Focused ultrasound for immuno-adjuvant treatment of pancreatic cancer: An emerging clinical paradigm in the era of personalized oncotherapy

Release of Cell-free MicroRNA Tumor Biomarkers into the Blood Circulation with Pulsed Focused Ultrasound: A Noninvasive, Anatomically Localized, Molecular Liquid Biopsy

(2017) John R. Chevillet et al.   RADIOLOGY

Transfer of Allogeneic CD4 + T Cells Rescues CD8 + T Cells in Anti-PD-L1–Resistant Tumors Leading to Tumor Eradication

(2017) Ainhoa Arina et al.   Cancer Immunology Research

Combined sonodynamic and antimetabolite therapy for the improved treatment of pancreatic cancer using oxygen loaded microbubbles as a delivery vehicle

(2016) Conor McEwan et al.   BIOMATERIALS

Interstitial Pressure in Pancreatic Ductal Adenocarcinoma Is Dominated by a Gel-Fluid Phase

(2016) Christopher C. DuFort et al.   BIOPHYSICAL JOURNAL

Phase Ib Study of PEGylated Recombinant Human Hyaluronidase and Gemcitabine in Patients with Advanced Pancreatic Cancer

(2016) S. R. Hingorani et al.   CLINICAL CANCER RESEARCH

High-intensity focused ultrasound (HIFU) for pancreatic carcinoma: evaluation of feasibility, reduction of tumour volume and pain intensity

(2016) Milka Marinova et al.   EUROPEAN RADIOLOGY

Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma

(2016) Avery D. Posey et al.   IMMUNITY

Immunotherapy for pancreatic cancer

(2016) Elias Kotteas et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer

(2016) Georg Dimcevski et al.   JOURNAL OF CONTROLLED RELEASE

Therapeutic Effects of Microbubbles Added to Combined High-Intensity Focused Ultrasound and Chemotherapy in a Pancreatic Cancer Xenograft Model

(2016) Mi Hye Yu et al.   KOREAN JOURNAL OF RADIOLOGY

Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer

(2016) S Chouaib et al.   ONCOGENE

Immunotherapy of non-Hodgkin’s lymphoma with a defined ratio of CD8 + and CD4 + CD19-specific chimeric antigen receptor–modified T cells

(2016) Cameron J. Turtle et al.   Science Translational Medicine

Transformation of the tumour microenvironment by a CD40 agonist antibody correlates with improved responses to PD-L1 blockade in a mouse orthotopic pancreatic tumour model

(2016) Nadia M. Luheshi et al.   Oncotarget

Immunotherapy in pancreatic cancer treatment: a new frontier

(2016) Komal Thind et al.   Therapeutic Advances in Gastroenterology

Hypoxia: a key player in antitumor immune response. A Review in the Theme: Cellular Responses to Hypoxia

(2015) Muhammad Zaeem Noman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

T Cells Engineered against a Native Antigen Can Surmount Immunologic and Physical Barriers to Treat Pancreatic Ductal Adenocarcinoma

(2015) Ingunn M. Stromnes et al.   CANCER CELL

Endogenous T-Cell Therapy

(2015) Cassian Yee et al.   CANCER JOURNAL

Pulsed High-Intensity Focused Ultrasound Enhances Delivery of Doxorubicin in a Preclinical Model of Pancreatic Cancer

(2015) Tong Li et al.   CANCER RESEARCH

Effects of extracellular pH and hypoxia on the function and development of antigen-specific cytotoxic T lymphocytes

(2015) Yohko Nakagawa et al.   IMMUNOLOGY LETTERS

Specific antitumour immunity of HIFU-activated cytotoxic T lymphocytes after adoptive transfusion in tumour-bearing mice

(2015) Li-Feng Ran et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Histotripsy methods in mechanical disintegration of tissue: Towards clinical applications

(2015) Vera A. Khokhlova et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Safety and Survival With GVAX Pancreas Prime and Listeria Monocytogenes–Expressing Mesothelin (CRS-207) Boost Vaccines for Metastatic Pancreatic Cancer

(2015) Dung T. Le et al.   JOURNAL OF CLINICAL ONCOLOGY

Chemotherapy-Refractory Diffuse Large B-Cell Lymphoma and Indolent B-Cell Malignancies Can Be Effectively Treated With Autologous T Cells Expressing an Anti-CD19 Chimeric Antigen Receptor

