Article
Chemistry, Multidisciplinary
Sophie Morse, Aishwarya Mishra, Tiffany G. Chan, Rafael T. M. de Rosales, James J. Choi
Summary: The study investigates a noninvasive method of using ultrasound pulses to deliver liposomes across the blood-brain barrier for efficient drug delivery to the brain.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Acoustics
Marieke Olsman, Viktoria Sereti, Melina Muhlenpfordt, Kasper Bendix Johnsen, Thomas Lars Andresen, Andrew James Urquhart, Catharina De Lange Davies
Summary: Research shows that combining FUS and microbubbles with BBB-targeting liposomes can enhance drug delivery to the brain. Transferrin receptor-targeting liposomes exhibited increased accumulation in the FUS-treated hemisphere, while isotype immunoglobulin G liposomes did not show significant increase.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Ko-Ting Chen, Kuo-Chen Wei, Hao-Li Liu
Summary: Focused ultrasound combined with microbubbles enables precise, transient, reversible, and noninvasive opening of the blood-brain barrier. This technology enhances the penetration of therapeutic agents in the central nervous system, while also modulating local immunity and neuronal activity.
Article
Multidisciplinary Sciences
Pavlos Anastasiadis, Dheeraj Gandhi, Yutong Guo, Abdul-Kareem Ahmed, Soren M. Bentzen, Costas Arvanitis, Graeme F. Woodworth
Summary: This study evaluates the safety and utility of microbubble-enhanced focused ultrasound for spatially targeted blood-brain barrier opening in patients with infiltrating gliomas.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, Research & Experimental
Charissa Poon, Carly Pellow, Kullervo Hynynen
Summary: The study demonstrates that transcranial focused ultrasound with microbubbles treatments can induce acute inflammatory responses involving neutrophils, though multiple treatments do not significantly increase neutrophil recruitment or phagocytosis of beta-amyloid plaques in an Alzheimer's disease mouse model. Further investigations into leukocyte dynamics and cerebral blood flow responses to these treatments are needed.
Article
Engineering, Biomedical
Maria Eleni Karakatsani, Antonios N. Pouliopoulos, Michael Liu, Sachin R. Jambawalikar, Elisa E. Konofagou
Summary: The study investigated the use of diffusion tensor imaging for detecting focused ultrasound-induced blood-brain barrier opening, showing an increase in fractional anisotropy and diffusion anisotropy enhancement post-BBB opening. The experiment confirmed the feasibility of the technique and suggested its potential as a contrast-free MRI modality for evaluating BBB integrity in brain-related pathologies.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Review
Engineering, Biomedical
Paul Mondou, Sebastien Meriaux, Florent Nageotte, Jonathan Vappou, Anthony Novell, Benoit Larrat
Summary: This review summarizes the current state of in vitro and in vivo cavitation control algorithms for blood-brain barrier (BBB) permeabilization using microbubbles (MB) and focused ultrasound (FUS). It describes the different cavitation states, the indexes used for ultrasonic monitoring, and the various control strategies for BBB permeabilization.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Engineering, Biomedical
Oliver Vince, Sarah Peeters, Vanessa A. Johanssen, Michael Gray, Sean Smart, Nicola R. Sibson, Eleanor Stride
Summary: The study shows that a new formulation of microbubbles containing lysolipids can enhance blood-brain barrier permeability, leading to approximately twofold increase at the highest ultrasound pressure. This modification has the potential to improve drug delivery deep within the brain without the need to increase ultrasound pressure amplitude.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Pharmacology & Pharmacy
