Article
Biochemistry & Molecular Biology
Lenka Ceslova, Petra Kalendova, Lucie Dubnova, Marek Pernica, Jan Fischer
Summary: This study focuses on the analysis of anthocyanins in wild Czech elderberries using spectrophotometric methods and liquid chromatography. The results showed that frozen samples had higher antioxidant capacity and total phenolic and anthocyanin contents compared to dried samples, possibly due to the degradation of anthocyanins during the drying process.
Article
Food Science & Technology
Milena Terzic, Tatjana Majkic, Ivana Beara, Gokhan Zengin, Uros Miljic, Sasa Durovic, Adriano Mollica, Marija Radojkovic
Summary: In this study, the chemical and phytochemical composition, as well as the biological and pharmacological effects, of elderberry wine were investigated. The results showed that elderberry wine has strong antioxidant activity and enzyme inhibitory effects, indicating its high biological and industrial potential.
Article
Chemistry, Multidisciplinary
Angel Sanchez, Clara Miguez, Antia Iglesias, Lucia Saborido
Summary: Medicinal plants play a crucial role in sustainable economic development, the pharmaceutical industry, and biodiversity conservation. This study aimed to extract and analyze the potential uses of Sambucus nigra's flowers, leaves, and bark. Steam distillation and ethanol and glycerol extraction were employed, and the highest percentage of essential oil was found in the flowers. Ethanol showed better extraction efficiency compared to glycerol. The flower extracts had significant levels of total phenolic and total flavonoid content.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Multidisciplinary
Claudia M. B. Neves, Antonio Pinto, Fernando Goncalves, Dulcineia F. Wessel
Summary: Elderberry juice concentrate is rich in polyphenols, including anthocyanins and flavonols, which have various health-promoting properties. This study found that storage at room temperature led to a decline in anthocyanin content and an increase in polymeric color values. Storage at 5 degrees C had less impact on the contents of anthocyanins and chlorogenic acid. Overall, the antioxidant activity of elderberry concentrates remained stable over seven months of storage.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Applied
Milena Terzic, Tatjana Majkic, Gokhan Zengin, Ivana Beara, Carlos L. Cespedes-Acuna, Dejan Cavic, Marija Radojkovic
Summary: The results of this study suggest that lyophilization is a better drying technique than natural convection, and microwave extraction is the most efficient technique for isolating secondary metabolites. Phenolic compounds, particularly chlorogenic acid and rutin, were found in abundance in extracts of lyophilized elderberries. Elderberry extracts showed great antioxidant and enzyme inhibition potential. These findings highlight the potential use of elderberry as a natural source of bioactive compounds for the development of dietary supplements and functional foods.
Article
Chemistry, Multidisciplinary
Tiago Azevedo, Tiago Ferreira, Joao Ferreira, Filipa Teixeira, Diana Ferreira, Rita Silva-Reis, Maria Joao Neuparth, Maria Joao Pires, Maria de Lurdes Pinto, Rui M. Gil da Costa, Margarida M. S. M. Bastos, Rui Medeiros, Luis Felix, Carlos Venancio, Maria Ines Dias, Isabel Gaivao, Lillian Barros, Paula A. Oliveira
Summary: This study investigates the safety and efficacy of elderberry extract as a natural colorant, showing positive effects in mouse experiments and demonstrating potential for use in the food industry.
APPLIED SCIENCES-BASEL
(2022)
Article
Food Science & Technology
Min Liu, Jinxin Shen, Xiaoling Zhu, Tingting Ju, Benjamin P. Willing, Xin Wu, Qun Lu, Rui Liu
Summary: This study found that peanut skin procyanidins (PSP) improved glucose tolerance and insulin sensitivity in diabetic mice by decreasing the expression of glucose transporters in the intestines and altering various metabolic pathways in the serum.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Physiology
Ali Zahraei, George Guo, Kyriakos G. Varnava, Nicholas J. Demarais, Paul J. Donaldson, Angus C. Grey
Summary: This study spatially correlates the pattern of glucose uptake and glucose transporter distributions in cultured lenses, and maps glucose metabolism in different lens regions. It reveals the major uptake site of glucose in the bovine lens and the distribution and metabolism of glucose in different lens regions.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Nutrition & Dietetics
Colleen S. Deane, Ushnah S. U. Din, Tanvir S. Sian, Ken Smith, Amanda Gates, Jonathan N. Lund, John P. Williams, Ricardo Rueda, Suzette L. Pereira, Philip J. Atherton, Bethan E. Phillips
Summary: Acute curcumin supplementation enhances the effect of oral nutritional supplement on microvascular blood flow in healthy older adults, without affecting muscle glucose uptake, vascular function, or blood flow.
