytokine synthesis, T cell proliferation, and viral antigen presentation to enhance virus clearance. The multitasking nature of the IL-12 family makes it a highly important target for antiviral therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Guoxing Tang, Min Huang, Ying Luo, Wei Liu, Qun Lin, Liyan Mao, Shiji Wu, Zhigang Xiong, Hongyan Hou, Ziyong Sun, Feng Wang
Summary: This study reveals that COVID-19 deceased patients exhibit immune dysregulation, including increased neutrophils and IL-6, sustained low levels of CD8(+) T cells, NK cells, and dendritic cells. Among the immunological parameters, M-MDSCs show the best performance in predicting COVID-19 mortality.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Rachael Y. M. Ryan, Jamie Seymour, Alex Loukas, J. Alejandro Lopez, Maria P. Ikonomopoulou, John J. Miles
Summary: This review explores the impact of venom on the human body, the effects of venom on the immune system, and venom-induced immunopathology. It examines in detail the immune pathology caused by venom, including allergies and systemic inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Sergey Ponomarev, Sergey Kalinin, Anastasiya Sadova, Marina Rykova, Kseniya Orlova, Brian Crucian
Summary: The exploration of outer space is crucial for national development and human civilization, but it can have negative effects on the immune system. Ground-based experiments are used to study the impact of confinement on immunity and develop strategies to counteract stress factors.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Fisheries
Wenjun Wang, Changliu Wang, Wei Chen, Shuo Ding
Summary: Amphioxus is an important animal model for studying the origin and evolution of vertebrate immunity, particularly the transition from innate immunity to adaptive immunity. Current research progress in immune organs, cells, complement system, cytokines, NF-κB, immune-related lectins and enzymes are summarized, with a focus on unresolved issues and the need for further clarification to lay a solid foundation for the construction of a three-dimensional immune network in amphioxus from ontogeny to phylogeny.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Hung Le, Paul Spearman, Stephen N. Waggoner, Karnail Singh
Summary: Accumulation of activated NK cells in tissues during Ebola virus infection contributes to EVD pathogenesis. Immunization with Ebola VLPs provides rapid, NK cell-mediated protection against Ebola challenge. VP40 protein stimulates NK cell functions in an IL-12- and IL-18-dependent manner involving CD14(+) and CD14(-) accessory cells.
Article
Multidisciplinary Sciences
Seon-Hee Kim, Eunjung Cho, Yu Kim, Chungyong Han, Beom K. Choi, Byoung S. Kwon
Summary: The study demonstrates that post-conditioning treatment with anti-CD4 can enhance the anti-tumor efficacy of adoptive T cell therapy (ACT) by promoting the expansion of IL-18R alpha(hi) CD8(+) T cells. This combination treatment accelerates proliferation and differentiation of tumor-reactive CD8(+) T cells and improves tumor suppression and host survival. The enrichment of polyfunctional IL-18R alpha(hi) CD8(+) T cells plays a key role in the induced tumor suppression, mediated by IL-18 signaling and TCR-MHC I interaction.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Fatemeh Ahmadi, Fredrik Junghus, Christian Ashworth, Amanda Lappalainen, Urs Morbe, Knut Kotarsky, William W. Agace
Summary: This study reveals that the post-weaning accumulation of Th1 cells in the intestine, which is microbiota-dependent, requires the expression of MHC-II and IL-27 by cDC1 cells. IL-27 derived from cDC1 cells plays a crucial role in maintaining the balance between Th1 and Th17 cells in the small intestinal lamina propria.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Review
Immunology
Takashi Mino, Osamu Takeuchi
Summary: Dynamic changes in gene expression are crucial for immune cell development and activation. RNA metabolism and specific RNases, such as endoribonuclease Regnase-1, play vital roles in controlling gene expression. Dysregulation of immune mRNA decay by RNases can lead to autoimmune diseases or impaired immune responses, making RNases potential targets for novel therapeutics in autoimmunity.