Scott Schoen, M. Sait Kilinc, Hohyun Lee, Yutong Guo, F. Levent Degertekin, Graeme F. Woodworth, Costas Arvanitis
Summary: Brain tumors located in the central nervous system (CNS) present a unique challenge due to limited drug access to the brain tumor microenvironment (TME). Recent advancements in microbubble ultrasound contrast agents and ultrasound energy have shown promise in enhancing drug delivery to brain tumors. This technology has the potential to improve the effectiveness of both traditional chemotherapy and novel immunotherapeutic agents. Early clinical studies have demonstrated safety, and ongoing Phase I/II trials are testing the preclinical findings.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
E. 't Hart, J. Bianco, M. A. C. Bruin, M. Derieppe, H. C. Besse, K. Berkhout, L. A. Chin Joe Kie, Y. Su, E. W. Hoving, A. D. R. Huitema, M. G. Ries, D. G. van Vuurden
Summary: Diffuse midline glioma H3K27-altered (DMG) is a pediatric brain tumor with limited treatment options and poor prognosis. This study evaluated the potential of PARP1 inhibition combined with focused ultrasound mediated blood-brain barrier opening (FUS-BBBO) to enhance radiosensitivity in DMG.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Multidisciplinary Sciences
Carmen Gasca-Salas, Beatriz Fernandez-Rodriguez, Jose A. Pineda-Pardo, Rafael Rodriguez-Rojas, Ignacio Obeso, Frida Hernandez-Fernandez, Marta del Alamo, David Mata, Pasqualina Guida, Carlos Ordas-Bandera, J. Ignacio Montero-Roblas, Raul Martinez-Fernandez, Guglielmo Foffani, Itay Rachmilevitch, Jose A. Obeso
Summary: MRgFUS-BBB opening in PDD is safe, reversible, and can be performed repeatedly. This study provides encouragement for the concept of BBB opening for drug delivery to treat dementia in PD and other neurodegenerative disorders.
NATURE COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Yu-Hone Hsu, Wei-Chung Lee, Shing-Shung Chu, Meng-En Chao, Kuo-Sheng Wu, Ren-Shyan Liu, Tai-Tong Wong
Summary: Pulsed ultrasound combined with microbubbles can temporarily disrupt the blood-brain barrier (BBB) and open a temporal window for delivering large therapeutic molecules into brain tissue. This study investigates the effects of different sonication parameters, time, and microbubble dose on BBB disruption, as well as the dynamics of BBB disruption and the efficacy of different sonication schemes. The results show that pulsed weakly focused ultrasound can extensively and reversibly open the BBB with limited brain tissue damage.
Article
Chemistry, Multidisciplinary
Dallan McMahon, Lulu Deng, Kullervo Hynynen
Summary: The study compared the safety and efficacy of drug delivery to the brain using 10 ms tone bursts and rapid short-pulse (RaSP) sequence with transcranial focused ultrasound and microbubble exposure. The RaSP sequence did not show measurable improvements over the B10 sequence in terms of blood-brain barrier permeability enhancement for drug delivery, and may present an increased risk of vascular damage.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Marie-Solenne Felix, Emilie Borloz, Khaled Metwally, Ambre Dauba, Benoit Larrat, Valerie Matagne, Yann Ehinger, Laurent Villard, Anthony Novell, Serge Mensah, Jean-Christophe Roux
Summary: Gene therapy is a powerful tool for treating diseased tissues and providing lasting and effective correction. The combination of focused ultrasound and microbubbles appears to be a technological breakthrough for delivering therapeutic agents to the central nervous system.