Article
Food Science & Technology
Camila Donoso-Barraza, Juan Carlos Borquez, Carlos Sepulveda, Francisco Diaz-Castro, Claudia Sepulveda-Quinenao, Juan Manuel Rodriguez, Omar Porras, Rodrigo Troncoso
Summary: This study investigates the role of hydrogen sulfide (H2S) in insulin signaling and glucose uptake. The results show that glucose restriction increases endogenous production of H2S and H2S disrupts insulin-induced glucose uptake, which may help maintain plasma glucose levels.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Endocrinology & Metabolism
Kohei Kido, Tatsuro Egawa, Shinya Watanabe, Kentaro Kawanaka, Jonas T. Treebak, Tatsuya Hayashi
Summary: This study demonstrated the synergistic enhancement of insulin-stimulated TBC1D4 phosphorylation and glucose uptake by fasting and prior muscle contraction, which is associated with augmented AMPK pathway activation.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Kazuki Watanabe, Sayaka Katagiri, Hirokazu Takahashi, Naoki Sasaki, Shogo Maekawa, Rina Komazaki, Masahiro Hatasa, Yoichiro Kitajima, Yusuke Maruyama, Takahiko Shiba, Keiji Komatsu, Yujin Ohsugi, Kenichi Tanaka, Ayumi Matsuzawa, Tomomitsu Hirota, Haruka Tohara, Yuichiro Eguchi, Keizo Anzai, Atsuhiko Hattori, Takanori Iwata
Summary: The study suggests that infection with Pg is a risk factor for metabolic syndrome and skeletal muscle metabolic dysfunction via gut microbiome alteration. Experimental results show that mice fed a high-fat diet and administered Pg displayed insulin resistance, impaired glucose tolerance, and fat infiltration in muscles, along with activation of the TNF-alpha signaling pathway in the soleus muscle.
Article
Chemistry, Analytical
Natalie J. Norman, Joyce Ghali, Tatiana L. Radzyukevich, Judith A. Heiny, Julio Landero-Figueroa
Summary: We developed a sensitive method using ICP-MS to simultaneously measure 13C-labeled glucose and rubidium in biological samples. The method extracts the analytes from mammalian tissues using probe-assisted ultra-sonication with water. The method achieves a stable 13C/12C signal without spectral interferences and can detect 60μM of 13C-labeled glucose in biological tissues.
MICROCHEMICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Ayumi Goto, Yuki Endo, Hitoshi Yamashita
Summary: The study investigates the role of CREG1 in skeletal muscle regeneration and glucose uptake. Results show that CREG1 stimulates glucose uptake in skeletal muscles partially through AMPK activation. This suggests that CREG1 plays an essential role in muscle regeneration by affecting glucose metabolism in skeletal muscles.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Shui-Yuan Feng, Shu-Jing Wu, Yun-Ching Chang, Lean-Teik Ng, Sue-Joan Chang
Summary: Anthocyanin-rich extracts from black rice stimulate GLUT4 glucose uptake via upregulation of PI3K/Akt and AMPK/p38 MAPK signaling, suggesting their potential as functional food in the prevention and treatment of insulin resistance and diabetic hyperglycemia.
Article
Plant Sciences
Gopalakrishnan Saroja Seethapathy, Kaliamoorthy Ravikumar, Bent Smestad Paulsen, Hugo J. de Boer, Helle Wangensteen
JOURNAL OF ETHNOPHARMACOLOGY
(2018)
Article
Sport Sciences
Jose L. Areta, Ingvild Austarheim, Helle Wangensteen, Carlo Capelli
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2018)
Letter
Sport Sciences
Jose L. Areta, Ingvild Austarheim, Helle Wangensteen, Carlo Capelli
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2018)
Article
Multidisciplinary Sciences
Gopalakrishnan Saroja Seethapathy, Margey Tadesse, Santhosh Kumar J. Urumarudappa, Srikanth V. Gunaga, Ramesh Vasudeva, Karl Egil Malterud, Ramanan Uma Shaanker, Hugo J. de Boer, Gudasalamani Ravikanth, Helle Wangensteen
SCIENTIFIC REPORTS
(2018)
Article
Plant Sciences
Gopalakrishnan Saroja Seethapathy, Ancuta-Cristina Raclariu-Manolica, Jarl Andreas Anmarkrud, Helle Wangensteen, Hugo J. de Boer
FRONTIERS IN PLANT SCIENCE
(2019)
Article
Plant Sciences
Christopher Dean Goodman, An Thuy Hoang, Drissa Diallo, Karl Egil Malterud, Geoffrey I. McFadden, Helle Wangensteen
Article
Biochemistry & Molecular Biology
Oleksandr Shulha, Serhat Sezai Cicek, Helle Wangensteen, Janina Kroes, Malte Maeder, Ulrich Girreser, Jandirk Sendker, Karin Joehrer, Richard Greil, Wolfgang Schuehly, Alfonso Mangoni, Laura Grauso, Christoph van Thriel, Christian Zidorn
Article
Food Science & Technology
Christian W. Wold, William H. Gerwick, Helle Wangensteen, Kari T. Inngjerdingen
JOURNAL OF FUNCTIONAL FOODS
(2020)
Article
Chemistry, Medicinal
Gopalakrishnan Saroja Seethapathy, Christian Winther Wold, Kaliamoorthy Ravikumar, Hugo J. de Boer, Helle Wangensteen
Summary: The resin of Canarium strictum Roxb. is used for treating colds, respiratory diseases, and rheumatoid arthritis; while the bark contains procyanidins and sugars as major constituents. The study found that resin and bark extracts have antioxidant and anti-inflammatory effects, and are non-toxic to Artemia salina nauplii.
