Reversing the Amyloid Trend: Mechanism of Fibril Assembly and Dissolution of the Repeat Domain from a Human Functional Amyloid

Alzheimer's Disease and the Amyloid-β Peptide

(2017) M. Paul Murphy et al.   JOURNAL OF ALZHEIMERS DISEASE

Identification of an amyloid fibril forming segment of human Pmel17 repeat domain (RPT domain)

(2016) Nikolaos N. Louros et al.   BIOPOLYMERS

Dynamic Assembly and Disassembly of Functional β-Endorphin Amyloid Fibrils

(2016) Nadezhda Nespovitaya et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular Basis of Orb2 Amyloidogenesis and Blockade of Memory Consolidation

(2016) Rubén Hervás et al.   PLOS BIOLOGY

Amyloid Polymorphism: Structural Basis and Neurobiological Relevance

(2015) Robert Tycko   NEURON

Molecular Origin of pH-Dependent Fibril Formation of a Functional Amyloid

(2014) Ryan P. McGlinchey et al.   CHEMBIOCHEM

Lysophospholipid-Containing Membranes Modulate the Fibril Formation of the Repeat Domain of a Human Functional Amyloid, Pmel17

(2014) Zhiping Jiang et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

(2013) Jun-Xia Lu et al.   CELL

Critical residues in the PMEL/Pmel17 N-terminus direct the hierarchical assembly of melanosomal fibrils

(2013) Ralf M. Leonhardt et al.   MOLECULAR BIOLOGY OF THE CELL

The PKD domain distinguishes the trafficking and amyloidogenic properties of the pigment cell protein PMEL and its homologue GPNMB

(2013) Alexander C. Theos et al.   Pigment Cell & Melanoma Research

Critical Role of Amyloid-like Oligomers of Drosophila Orb2 in the Persistence of Memory

(2012) Amitabha Majumdar et al.   CELL

Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

(2012) Masato Kato et al.   CELL

Oligomeric Intermediates in Amyloid Formation: Structure Determination and Mechanisms of Toxicity

(2012) Marcus Fändrich   JOURNAL OF MOLECULAR BIOLOGY

Antiparallel  -sheet architecture in Iowa-mutant  -amyloid fibrils

(2012) W. Qiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Probing Fibril Dissolution of the Repeat Domain of a Functional Amyloid, Pmel17, on the Microscopic and Residue Level

(2011) Ryan P. McGlinchey et al.   BIOCHEMISTRY

Segmental Polymorphism in a Functional Amyloid

(2011) Kan-Nian Hu et al.   BIOPHYSICAL JOURNAL

Proprotein Convertases Process Pmel17 during Secretion

(2011) Ralf M. Leonhardt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Insights into Functional and Pathological Amyloid

(2011) Frank Shewmaker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The yin and yang of amyloid: insights from α-synuclein and repeat domain of Pmel17

(2011) Ryan P. McGlinchey et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Inactivation of Pmel Alters Melanosome Shape But Has Only a Subtle Effect on Visible Pigmentation

(2011) Anders R. Hellström et al.   PLoS Genetics

Repeat Domains of Melanosome Matrix Protein Pmel17 Orthologs Form Amyloid Fibrils at the Acidic Melanosomal pH

(2010) Ryan P. McGlinchey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoplasmic Reticulum Export, Subcellular Distribution, and Fibril Formation by Pmel17 Require an Intact N-terminal Domain Junction

(2010) Ralf M. Leonhardt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Huntington's disease: from molecular pathogenesis to clinical treatment

(2010) Christopher A Ross et al.   LANCET NEUROLOGY

Prions

(2010) Anja Böckmann et al.   Prion

Effects of pH on aggregation kinetics of the repeat domain of a functional amyloid, Pmel17

(2010) C. M. Pfefferkorn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biology of Amyloid: Structure, Function, and Regulation

(2010) Jason Greenwald et al.   STRUCTURE

Evidence for Novel β-Sheet Structures in Iowa Mutant β-Amyloid Fibrils

(2009) Robert Tycko et al.   BIOCHEMISTRY

N-terminal Domains Elicit Formation of Functional Pmel17 Amyloid Fibrils

(2009) Brenda Watt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Functional Curli Amyloid Is Not Based on In-register Parallel β-Sheet Structure

(2009) Frank Shewmaker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular mechanisms for protein-encoded inheritance

(2009) Jed J W Wiltzius et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The repeat domain of the melanosome fibril protein Pmel17 forms the amyloid core promoting melanin synthesis

(2009) R. P. McGlinchey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Seeded growth of  -amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure

(2009) A. K. Paravastu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Measurement of amyloid fibril mass-per-length by tilted-beam transmission electron microscopy

(2009) B. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules

(2009) S. K. Maji et al.   SCIENCE

Structural Classification of Toxic Amyloid Oligomers

(2008) Charles G. Glabe   JOURNAL OF BIOLOGICAL CHEMISTRY

Electron tomography of early melanosomes: Implications for melanogenesis and the generation of fibrillar amyloid sheets

(2008) I. Hurbain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular structural basis for polymorphism in Alzheimer's  -amyloid fibrils

(2008) A. K. Paravastu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibrils with parallel in-register structure constitute a major class of amyloid fibrils: molecular insights from electron paramagnetic resonance spectroscopy

(2008) Martin Margittai et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Amyloid Fibrils of the HET-s(218-289) Prion Form a   Solenoid with a Triangular Hydrophobic Core

(2008) C. Wasmer et al.   SCIENCE