What have human experimental overfeeding studies taught us about adipose tissue expansion and susceptibility to obesity and metabolic complications?

Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease

(2016) Hanieh Yaghootkar et al.   DIABETES

Adipose Cell Size and Regional Fat Deposition as Predictors of Metabolic Response to Overfeeding in Insulin-Resistant and Insulin-Sensitive Humans

(2016) Tracey McLaughlin et al.   DIABETES

Adipose tissue transcriptomics and epigenomics in low birthweight men and controls: role of high-fat overfeeding

(2016) Linn Gillberg et al.   DIABETOLOGIA

Effect of Three Levels of Dietary Protein on Metabolic Phenotype of Healthy Individuals With 8 Weeks of Overfeeding

(2016) George A. Bray et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Normal-Weight Central Obesity: Implications for Total and Cardiovascular Mortality

(2015) Karine R. Sahakyan et al.   ANNALS OF INTERNAL MEDICINE

Normal weight individuals who develop Type 2 diabetes: the personal fat threshold

(2015) Roy Taylor et al.   CLINICAL SCIENCE

Short-term high-fat diet increases macrophage markers in skeletal muscle accompanied by impaired insulin signalling in healthy male subjects

(2015) Mariëtte R. Boon et al.   CLINICAL SCIENCE

Metabolically healthy and unhealthy obesity: differential effects on myocardial function according to metabolic syndrome, rather than obesity

(2015) R Dobson et al.   INTERNATIONAL JOURNAL OF OBESITY

The cell biology of fat expansion

(2015) Joseph M. Rutkowski et al.   JOURNAL OF CELL BIOLOGY

Metabolically normal obese people are protected from adverse effects following weight gain

(2015) Elisa Fabbrini et al.   JOURNAL OF CLINICAL INVESTIGATION

New genetic loci link adipose and insulin biology to body fat distribution

(2015) Dmitry Shungin et al.   NATURE

The flavonoid, naringenin, decreases adipose tissue mass and attenuates ovariectomy-associated metabolic disturbances in mice

(2015) Jia-Yu Ke et al.   Nutrition & Metabolism

Potential link between excess added sugar intake and ectopic fat: a systematic review of randomized controlled trials

(2015) Jiantao Ma et al.   NUTRITION REVIEWS

Effect of Fructose on Established Lipid Targets: A Systematic Review and Meta‐Analysis of Controlled Feeding Trials

(2015) Laura Chiavaroli et al.   Journal of the American Heart Association

Effects of weight gain induced by controlled overfeeding on physical activity

(2014) John W. Apolzan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Metabolic profile before and after short-term overfeeding with a high-fat diet: a comparison between South Asian and white men

(2014) Siti N. Wulan et al.   BRITISH JOURNAL OF NUTRITION

Genetic Evidence for a Normal-Weight "Metabolically Obese" Phenotype Linking Insulin Resistance, Hypertension, Coronary Artery Disease, and Type 2 Diabetes

(2014) H. Yaghootkar et al.   DIABETES

Overfeeding Polyunsaturated and Saturated Fat Causes Distinct Effects on Liver and Visceral Fat Accumulation in Humans

(2014) F. Rosqvist et al.   DIABETES

Distinct Developmental Profile of Lower-Body Adipose Tissue Defines Resistance Against Obesity-Associated Metabolic Complications

(2014) Katherine E. Pinnick et al.   DIABETES

Effect of 8 Weeks of Overfeeding on Ectopic Fat Deposition and Insulin Sensitivity: Testing the “Adipose Tissue Expandability” Hypothesis

(2014) Darcy L. Johannsen et al.   DIABETES CARE

Ethnic-Specific Obesity Cutoffs for Diabetes Risk: Cross-sectional Study of 490,288 UK Biobank Participants

(2014) Uduakobong E. Ntuk et al.   DIABETES CARE

Ethnicity-specific obesity cut-points in the development of Type 2 diabetes - a prospective study including three ethnic groups in the United Kingdom

(2014) T. Tillin et al.   DIABETIC MEDICINE

Effect of fructose on markers of non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of controlled feeding trials

(2014) S Chiu et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Hypercaloric diets with increased meal frequency, but not meal size, increase intrahepatic triglycerides: A randomized controlled trial