Article
Biotechnology & Applied Microbiology
Chuanshi He, Zhisheng Wu, Min Zhuang, Xiangyu Li, Shunxu Xue, Songjie Xu, Jinshun Xu, Zhe Wu, Man Lu
Summary: In this study, bionic drug delivery microbubbles were developed and their combination with focused ultrasound showed significant inhibitory effects on glioblastoma. The microbubbles successfully penetrated the blood-brain barrier and effectively inhibited glioblastoma growth, providing a new approach for glioblastoma treatment.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Ching-Hsiang Fan, Yi-Ju Ho, Chia-Wei Lin, Nan Wu, Pei-Hua Chiang, Chih-Kuang Yeh
Summary: In this article, the authors summarized recent progress on US-responsible drug carriers, focusing on the routes of enhancing delivery and applications. They discussed three specific mechanisms that enhance in vivo drug delivery via US with US-responsible carriers and reviewed the state-of-the-art materials for US-triggered drug delivery.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Medicine, Research & Experimental
Pei-Hua Chiang, Ching-Hsiang Fan, Qiaofeng Jin, Chih-Kuang Yeh
Summary: By coating the surface of ADS NPs with a superhydrophobic layer and modifying it with a phospholipid layer, it is possible to overcome the challenge of insufficient drug dose in chemotherapy. The release of drugs can be triggered by ultrasound, enhancing the fluorescence intensity in the tumor region.
MOLECULAR PHARMACEUTICS
(2022)
Article
Engineering, Biomedical
Haoming Lin, Tiemei Chen, Dingqian Deng, Zhaoke Pi, Siyuan Xie, Ge Ding, Tingting Qi, Kaixin Shu, Xiangwei Lin, Zhourui Xu, Zhiyong Wang, Siping Chen, Mian Chen, Xin Chen
Summary: This study proposes a method of magnetomotive ultrasound shear wave elastography (MMUS-SWE) that utilizes magnetic nanoparticles and an external magnetic field to generate shear waves for the detection of tissue elasticity. The results show that the distribution of the nanoparticles and the elastic information of surrounding tissues can be simultaneously detected, indicating potential applications for disease diagnosis.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Haoming Lin, Yi Chen, LinGuo Yu, Siyuan Xie, Tong Sun, Mengmeng Yu, Siping Chen, Mian Chen, Xin Chen
Summary: Magneto-acoustic-electric computed tomography (MAE-CT) is proposed as an improved implementation of MAET based on multi-angle plane wave excitation. The method combines electronic steering with mechanical rotation to increase the number of projection angles and improve both SNR and spatial resolution. Feasibility is verified through simulation and experimental studies.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Computer Science, Artificial Intelligence
Tong Sun, Linguo Yu, Dingqian Deng, Mengmeng Yu, Yi Chen, Chunqi Chang, Mian Chen, Siping Chen, Xin Chen, Haoming Lin
Summary: Magneto-acousto-electrical tomography (MAET) is a hybrid imaging modality that combines high contrast and high resolution. Current studies mainly focus on two-dimensional imaging, but the conductivity of objects is usually three-dimensional inhomogeneous. This study investigates the feasibility of three-dimensional MAET based on a one-dimensional ultrasound transducer and coded-excitation technology. Experimental results show that this method can accurately reflect the conductivity distribution in three-dimensional space. Rating: 8 points.
Article
Chemistry, Analytical
Xiangwei Lin, Hongji Shi, Zhenyu Fu, Haoming Lin, Siping Chen, Xin Chen, Mian Chen
Summary: To improve the imaging quality of ultrasound computed tomography (USCT), this study utilizes a dynamic speed of sound (SoS) map to correct for acoustic speed variation in the reflection USCT. The variable SoS map is restored using an optimized algebraic reconstruction technique and the delay time from each element to the imaging field of view is calculated using a multi-stencils fast marching method. The proposed method enables multi-modality imaging, accurate target localization, and precise boundary detection with fast imaging performance, making it valuable for accurate, fast, and multi-modality USCT imaging in highly acoustic heterogeneous medium.
