Journal
ONCOTARGET
Volume 8, Issue 37, Pages 61083-61092Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.17854
Keywords
cuprous oxide nanoparticle; cervical cancer; nanomedicine; therapy; AKT/mTOR pathway
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Cervical carcinoma is one of the main causes of women's cancer, and substantial side effects from standard treatment including platinum-based chemotherapy limit the options for escalation. In this paper, using cervical cancer cell lines and tumor-bearing mice as models, we report that CONPs could inhibit the proliferation of cancer cells in vitro and in vivo. Especially CONPs could inhibit tumor growth as cisplatin without weight loss. CONPs could also induce autophagy through AKT/mTOR pathway, which demonstrates that CONPs has the potential clinical applications.
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