(2015) James N. Kochenderfer et al.   JOURNAL OF CLINICAL ONCOLOGY

Oxygen carrying microbubbles for enhanced sonodynamic therapy of hypoxic tumours

(2015) Conor McEwan et al.   JOURNAL OF CONTROLLED RELEASE

T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

(2015) Daniel W Lee et al.   LANCET

Hypoxia-mediated immune evasion of pancreatic carcinoma cells

(2015) YEBIN LU et al.   Molecular Medicine Reports

Cyclooxygenase-2 or Tumor Necrosis Factor-α Inhibitors Attenuate the Mechanotransductive Effects of Pulsed Focused Ultrasound to Suppress Mesenchymal Stromal Cell Homing to Healthy and Dystrophic Muscle

(2015) Pamela A. Tebebi et al.   STEM CELLS

Stimulation of dendritic cells by DAMPs in ALA-PDT treated SCC tumor cells

(2015) Xiaojie Wang et al.   Oncotarget

Induction of T-cell Immunity Overcomes Complete Resistance to PD-1 and CTLA-4 Blockade and Improves Survival in Pancreatic Carcinoma

(2015) R. Winograd et al.   Cancer Immunology Research

Regulatory T cells that co-express RORγt and FOXP3 are pro-inflammatory and immunosuppressive and expand in human pancreatic cancer

(2015) Stalin Chellappa et al.   OncoImmunology

Cancer-Stellate Cell Interactions Perpetuate the Hypoxia-Fibrosis Cycle in Pancreatic Ductal Adenocarcinoma

(2015) Mert Erkan et al.   NEOPLASIA

Ultrasound induced cancer immunotherapy

(2014) Johan Unga et al.   ADVANCED DRUG DELIVERY REVIEWS

Systematic review of innovative ablative therapies for the treatment of locally advanced pancreatic cancer

(2014) S. J. E. Rombouts et al.   BRITISH JOURNAL OF SURGERY

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

(2014) L. Rahib et al.   CANCER RESEARCH

Targeted depletion of an MDSC subset unmasks pancreatic ductal adenocarcinoma to adaptive immunity

(2014) Ingunn M Stromnes et al.   GUT

Emerging HIFU applications in cancer therapy

(2014) Ezekiel Maloney et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Carcinoembryonic Antigen-Specific but Not Antiviral CD4+ T Cell Immunity Is Impaired in Pancreatic Carcinoma Patients

(2014) E. Tassi et al.   JOURNAL OF IMMUNOLOGY

Dynamic expression of transcription factors T-bet and GATA-3 by regulatory T cells maintains immunotolerance

(2014) Fang Yu et al.   NATURE IMMUNOLOGY

Upregulation of autophagy by hypoxia-inducible factor-1α promotes EMT and metastatic ability of CD133+ pancreatic cancer stem-like cells during intermittent hypoxia

(2014) HAITAO ZHU et al.   ONCOLOGY REPORTS

An Increased Abundance of Tumor-Infiltrating Regulatory T Cells Is Correlated with the Progression and Prognosis of Pancreatic Ductal Adenocarcinoma

(2014) Yichen Tang et al.   PLoS One

Pancreatic Ductal Adenocarcinoma Contains an Effector and Regulatory Immune Cell Infiltrate that Is Altered by Multimodal Neoadjuvant Treatment

(2014) Kendall C. Shibuya et al.   PLoS One

Ultrasound-guided tissue fractionation by high intensity focused ultrasound in an in vivo porcine liver model

(2014) T. D. Khokhlova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Luciferase Activity under the Control of an hsp70 Promoter Using High-Intensity Focused Ultrasound: Combination of Bioluminescence and MRI Imaging in Three Different Tumour Models

(2014) W. Hundt et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

Passive Cavitation Detection during Pulsed HIFU Exposures of Ex Vivo Tissues and In Vivo Mouse Pancreatic Tumors

(2014) Tong Li et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Systematic review of novel ablative methods in locally advanced pancreatic cancer

(2014) Margaret G Keane   WORLD JOURNAL OF GASTROENTEROLOGY

Immunotherapy Converts Nonimmunogenic Pancreatic Tumors into Immunogenic Foci of Immune Regulation

(2014) E. R. Lutz et al.   Cancer Immunology Research

Role of the Hypoxia-inducible factor-1 alpha induced autophagy in the conversion of non-stem pancreatic cancer cells into CD133+ pancreatic cancer stem-like cells

