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Biochemistry & Molecular Biology
Sadeeshkumar Velayutham, Ryan Seerattan, Maab Sultan, Trisha Seal, Samaya Danthurthy, Baskaran Chinnappan, Jessica Landi, Kaitlyn Pearl, Aveta Singh, Keiran S. M. Smalley, Julia Zaias, Jun Yong Choi, Dmitriy Minond
Summary: This study demonstrates the potential therapeutic efficacy of targeting spliceosomal proteins hnRNPH1 and H2 in reducing the growth of melanoma.
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Biology
Marius-Alexandru Beleaua, Ioan Jung, Cornelia Braicu, Doina Milutin, Simona Gurzu
Summary: The study investigated the diagnostic and prognostic utility of conventional pan-melanoma cocktail members in malignant melanoma, in combination with SOX10 and SOX11 immunohistochemical expression. SOX11 positivity was directly correlated with clinicopathological factors, while the conventional pan-melanoma cocktail successfully differentiated benign nevi from melanomas.
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Multidisciplinary Sciences
Michael Hamm, Pierre Sohier, Valerie Petit, Jeremy H. Raymond, Veronique Delmas, Madeleine Le Coz, Franck Gesbert, Colin Kenny, Zackie Aktary, Marie Pouteaux, Florian Rambow, Alain Sarasin, Nisamanee Charoenchon, Alfonso Bellacosa, Luis Sanchez-del-Campo, Laura Mosteo, Martin Lauss, Dies Meijer, Eirikur Steingrimsson, Goran B. Jonsson, Robert A. Cornell, Irwin Davidson, Colin R. Goding, Lionel Larue
Summary: BRN2 is a key transcription factor that regulates melanoma invasion, but its role in melanoma initiation was previously unclear. This study shows that BRN2 acts as a haplo-insufficient tumor suppressor that positively regulates PTEN expression, and in the context of BRAF mutation and heterozygous PTEN, loss of BRN2 promotes melanoma initiation and progression.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Haoyao Sun, Kritisha Bhandari, Stephanie Burrola, Jinchang Wu, Wei-Qun Ding
Summary: Chemo-resistance poses challenges in the clinical management of pancreatic ductal adenocarcinoma (PDAC). Limited drug uptake by PDAC tissues is a major barrier in chemotherapy for this malignancy. Small extracellular vesicles (sEVs) have shown potential as drug carriers for targeted delivery to tumor cells due to their low immunogenicity and affinity towards tumors. This study evaluated sEVs derived from different human cell lines as carriers for paclitaxel (PTX) and found that incubation with HPNE-derived sEVs led to the most effective killing of PDAC cells. The uptake of PTX-loaded sEVs was mediated via clathrin-dependent endocytosis. These results suggest that EVs derived from hTERT-HPNE cells are effective drug carriers to enhance the efficacy of paclitaxel in PDAC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Audun Kvalvaag, Salvatore Valvo, Pablo F. Cespedes, David G. Saliba, Elke Kurz, Kseniya Korobchevskaya, Michael L. Dustin
Summary: Ligation of TCR to pMHC induces TCR ubiquitination and either internalization by T cell or release in extracellular vesicles. Clathrin-mediated ectocytosis facilitates the release of TCR, while clathrin-mediated trans-endocytosis enables the uptake of pMHC-TCR conjugates from the APC.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Biochemistry & Molecular Biology
Anja Wessely, Theresa Steeb, Carola Berking, Markus Vincent Heppt
Summary: Early detection is crucial for the prognosis of cutaneous melanoma, and new therapies have significantly improved patient survival. The aggressiveness of melanoma is closely related to the embryonic origin of melanocytes and melanoma cells, as well as cellular plasticity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Adriana Sanna, Bengt Phung, Shamik Mitra, Martin Lauss, Jiyeon Choi, Tongwu Zhang, Ching-Ni Njauw, Eugenia Cordero, Katja Harbst, Frida Rosengren, Rita Cabrita, Iva Johansson, Karolin Isaksson, Christian Ingvar, Ana Carneiro, Kevin Brown, Hensin Tsao, My Andersson, Kristian Pietras, Goran Jonsson
Summary: Cellular stress contributes to the phenotype switching of melanoma cells, and this is associated with the loss of specific gene expression and increased expression of mesenchymal markers. The loss of microphthalmia-associated transcription factor (MITF) and SRY-box transcription factor 10 (SOX10) is related to this process, and their loss is associated with promoter hypermethylation and poor patient survival.
Article
Oncology
Kenta Sasaki, Yoshihiko Hirohashi, Kenji Murata, Tomoyuki Minowa, Munehide Nakatsugawa, Aiko Murai, Yuka Mizue, Terufumi Kubo, Takayuki Kanaseki, Tomohide Tsukahara, Sadahiro Iwabuchi, Shinichi Hashimoto, Hisashi Uhara, Akemi Ishida-yamamoto, Toshihiko Torigoe
Summary: This study investigates the relationship between SOX10 and the immune checkpoint molecule PD-L1 in malignant melanoma. The results demonstrate that overexpression of SOX10 increases PD-L1 expression, while knockdown of SOX10 decreases its expression. The study concludes that SOX10 has a role in the intrinsic immune suppressive mechanisms of melanoma through the expression of PD-L1.