IMMUNOLOGICAL REVIEWS
(2021)
Review
Immunology
Jean M. Kanellopoulos, Cassio Luiz Coutinho Almeida-da-Silva, Sirje Ruutel Boudinot, David M. Ojcius
Summary: Extracellular nucleotides mediate activation through P2 and P1 receptors, with P2X4 receptor responding to ATP in lysosomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Carmen Picon, Amalia Tejeda-Velarde, Jose Ignacio Fernandez-Velasco, Manuel Comabella, Roberto Alvarez-Lafuente, Ester Quintana, Susana Sainz de la Maza, Enric Monreal, Noelia Villarrubia, Jose Carlos Alvarez-Cermeno, Maria Inmaculada Dominguez-Mozo, Lluis Ramio-Torrenta, Eulalia Rodriguez-Martin, Ernesto Roldan, Yolanda Aladro, Silvia Medina, Mercedes Espino, Jaime Masjuan, Clara Matute-Blanch, Marta Munoz-San Martin, Carmen Espejo, Carmen Guaza, Alfonso Muriel, Lucienne Costa-Frossard, Luisa Maria Villar
Summary: Patients with multiple sclerosis (MS) undergo an early immunosenescence process with age, impacting treatment response and infection risks. Lipid-specific oligoclonal IgM bands (LS-OCMB) in MS patients may modify the immunological profile influenced by age. Additionally, age leads to changes in CSF levels of various molecules and cellular subsets, affecting disability in MS patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Diana Boraschi
Summary: Interleukin-1 (IL-1) is a cytokine that plays a significant role in inflammation and immune response, primarily produced by macrophages during defensive reactions. It belongs to a superfamily of structurally similar proteins and acts through binding to specific receptors on the plasma membrane of target cells. IL-1 family cytokines not only have innate immune and inflammatory effects but also appear to be involved in the development of adaptive immunity in vertebrates.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Chiara Agostinis, Andrea Balduit, Alessandro Mangogna, Gabriella Zito, Federico Romano, Giuseppe Ricci, Uday Kishore, Roberta Bulla
Summary: Endometriosis is a chronic disease characterized by the presence and proliferation of endometrial tissues outside the uterus, with symptoms depending on the location of involvement. The risk of developing endometriosis is influenced by complex interactions between genetic, immunological, hormonal, and environmental factors.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Andrew D. Hildreth, Eddie T. Padilla, Meha Gupta, Yung Yu Wong, Ryan Sun, Akshara R. Legala, Timothy E. O'Sullivan
Summary: This study reveals that conventional type 1 dendritic cells (cDC1s) in white adipose tissue (WAT) take up DNA-containing apoptotic bodies from adipocytes, which triggers STING-dependent interleukin-12 production from cDC1s, contributing to WAT inflammation in mice.
Article
Critical Care Medicine
Daniel P. Cook, Christopher M. Thomas, Ashley Y. Wu, Mark Rusznak, Jian Zhang, Weisong Zhou, Jacqueline-Yvonne Cephus, Katherine N. Gibson-Corley, Vasiliy V. Polosukhin, Allison E. Norlander, Dawn C. Newcomb, David A. Stoltz, R. Stokes Peebles
Summary: Type 2 inflammation is observed in cystic fibrosis patients. This study reveals that CFTR deficiency leads to increased expression and release of IL-33, and deletion of IL-33 reduces allergen-induced inflammation in the CF lung.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Immunology
Eleanore Chuang, Marilyn Augustine, Matthew Jung, Ronald H. Schwartz, Nevil J. Singh
IMMUNOLOGY LETTERS
(2017)
Article
Immunology
Elizabeth M. Steinert, Ronald H. Schwartz, Nevil J. Singh
EUROPEAN JOURNAL OF IMMUNOLOGY
(2012)
Article
Immunology
Nevil J. Singh, Jennifer K. Bando, Ronald H. Schwartz
Article
Immunology
Kaveh Abdi, Nevil J. Singh, Polly Matzinger
JOURNAL OF IMMUNOLOGY
(2012)
Article
Immunology
Kaveh Abdi, Nevil J. Singh, Eric Spooner, Benedikt M. Kessler, Sergei Radaev, Larry Lantz, Tsan Sam Xiao, Polly Matzinger, Peter D. Sun, Hidde L. Ploegh
JOURNAL OF IMMUNOLOGY
(2014)
Article
Multidisciplinary Sciences
Kaveh Abdi, Tsute Chen, Brian A. Klein, Albert K. Tai, Jill Coursen, Xiangdong Liu, Jeff Skinner, Saravanan Periasamy, Youngnim Choi, Benedikt M. Kessler, Robert J. Palmer, Apostolos Gittis, Polly Matzinger, Margaret J. Duncan, Nevil J. Singh
Article
Immunology
Soyoung Oh, Ronald H. Schwartz, Nevil J. Singh
Article
Cell Biology
John Reiser, Kavitha Sadashivaiah, Aki Furusawa, Arnob Banerjee, Nevil Singh
CELLULAR IMMUNOLOGY
(2019)
Article
Immunology
Kenneth M. Rosenberg, Nevil J. Singh
BRAIN BEHAVIOR AND IMMUNITY
(2019)
Article
Multidisciplinary Sciences
Susannah C. Shissler, Nevil J. Singh, Tonya J. Webb
SCIENTIFIC REPORTS
(2020)
Review
Biochemistry & Molecular Biology
Courtney A. Matson, Nevil J. Singh
MOLECULAR IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Courtney A. Matson, Seeyoung Choi, Ferenc Livak, Bin Zhao, Apratim Mitra, Paul E. Love, Nevil J. Singh
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Review
Immunology
Zvi Grossman, Nevil J. Singh, Francesco R. Simonetti, Michael M. Lederman, Daniel C. Douek, Steven G. Deeks
TRENDS IN IMMUNOLOGY
(2020)
Article
Oncology
Sara Fioretti, Courtney A. Matson, Kenneth M. Rosenberg, Nevil J. Singh
Summary: Research shows that under CAR-T cell immunotherapy, normal B cells can downregulate the expression of CD19 to evade attack, and this downregulation is reversible. This finding is significant for improving immunotherapy and minimizing B cell depletion during treatment.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.