(2013) Haitao Zhu et al.   Cancer Cell International

A Mechanism of Hypoxia-Mediated Escape from Adaptive Immunity in Cancer Cells

(2013) I. B. Barsoum et al.   CANCER RESEARCH

Evaluation of Ipilimumab in Combination With Allogeneic Pancreatic Tumor Cells Transfected With a GM-CSF Gene in Previously Treated Pancreatic Cancer

(2013) Dung T. Le et al.   JOURNAL OF IMMUNOTHERAPY

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Mutational heterogeneity in cancer and the search for new cancer-associated genes

(2013) Michael S. Lawrence et al.   NATURE

The immune network in pancreatic cancer development and progression

(2013) S M Wörmann et al.   ONCOGENE

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

(2013) C. Feig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Noninvasive pulsed focused ultrasound allows spatiotemporal control of targeted homing for multiple stem cell types in murine skeletal muscle and the magnitude of cell homing can be increased through repeated applications

(2013) Scott R. Burks et al.   STEM CELLS

Pulsed High-Intensity Focused Ultrasound Enhances Apoptosis of Pancreatic Cancer Xenograft with Gemcitabine

(2013) Eun Sun Lee et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Histological and Biochemical Analysis of Mechanical and Thermal Bioeffects in Boiling Histotripsy Lesions Induced by High Intensity Focused Ultrasound

(2013) Yak-Nam Wang et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer

(2012) Lauren J. Bayne et al.   CANCER CELL

Oncogenic Kras-Induced GM-CSF Production Promotes the Development of Pancreatic Neoplasia

(2012) Yuliya Pylayeva-Gupta et al.   CANCER CELL

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

(2012) Michael A Jacobetz et al.   GUT

High-intensity focused ultrasound treatment for patients with unresectable pancreatic cancer

(2012) Peng-Zhou Li et al.   Hepatobiliary & Pancreatic Diseases International

The role of antigen-specific and non-specific immunotherapy in the treatment of cancer

(2012) Arta M. Monjazeb et al.   Journal of Immunotoxicology

Low-pressure pulsed focused ultrasound with microbubbles promotes an anticancer immunological response

(2012) Hao-Li Liu et al.   Journal of Translational Medicine

HMGB1 and leukocyte migration during trauma and sterile inflammation

(2012) Emilie Venereau et al.   MOLECULAR IMMUNOLOGY

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

(2012) Andrew V. Biankin et al.   NATURE

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ultrasonic atomization of tissue and its role in tissue fractionation by high intensity focused ultrasound

(2012) Julianna C Simon et al.   PHYSICS IN MEDICINE AND BIOLOGY

M-HIFU Inhibits Tumor Growth, Suppresses STAT3 Activity and Enhances Tumor Specific Immunity in a Transplant Tumor Model of Prostate Cancer

(2012) Xiaoyi Huang et al.   PLoS One

High-Intensity Focused Ultrasound Tumor Ablation Activates Autologous Tumor-Specific Cytotoxic T Lymphocytes

(2012) Ji-Zhu Xia et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias

(2011) R. J. Brentjens et al.   BLOOD

Hypoxia Predicts Aggressive Growth and Spontaneous Metastasis Formation from Orthotopically Grown Primary Xenografts of Human Pancreatic Cancer

(2011) Q. Chang et al.   CANCER RESEARCH

A Live-Attenuated Listeria Vaccine (ANZ-100) and a Live-Attenuated Listeria Vaccine Expressing Mesothelin (CRS-207) for Advanced Cancers: Phase I Studies of Safety and Immune Induction

(2011) D. T. Le et al.   CLINICAL CANCER RESEARCH

Sonoporation Delivery of Interleukin-27 Gene Therapy Efficiently Reduces Prostate Tumor Cell Growth In Vivo

(2011) Olga Zolochevska et al.   HUMAN GENE THERAPY

Analgesic effect of high intensity focused ultrasound therapy for unresectable pancreatic cancer

(2011) Kun Wang et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice

(2011) Elizabeth A. Wohlfert et al.   JOURNAL OF CLINICAL INVESTIGATION

Prophylactic immunization with Bubble liposomes and ultrasound-treated dendritic cells provided a four-fold decrease in the frequency of melanoma lung metastasis

(2011) Yusuke Oda et al.   JOURNAL OF CONTROLLED RELEASE

Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer

(2011) Lucia De Monte et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Proteomic Analysis Reveals Warburg Effect and Anomalous Metabolism of Glutamine in Pancreatic Cancer Cells