ANTICANCER RESEARCH
(2023)
Article
Plant Sciences
Claudio Osorio-Navarro, Jorge Toledo, Lorena Norambuena
Summary: Sucrose induces cell elongation and endocytosis in plant roots, and its regulation is reversible. The endocytosis mediated by sucrose is dependent on clathrin-mediated mechanism and plays a role in sensing energy status and signaling root elongation.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biology
Tania Lopez-Hernandez, Koh-Ichiro Takenaka, Yasunori Mori, Pornparn Kongpracha, Shushi Nagamori, Volker Haucke, Shigeo Takamori
Summary: This study found that the endocytosis of synaptic vesicles in mouse hippocampal neurons at physiological temperature is independent of clathrin, while the endocytic retrieval of certain synaptic vesicle proteins, including vesicular transporters for glutamate and GABA, relies on sorting by the clathrin adaptor AP-2.
Article
Oncology
Husvinee Sundaramurthi, Sandra Garcia-Mulero, Valentina Tonelotto, Kayleigh Slater, Simone Marcone, Josep M. Piulats, Ronald William Watson, Desmond J. Tobin, Lasse D. Jensen, Breandan N. Kennedy
Summary: The drug ACY-1215 has been found to inhibit the growth of primary ocular uveal melanoma (UM) cells and UM cells that have spread to the liver, offering potential as a treatment for advanced UM.
Article
Biochemistry & Molecular Biology
Zheng Wu, Chengyu Fan, Yi Man, Yue Zhang, Ruili Li, Xiaojuan Li, Yanping Jing
Summary: The study demonstrated that clathrin-mediated endocytosis and membrane microdomain-associated endocytosis are both involved in the adaptation to hyperosmotic stress in plant cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Benjamin Barsi-Rhyne, Aashish Manglik, Mark von Zastrow
Summary: Beta-arrestins are important regulators of cellular signaling, involving in the desensitization and endocytosis of GPCRs. Two different modes of endocytic activity have been discovered, one dependent on the C-terminus and the other dependent on the C-lobe of beta-arrestins. These modes are triggered in a receptor-specific manner and have opposite effects on the signaling output of receptors.
Article
Plant Sciences
Lihui Jiang, Baolin Yao, Xiaoyan Zhang, Lixia Wu, Qijing Fu, Yiting Zhao, Yuxin Cao, Ruomeng Zhu, Xinqi Lu, Wuying Huang, Jianping Zhao, Kuixiu Li, Shuanglu Zhao, Li Han, Xuan Zhou, Chongyu Luo, Haiyan Zhu, Jing Yang, Huichuan Huang, Zhengge Zhu, Xiahong He, Jiri Friml, Zhongkai Zhang, Changning Liu, Yunlong Du
Summary: Salicylic acid inhibits rice root growth by interfering with auxin transport through OsPIN3t-mediated mutation and clathrin-mediated endocytosis, which is different from TyrA23-mediated root growth.
Article
Biochemistry & Molecular Biology
Yutong Wang, Xu Yan, Mei Xu, Weiyang Qi, Chunjie Shi, Xiaohong Li, Jiaqi Ma, Dan Tian, Jianxin Shou, Haijun Wu, Jianwei Pan, Bo Li, Chao Wang
Summary: Clathrin-mediated endocytosis (CME) is a major endocytic pathway in eukaryotic cells that regulates the abundance of plasma membrane proteins. The phytohormone auxin differentially regulates the clathrin heavy chains (CHCs) and light chains (CLCs), as well as the distribution of the auxin efflux transporter PIN2. The involvement of transmembrane kinase (TMKs) family proteins, specifically TMK1, in the regulation of clathrin and CME by auxin has been discovered, highlighting their critical role in establishing an asymmetric distribution of PIN2 and an auxin gradient during root gravitropism.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Ye Wang, Qi-Wei Yang, Qing Yang, Tie Zhou, Min-Feng Shi, Chen-Xia Sun, Xiu-Xia Gao, Yan-Qiong Cheng, Xin-Gang Cui, Ying-Hao Sun
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2017)
Article
Oncology
Leilei Xia, Ye Wang, Ya Chen, Jiuqiong Yan, Fan Hao, Xiaoling Su, Caihong Zhang, Mingjuan Xu
Article
Cell Biology
Y. Wang, F. Yang, H-X Zhang, X-Y Zi, X-H Pan, F. Chen, W-D Luo, J-X Li, H-Y Zhu, Y-P Hu
CELL DEATH & DISEASE
(2013)
Article
Engineering, Environmental
Leilei Xia, Caihong Zhang, Dan Li, Lihua Yang, Wei Sun, Shengyun Cai, Qi Meng, Jizi Shen, Ye Wang, Mingjuan Xu
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2019)
Article
Immunology
Leilei Xia, Ye Wang, Shengyun Cai, Mingjuan Xu
Summary: The study suggests that DGAT1 expression is associated with the clinical phenotype of ovarian cancer, with poor prognosis in patients with high expression. Inhibiting DGAT1 expression can effectively suppress the proliferation, migration, and invasion of tumor cells, potentially involving in immune processes.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Engineering, Biomedical
Qiwei Yang, Ye Wang, Qing Yang, Yi Gao, Xiaopeng Duan, Qingcheng Fu, Chuanmin Chu, Xiuwu Pan, Xingang Cui, Yinghao Sun
Article
Oncology
Zhengyu Jiang, Hongxia Zhang, Ye Wang, Bin Yu, Chen Wang, Changcheng Liu, Juan Lu, Fei Chen, Minjun Wang, Xinlu Yu, Jiahao Lin, Xinghua Pan, Pin Wang, Haiying Zhu
Article
Nanoscience & Nanotechnology
Ye Wang, Xiao-Yuan Zi, Juan Su, Hong-Xia Zhang, Xin-Rong Zhang, Hai-Ying Zhu, Jian-Xiu Li, Meng Yin, Feng Yang, Yi-Ping Hu
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2012)