Article
Oncology
Ying Du, Gang Geng, Chunquan Zhao, Tian Gao, Bin Wei
Summary: The study found that MEG3 plays a regulatory role in cervical cancer, promoting sensitivity to cisplatin in CC cells through the miR-21/PTEN axis.
Article
Oncology
Weiwei Yang, Xiaoyan Wang, Shujie Song, Yongli Chu, Dengjun Sun, Xiang Yu, Yanfen Zou
Summary: This study comprehensively analyzed the expression pattern of lncRNAs in cervical cancer and evaluated their correlation with patient survival. Aberrant expression of hundreds of lncRNAs associated with cervical cancer was identified, and some of them were significantly associated with poor patient prognosis. ALOX12-AS1, in particular, was found to play a critical role in cervical cancer progression.
Article
Cell Biology
Shengbai Sun, Chaoqun Li, Kaisa Cui, Bingxin Liu, Mingyue Zhou, Yulin Cao, Jia Zhang, Zehua Bian, Bojian Fei, Zhaohui Huang
Summary: The circular RNA circ_0062682 promotes serine metabolism and tumor growth in colorectal cancer by regulating the miR-940/PHGDH axis, suggesting it as a potential novel therapeutic target for CRC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Lei Dou, Yi Zhang
Summary: miR-4461 plays a significant role in ovarian cancer by promoting cancer cell proliferation and metastasis while inhibiting PTEN; the impact of miR-4461 silenced cells on PTEN can be partially alleviated by si-PTEN; cisplatin has a pronounced effect on miR-4461 silenced cells.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, Research & Experimental
Hongxiang Li, Yin Li, Dongmei Tian, Jiaqian Zhang, Shiwei Duan
Summary: miR-940, located on chromosome 16p13.3, exhibits expression imbalance in various diseases and plays a crucial role in regulating cellular processes and cancer development pathways. Its expression is closely associated with the diagnosis, prognosis, and efficacy of chemotherapy drugs in tumor patients.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Oncology
Jiaqi Wang, Yuhki Yokoyama, Haruka Hirose, Yuki Shimomura, Saki Bonkobara, Hiroaki Itakura, Shihori Kouda, Yoshihiro Morimoto, Kazumasa Minami, Hidekazu Takahashi, Satoshi Shibata, Shogo Kobayashi, Mamoru Uemura, Susumu Tanaka, Xin Wu, Shinji Tanaka, Masaki Mori, Hirofumi Yamamoto
Summary: miR-1291 exerts an anti-tumor effect in colorectal cancer cells by suppressing proliferation, invasion, cell mobility, and colony formation, inducing cell apoptosis, inhibiting cancer stemness, and regulating cell cycle through the modulation of multiple genes and proteins such as DCLK1, BMI1, CD133, p21, and p27.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Anatomy & Morphology
Kun Guo, Jialiang Wang, Ling Shu, Guangjun Zhou
Summary: This study revealed that miR-200c is upregulated in human PTC tissues and associated with poor clinical prognosis. Overexpression of miR-200c promotes PTC cell proliferation, migration, and invasion while knockdown has an inhibitory effect. PTEN is identified as a downstream target of miR-200c, playing a crucial role in promoting PTC progression. Targeting the miR-200c/PTEN axis may have therapeutic significance in PTC patients.
Article
Medicine, General & Internal
Wenting Li, Bo Yang, Yiqun Li, Cuicui Wang, Xinzhi Fang
Summary: The expression of miR-141 and miR-340 in cervical squamous cell carcinoma (CSCC) is associated with clinicopathological features and may be involved in the carcinogenesis of cervical squamous epithelium.
Article
Biotechnology & Applied Microbiology
Qin Zhu, Xian Zhang, Hong-Yan Zai, Wei Jiang, Ke-Jing Zhang, Yu-Qiong He, Yu Hu
Summary: The study suggests that circSLC8A1 plays a role in breast cancer by regulating the miR-671 and PTEN/PI3k/Akt signaling pathways, leading to inhibition of tumor growth and metastasis.
Article
Pathology
Feng Huang, Yuan Xiang, Ting Li, You Huang, Jun Wang, Hui-Min Zhang, Han-Han Li, Zhou-Tong Dai, Jia-Peng Li, Hui Li, Jun Zhou, Xing-Hua Liao
Summary: Metformin has been found to inhibit proliferation and induce apoptosis in gastric cancer cells by modulating the AMPK signaling pathway. Additionally, it synergistically promotes cancer cell apoptosis with miR-365 through the miR-365-PTEN-AMPK axis. This study reveals a novel signaling pathway in gastric cancer regulation and highlights the potential therapeutic application of metformin in the future.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Medicine, Research & Experimental
Dan-Dan Yuan, Cun-De Jia, Ming-Yu Yan, Jian Wang
Summary: The study revealed that circ_0000730 is significantly down-regulated in cervical cancer (CC) and associated with shorter survival time of patients. It can inhibit the proliferation, migration, and invasion of CC cells through regulating the miR-942-5p/PTEN axis. Circ_0000730 may act as a tumor suppressor in CC and could be a potential target for CC treatment.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Oncology
Jia Yang, Zhiling Yan, Yingying Wang, Jinmei Xu, Rui Li, Chuanyin Li, Shuyuan Liu, Li Shi, Yufeng Yao
Summary: Our study suggests that rs2297538 and rs2297537 in miR-126, rs1292037 and rs13137 in miR-21, and rs2745709 in miR-221/222 may play important roles in the development of CIN or CC.
Article
Oncology
Jie Zhang, Gulimire Buranjiang, Zuohelaguli Mutalifu, Hua Jin, Liyan Yao
Summary: This study found that KIF14 plays a role in promoting cell proliferation, migration, and invasion in cervical cancer, and causes cell cycle arrest by inhibiting p27 degradation. These findings provide a new therapeutic target for cervical cancer.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Zhijia Jiang, Xiaomeng Song, Yaqing Wei, Yanxun Li, Degang Kong, Jinjin Sun
Summary: This study revealed the role of miR-380-3p in regulating pancreatic cancer progression through m6A modification and PTEN/Akt pathway. Overexpression of miR-380-3p promoted cell proliferation, epithelial-mesenchymal transition, and tumorigenesis, while knockdown of miR-380-3p had the opposite effects. Furthermore, miR-380-3p targeted PTEN to activate the downstream Akt signal pathway. This study provides important insights into the treatment and diagnosis of pancreatic cancer.
Article
Genetics & Heredity
Wei Wang, Lu Liu, Yongjian Tian
Summary: microRNA miR-19-3p regulates the proliferation, invasion, and autophagy of cervical cancer cells. Overexpression of miR-19-3p reduces apoptosis and autophagy while promoting cell proliferation and invasion. These findings suggest that miR-19-3p could be a potential target for cervical cancer treatment in the future.