Article
Acoustics
Ching-Hsiang Fan, Nan Wu, Chih-Kuang Yeh
Summary: Sonodynamic therapy using carbon dots microbubbles as sonosensitizers with ultrasound irradiation effectively induced lipid peroxidation, intracellular ROS elevation, and apoptosis in cancer cells, suggesting its potential as a novel strategy for tumor therapy.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Acoustics
Yaxin Hu, Jianpeng Wei, Yuanyuan Shen, Siping Chen, Xin Chen
Summary: Emerging evidence has shown that cavitation creates bidirectional channels for drug delivery and biomarker release. This study reviews recent advancements in ultrasound and contrast agents, as well as details the cellular responses and vascular effects of cavitation. The article also highlights the current achievements in using cavitation for drug delivery and biomarker release, while acknowledging the challenges of precise induction and proposes methods for in-situ cavitation imaging and feedback control for clinical guidance.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Computer Science, Information Systems
Zhong Liu, Bin Huang, Huiying Wen, Zhicheng Lu, Qicai Huang, Meiqin Jiang, Changfeng Dong, Yingxia Liu, Xin Chen, Haoming Lin
Summary: This article proposes a handcrafted-feature-assisted deep convolutional neural network (HFA-DCNN) for the automatic and accurate diagnosis of significant liver fibrosis in patients with chronic liver disease (CLD). The model achieves high accuracy and area under the receiver-operating-characteristic curve (AUC) values, making it a promising tool for the noninvasive diagnosis of significant liver fibrosis in CLD patients.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Correction
Radiology, Nuclear Medicine & Medical Imaging
Zhong Liu, Wei Li, Ziqi Zhu, Huiying Wen, Ming-de Li, Chao Hou, Hui Shen, Bin Huang, Yudi Luo, Wei Wang, Xin Chen
EUROPEAN RADIOLOGY
(2023)
Article
Cell & Tissue Engineering
Thi-Nhan Phan, Ching-Hsiang Fan, Chih-Kuang Yeh
Summary: Pluripotent stem cell therapy is an important regenerative approach for treating diseases, but it faces challenges such as low cell transplantation efficiency and uncontrollable differentiation. Ultrasound (US) has shown potential in enhancing stem cell therapy by promoting proliferation, differentiation, migration, and in vivo detection of stem cells. Combining US with US-responsive particles can provide enhanced physical-chemical stimulation and drug delivery. In-depth evaluation of the role and mechanism of US in stem cell therapy can improve understanding and encourage further research in this field.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhong Liu, Wei Li, Ziqi Zhu, Huiying Wen, Ming-de Li, Chao Hou, Hui Shen, Bin Huang, Yudi Luo, Wei Wang, Xin Chen
Summary: This study developed a deep learning model that integrates ultrasound contrast-enhanced micro-flow (CEMF) cines, B-mode images, and clinical parameters to improve the diagnosis of significant liver fibrosis (>= F2) in patients with chronic hepatitis B (CHB).
EUROPEAN RADIOLOGY
(2023)
Article
Acoustics
Yuanchao Shi, Weixiong Weng, Mengting Chen, Haoqiang Huang, Xin Chen, Yin Peng, Yaxin Hu
Summary: As a non-viral transfection method, sonoporation can achieve spatially targeted gene delivery with synergistic immunostimulatory effects. By optimizing the sonoporation protocol, we successfully improved the transfection efficiency and achieved a record-breaking 400 days of gene expression, confirming the potential of sonoporation as an efficient and safe DNA vaccination method.
ULTRASONICS SONOCHEMISTRY
(2023)
Proceedings Paper
Acoustics
Yingtao Liao, Xin Chen, Siping Chen, Haoming Lin, Yuanyuan Shen
Summary: Using ultrasound localization microscopy (ULM), this study found that AD mice exhibit abnormal cerebral vasculature, including lower vascular density, more tortuous penetrating arterioles, and reduced cortical volumetric blood flow.
2022 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS)
(2022)
Proceedings Paper
Acoustics
Mengni Hu, Lu Xia, Xin Chen, Siping Chen, Yuanyuan Shen
Summary: The study visualized the effect of FUS/MB on cerebral vessels in vivo using two-photon fluorescence microscopy, and found that FUS/MB treatment caused endothelial cell defects and suggested an alternative pathway for BBB opening.
2022 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS)
(2022)