Review
Plant Sciences
Yu-Ping Fu, Yuan-Feng Zou, Fei-Yi Lei, Helle Wangensteen, Kari Tvete Inngjerdingen
Summary: This article provides a systematic overview of the phytochemical and pharmacological studies of Aconitum carmichaelii, focusing on polysaccharides and phenolic compounds. Polysaccharides from A. carmichaelii roots have shown various biological effects and have potential for future applications. More research is needed to better understand the pharmacological effects and molecular mechanisms of the identified phenolic compounds.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Emilie Steinbakk Ulriksen, Hussain Shakeel Butt, Ane Ohrvik, Rebecca Angelica Blakeney, Anneleen Kool, Helle Wangensteen, Marit Inngjerdingen, Kari Tvete Inngjerdingen
Summary: This study aims to explore the usage of medicinal plants in Scandinavian folk medicine and to discover potential new sources of immunomodulatory compounds by screening water extracts from previously overlooked medicinal plants. The results identify 10 species with immune activating effects and 8 species with immune inhibitory effects. The study provides a comprehensive overview of Scandinavian medicinal plants and supports the combination of historical sources and modern pharmacology to discover new plant sources with potential pharmacological compounds.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Yu-Ping Fu, Cen-Yu Li, Xi Peng, Helle Wangensteen, Kari Tvete Inngjerdingen, Yuan- Feng Zou
Summary: The study found that the acidic polysaccharide fraction AL-I extracted from the unused leaves of Aconitum carmichaelii has a protective effect on ulcerative colitis. It can alleviate symptoms and colonic pathological injury, improve inflammatory indices, and restore the production of short- and branched-chain fatty acids. The protective effect is believed to be due to the inhibition of NOD1 and TLR4 activation, the promotion of tight-junction protein gene transcription, and the modulation of gut microbiota composition.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Applied
Yu-Ping Fu, Cen-Yu Li, Xi Peng, Yuan-Feng Zou, Frode Rise, Berit Smestad Paulsen, Helle Wangensteen, Kari Tvete Inngjerdingen
Summary: This study investigated the polysaccharides in the unutilized leaves of Aconitum carmichaelii. It was found that a neutral polysaccharide was a mixture of hetemmannans, and two acidic polysaccharides were pectins containing a homogalacturonan backbone. These polysaccharides were able to modulate the complement system and had anti-inflammatory effects.
CARBOHYDRATE POLYMERS
(2022)
Article
Food Science & Technology
Nastaran Moussavi, Hasina Azizullah, Karl E. Malterud, Kari T. Inngjerdingen, Helle Wangensteen
Summary: This study explores the anti-inflammatory effects of Sideritis scardica in vitro, with a focus on neurodegenerative disease. The results demonstrate the broad-spectrum activity of this herb, which might potentially serve as a multi-target system in Alzheimer's disease.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Plant Sciences
Lin Zhang, Emilie Steinbakk Ulriksen, Havard Hoel, Lene Sandvik, Karl Egil Malterud, Kari Tvete Inngjerdingen, Marit Inngjerdingen, Helle Wangensteen
Summary: This study aimed to explore the content of bioactive compounds in the water extract of Gentiana purpurea roots, commonly used in traditional medicine in Norway, and assess its anti-inflammatory potential. The major bitter compounds in both roots and leaves were also quantified.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)