(2011) Weidong Zhou et al.   JOURNAL OF PROTEOME RESEARCH

Controlled tissue emulsification produced by high intensity focused ultrasound shock waves and millisecond boiling

(2011) Tatiana D. Khokhlova et al.   JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA

Cavitation clouds created by shock scattering from bubbles during histotripsy

(2011) Adam D. Maxwell et al.   JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA

Suppression of Melanoma Growth and Metastasis by DNA Vaccination Using an Ultrasound-Responsive and Mannose-Modified Gene Carrier

(2011) Keita Un et al.   MOLECULAR PHARMACEUTICS

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia

(2011) David L. Porter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Long-Term Outcome of High-Intensity Focused Ultrasound in Advanced Pancreatic Cancer

(2011) Hye Young Sung et al.   PANCREAS

Circulating CD4+CD25+ Regulatory T Cells in Patients With Pancreatic Cancer

(2011) Tomohisa Yamamoto et al.   PANCREAS

Hypoxia Induces Tumor Aggressiveness and the Expansion of CD133-Positive Cells in a Hypoxia-Inducible Factor-1α-Dependent Manner in Pancreatic Cancer Cells

(2011) Okito Hashimoto et al.   PATHOBIOLOGY

Investigation of Cellular and Molecular Responses to Pulsed Focused Ultrasound in a Mouse Model

(2011) Scott R. Burks et al.   PLoS One

CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

(2011) G. L. Beatty et al.   SCIENCE

High-Intensity Focused Ultrasound Ablation: Effective and Safe Therapy for Solid Tumors in Difficult Locations

(2010) Franco Orsi et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Concurrent gemcitabine and high-intensity focused ultrasound therapy in patients with locally advanced pancreatic cancer

(2010) Hong Zhao et al.   ANTI-CANCER DRUGS

Development of an ultrasound-responsive and mannose-modified gene carrier for DNA vaccine therapy

(2010) Keita Un et al.   BIOMATERIALS

Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19

(2010) J. N. Kochenderfer et al.   BLOOD

Tumour necrosis is a postoperative prognostic marker for pancreatic cancer patients with a high interobserver reproducibility in histological evaluation

(2010) N Hiraoka et al.   BRITISH JOURNAL OF CANCER

Hypoxia-inducible proto-oncogene Pim-1 is a prognostic marker in pancreatic ductal adenocarcinoma

(2010) Carolin Reiser-Erkan et al.   CANCER BIOLOGY & THERAPY

Anti-inflammatory Triterpenoid Blocks Immune Suppressive Function of MDSCs and Improves Immune Response in Cancer

(2010) S. Nagaraj et al.   CLINICAL CANCER RESEARCH

Phase 2 Trial of Single Agent Ipilimumab (Anti-CTLA-4) for Locally Advanced or Metastatic Pancreatic Adenocarcinoma

(2010) Richard E. Royal et al.   JOURNAL OF IMMUNOTHERAPY

Distant metastasis occurs late during the genetic evolution of pancreatic cancer

(2010) Shinichi Yachida et al.   NATURE

Enhancement of antitumor vaccine in ablated hepatocellular carcinoma by high-intensity focused ultrasound

(2010) Ying Zhang   WORLD JOURNAL OF GASTROENTEROLOGY

Cancer gene therapy by IL-12 gene delivery using liposomal bubbles and tumoral ultrasound exposure

(2009) Ryo Suzuki et al.   JOURNAL OF CONTROLLED RELEASE

The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects

(2009) D. L. Schwartz et al.   MOLECULAR CANCER THERAPEUTICS

Shock-Induced Heating and Millisecond Boiling in Gels and Tissue Due to High Intensity Focused Ultrasound

(2009) Michael S. Canney et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Ultrasound mediated delivery of drugs and genes to solid tumors

(2008) Victor Frenkel   ADVANCED DRUG DELIVERY REVIEWS

The effect of high intensity focused ultrasound treatment on metastases in a murine melanoma model

(2008) Yifei Xing et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Allogeneic Granulocyte Macrophage Colony-Stimulating Factor-Secreting Tumor Immunotherapy Alone or in Sequence with Cyclophosphamide for Metastatic Pancreatic Cancer: A Pilot Study of Safety, Feasibility, and Immune Activation

(2008) D. Laheru et al.   CLINICAL CANCER RESEARCH

A novel strategy utilizing ultrasound for antigen delivery in dendritic cell-based cancer immunotherapy

(2008) Ryo Suzuki et al.   JOURNAL OF CONTROLLED RELEASE