(2014) Karin E. Koopman et al.   HEPATOLOGY

Regulation of Energy Metabolism and Mitochondrial Function in Skeletal Muscle During Lipid Overfeeding in Healthy Men

(2014) K. Seyssel et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Weight Gain Reveals Dramatic Increases in Skeletal Muscle Extracellular Matrix Remodeling

(2014) Charmaine S. Tam et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Biology of upper-body and lower-body adipose tissue—link to whole-body phenotypes

(2014) Fredrik Karpe et al.   Nature Reviews Endocrinology

Specific appetite, energetic and metabolomics responses to fat overfeeding in resistant-to-bodyweight-gain constitutional thinness

(2014) N Germain et al.   Nutrition & Diabetes

Visceral Fat Accumulation During Lipid Overfeeding Is Related to Subcutaneous Adipose Tissue Characteristics in Healthy Men

(2013) Maud Alligier et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Exercise counteracts the effects of short-term overfeeding and reduced physical activity independent of energy imbalance in healthy young men

(2013) Jean-Philippe Walhin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Circulating glucagon-like peptide-1 increases in response to short-term overfeeding in men

(2013) Danny Wadden et al.   Nutrition & Metabolism

Effects of fructose and glucose overfeeding on hepatic insulin sensitivity and intrahepatic lipids in healthy humans

(2013) V. Lecoultre et al.   Obesity

Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans

(2012) Ksenia Sevastianova et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Modeling Metabolic Adaptations and Energy Regulation in Humans

(2012) Kevin D. Hall   Annual Review of Nutrition

Effect of Dietary Protein Content on Weight Gain, Energy Expenditure, and Body Composition During Overeating

(2012) George A. Bray et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Changes in insulin sensitivity precede changes in body composition during 14 days of step reduction combined with overfeeding in healthy young men

(2012) Sine Haugaard Knudsen et al.   JOURNAL OF APPLIED PHYSIOLOGY

Metabolically Healthy Obesity and Risk of All-Cause and Cardiovascular Disease Mortality

(2012) Mark Hamer et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Serum Acylated Ghrelin Concentrations in Response to Short-Term Overfeeding in Normal Weight, Overweight, and Obese Men

(2012) Danny Wadden et al.   PLoS One

Serum peptide YY in response to short-term overfeeding in young men

(2011) Farrell Cahill et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Subcutaneous Adipose Tissue Remodeling during the Initial Phase of Weight Gain Induced by Overfeeding in Humans

(2011) M. Alligier et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Quantification of the effect of energy imbalance on bodyweight

(2011) Kevin D Hall et al.   LANCET

Long-Term Persistence of Hormonal Adaptations to Weight Loss

(2011) Priya Sumithran et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects of short-term overfeeding with fructose, fat and fructose plus fat on plasma and hepatic lipids in healthy men

(2010) H. Sobrecases et al.   DIABETES & METABOLISM

A family history of type 2 diabetes increases risk factors associated with overfeeding

(2010) D. Samocha-Bonet et al.   DIABETOLOGIA

Insulin Sensitivity and Regional Fat Gain in Response to Overfeeding

(2010) Susanne B. Votruba et al.   Obesity

Regional differences in cellular mechanisms of adipose tissue gain with overfeeding

(2010) Y. D. Tchoukalova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of the Fibrosis and Angiogenesis Promoter SPARC/Osteonectin in Human Adipose Tissue by Weight Change, Leptin, Insulin, and Glucose

(2009) K. Kos et al.   DIABETES

Energy metabolism, fuel selection and body weight regulation

(2009) J Galgani et al.   INTERNATIONAL JOURNAL OF OBESITY

Ethnic Variation in Fat and Lean Body Mass and the Association with Insulin Resistance

(2009) Scott A. Lear et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Effects of Overfeeding on the Neuronal Response to Visual Food Cues in Thin and Reduced-Obese Individuals

(2009) Marc-Andre Cornier et al.   PLoS One

Identification and Characterization of Metabolically Benign Obesity in Humans

(2008) Norbert Stefan   ARCHIVES OF INTERNAL MEDICINE

Effects of Short-Term High-Fat, High-Energy Diet on Hepatic and Myocardial Triglyceride Content in Healthy Men

(2008) Rutger W. van der Meer et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM