Review
Engineering, Biomedical
Muyue Yang, Jipeng Li, Ping Gu, Xianqun Fan
Summary: The development and metastasis of tumors are closely linked to the tumor microenvironment (TME). Nanoparticles, with their unique physical properties and design, show potential in efficiently penetrating TME and delivering therapeutic agents to specific components. However, the heterogeneity of tumors and individuals may limit the effectiveness of nanoparticle delivery systems in all types of tumors, calling for further understanding of TME changes at different stages of tumor development for the design of more personalized nanoplatforms.
BIOACTIVE MATERIALS
(2021)
Review
Immunology
Hassan Dianat-Moghadam, Reza Nedaeinia, Mohsen Keshavarz, Mehdi Azizi, Mohammad Kazemi, Rasoul Salehi
Summary: Angiogenesis is a characteristic of cancer biology, and current therapies targeting tumor vasculature have limitations. By combining immunotherapy and nanocarriers, the efficacy of antiangiogenic agents could be improved while reducing the dosage of chemotherapy drugs. Furthermore, the combination of immunotherapies and nano-based delivery systems can extend the window of vascular normalization and overcome the challenges of antiangiogenic agents in treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jun-Young Park, Jun Young Park, Yong-Gyu Jeong, Joo-Hwan Park, Yeon Ho Park, Sang-Hyun Kim, Dongwoo Khang
Summary: Due to stem cells' ability to specifically target tumor environments, stem-cell-membrane-functionalized nanocarriers can be used for targeted delivery of active anticancer drugs. This study focuses on self-targeting pancreatic cancer cells using stem cells. By utilizing the targeting abilities of stem cells, nano-polylactide-co-glycolide loaded with doxorubicin can be encapsulated within stem cell membranes, leading to targeted reduction of deep pancreatic tumor tissues. This platform technology can be applied to malignant tumors lacking surface target receptors, such as pancreatic tumor cells.
ADVANCED MATERIALS
(2023)
Article
Multidisciplinary Sciences
Ryuichi Ito, Masakazu Yashiro, Takuma Tsukioka, Nobuhiro Izumi, Hiroaki Komatsu, Hidetoshi Inoue, Noritoshi Nishiyama
Summary: A more accurate cut-off value of maximum standardized uptake value (SUVmax) based on PDH-E1 alpha expression in the primary lesion can improve preoperative nodal staging in lung cancer patients.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Biomedical
Yaoquan Su, Keqiang Lu, Yuhang Huang, Jingyu Zhang, Xiaolian Sun, Juanjuan Peng, Yunyun Zhou, Lingzhi Zhao
Summary: In this study, the inhibitor of glucose uptake and aerobic glycolysis, Salvianolic acid B, was combined with the photosensitizer chlorin e6 using a redox-responsive micelle. The results showed that Salvianolic acid B suppressed glucose metabolism and delayed oxygen consumption, significantly improving the efficacy of photodynamic therapy both in vitro and in vivo. This study not only offers an alternative strategy to address tumor hypoxia in photodynamic therapy, but also enhances treatment selectivity by targeting the cancer-specific Warburg effect.
Article
Engineering, Biomedical
Shiqing Ma, Shendan Xu, Minting Li, Yaqi Du, Guangjie Tian, Jiayin Deng, Wenyi Zhang, Pengfei Wei, Bo Zhao, Xuesong Zhang, Zihao Liu, Yonglan Wang
Summary: Restoring bone homeostasis is crucial for osteoporosis treatment. Short peptides with biological activity have gained attention, but their application is limited due to the lack of a stable and targeted delivery system. This study proposes a novel delivery system using AL-PLGA@P NPs to deliver osteogenic peptides, which has the ability to target bone and regulate bone homeostasis, providing advantages in osteoporosis treatment.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Huan Shi, Lan Chen, Yanlin Liu, Qinglian Wen, Sheng Lin, Qian Wen, Yun Lu, Jie Dai, Jianmei Li, Susu Xiao, Shaozhi Fu
Summary: A new Bifidobacterium infantis (Bif)-based biohybrid (Bif@PDA-PTX-NPs) was designed to deliver polydopamine (PDA)-coated paclitaxel nanoparticles (PTX-NPs) to tumor tissues. Bif@PDA-PTX-NPs maintained the toxicity of PTX and the hypoxic homing tendency of Bif, significantly inhibiting the growth of A549 xenografts in nude mice and prolonging the survival of tumor-bearing mice.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Susu Xiao, Huan Shi, Yan Zhang, Yu Fan, Li Wang, Li Xiang, Yanlin Liu, Ling Zhao, Shaozhi Fu
Summary: Local hypoxia is a common feature of solid tumors. In this study, a biocompatible bacteria/nanoparticles biohybrid platform was developed to target breast tumors. The results showed that the biohybrid was able to effectively colonize hypoxic tumors, increasing drug accumulation and reducing toxic side-effects.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yabing Xing, Xiao Li, Weiwei Cui, Meng Xue, Yanan Quan, Xinhong Guo
Summary: Structuring nanoparticles with glucose as a target is an effective strategy to enhance oral bioavailability and anti-tumor effects of drugs. In this study, a novel drug delivery system using glucose-modified zein nanoparticles loaded with docetaxel was prepared and characterized. The results showed that the glucose modification significantly enhanced cellular uptake and absorption of the nanoparticles, prolonged the drug's residence time in the body, and increased its oral bioavailability. The modified nanoparticles also reduced drug distribution in certain organs and increased tumor distribution and growth inhibition rate without causing systemic toxicity. These findings demonstrate the potential of glucose-modified zein nanoparticles as nanocarriers for enhancing the efficacy of oral drugs and their anti-tumor effects.
Review
Pharmacology & Pharmacy
Peijie Wu, Jun Han, Yanju Gong, Chao Liu, Han Yu, Na Xie
Summary: Cancer immunotherapy has shown promising results in improving long-term survival of patients with malignant tumors. However, current immunotherapy is limited by factors such as low specificity, poor response rate, and toxicities. Recent attention has been focused on targeting the tumor microenvironment to enhance the effectiveness of immunotherapy. Nanoplatforms, with their unique features, have the potential to improve immunotherapy outcomes while minimizing side effects.
Article
Chemistry, Multidisciplinary
Luntao Liu, Qingqing Li, Lanlan Chen, Lihong Song, Xueqiang Zhang, Hongqi Huo, Zhixin You, Ying Wu, Zongsheng Wu, Jiamin Ye, Qinrui Fu, Lichao Su, Xuan Zhang, Huanghao Yang, Jibin Song
Summary: In this study, multifunctional photocatalysis-powered nanomotors were developed for synergistically enhanced cancer radiotherapy. The nanomotors showed superior motility and efficient accumulation in tumor due to the catalytic generation of hydrogen. The nanomotors also exhibited a high radiation dose deposition, leading to enhanced therapeutic efficacy.
Article
Chemistry, Medicinal
Yan Liu, Jiaqing Huang, Min Wu, Bi Liu, Qiaofa Lin, Jingjing Wu, Yuhua Ouyang, Xin Guo, Ruyi Huang, Yongmin Zhang, Jianhua Xu
Summary: Six positional isomers of triptolide-glucose conjugates (TG1 alpha, TG1 beta, TG2, TG3, TG4 and TG6) were synthesized and showed improved water solubility. Among them, TG2, formed by triptolide and D-glucose, exhibited the strongest cytotoxicity to tumor cells and the lowest toxicity to non-tumor cells, resulting in the highest relative therapeutic index and the most powerful selective antitumor activity in vitro.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Haifeng Liang, Yiran Yan, Wei Sun, Xiaogang Ma, Zhiwen Su, Zhongxun Liu, Yan Chen, Bo Yu
Summary: This study evaluates the effects of melatonin on ROS and the innate immune response system in OA chondrocytes and the therapeutic effect in vivo, and proposes a new approach for treating osteoarthritis using a melatonin-loaded nano-delivery system. The results show that melatonin improves cartilage matrix metabolism and delays the progression of OA by inhibiting the TLR2/4-MyD88-NFκB signal pathway and scavenging ROS. The melatonin-loaded nano-delivery system can accumulate in cartilage, reduce the number of intra-articular injections, and improve the utilization rate of melatonin in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Lu-Yi Yu, Pei-Wei Shueng, Hsin-Cheng Chiu, Yu-Wei Yen, Tzu-Yu Kuo, Chieh-Ru Li, Ming-Wei Liu, Chia-Hsin Ho, Tzu-Hao Ho, Bo-Wei Wang, Cheng-En Li, Ming-Hung Chen, Yao-An Shen, Chun-Liang Lo
Summary: Tumour hypoxia plays a crucial role in various aspects of cancer progression, including angiogenesis, invasion, immunosuppression, and stemness maintenance. By targeting the glucose transporter 1 (GLUT1)-mediated transcytosis, a potential therapeutic strategy for tumor hypoxia was developed. Glucosamine-labeled liposomal ceramide was efficiently transported by GLUT1 and accumulated in the hypoxic area, while exogenous ceramide showed significant effects on tumor hypoxia and disrupted key signaling pathways.
Article
Chemistry, Multidisciplinary
Po-Yu Chou, Shyr-Yi Lin, Yi-No Wu, Chia-Yu Shen, Ming-Thau Sheu, Hsiu-O Ho
Summary: In this study, glycosylated poly(lactic-co-glycolic acid) nanoparticles (NPs) loaded with tumor-specific antigens and adjuvants were developed for targeted delivery to dendritic cells (DCs). The results showed that the glycosylated NPs effectively enhanced antigen uptake and DC maturation, and promoted cellular immunity and T-cell recruitment into tumor sites in vivo.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Sungyun Kim, Song Yi Lee, Hyun-Jong Cho
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Ja Seong Koo, Song Yi Lee, Suyeong Nam, Md Obyedul Kalam Azad, Minju Kim, Kwangyeol Kim, Byung-Jo Chae, Wie-Soo Kang, Hyun-Jong Cho
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Biophysics
Suyeong Nam, Song Yi Lee, Jung-Jin Kim, Wie-Soo Kang, In-Soo Yoon, Hyun-Jong Cho
COLLOIDS AND SURFACES B-BIOINTERFACES
(2018)
Article
Biochemistry & Molecular Biology
Song Yi Lee, Hyun-Jong Cho
Article
Biochemistry & Molecular Biology
Jin-Wook Kang, Hyun-Jong Cho, Hyo Jung Lee, Hyo-Eon Jin, Han-Joo Maeng
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Article
Pharmacology & Pharmacy
Ja Seong Koo, Song Yi Lee, Md Obyedul Kalam Azad, Minju Ki, Sung Jun Hwang, Suyeong Nam, Sungyun Kim, Byung-Jo Chae, Wie-Soo Kang, Hyun-Jong Cho
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2019)
Article
Chemistry, Physical
Song Yi Lee, Ja Seong Koo, Mingyu Yang, Hyun-Jong Cho
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2019)
Article
Biochemistry & Molecular Biology
JunHyung Lee, Abdolreza Hosseindoust, MinJu Kim, KwangYeol Kim, YoHan Choi, SeokHee Lee, SongYi Lee, HyunJong Cho, Wei Soo Kang, ByungJo Chae
BIOLOGICAL TRACE ELEMENT RESEARCH
(2020)
Review
Pharmacology & Pharmacy
Ki-Taek Kim, Jae-Young Lee, Dae-Duk Kim, In-Soo Yoon, Hyun-Jong Cho
Article
Pharmacology & Pharmacy
Chao-Feng Mu, Fude Cui, Yong-Mei Yin, Hyun-Jong Cho, Dae-Duk Kim
Article
Pharmacology & Pharmacy
Min-Hwan Kim, Ju-Hwan Park, Duy-Thuc Nguyen, Sungyun Kim, Da In Jeong, Hyun-Jong Cho, Dae-Duk Kim
Summary: An HAase inhibitor-incorporated hyaluronic acid hydrogel was designed to reduce toxicity risk and slow biodegradation rate in subcutaneous tissue. The hydrogel, formulated with Quercetin as an HAase inhibitor and quetiapine as a model drug, exhibited sustained drug release and improved pharmacokinetic parameters in rats following subcutaneous injection. All results supported the designed hydrogel as a biocompatible formulation for sustained drug delivery.
Article
Pharmacology & Pharmacy
Nae-Won Kang, So-Yeon Yoon, Sungho Kim, Na-Young Yu, Ju-Hwan Park, Jae-Young Lee, Hyun-Jong Cho, Dae-Duk Kim
Summary: The study developed a hybrid hydrogel containing microstructured lipid carriers and human serum albumin for sustained release of donepezil, which prolonged drug release and reduced initial plasma concentration in rats. The hydrogel exhibited good biocompatibility and therapeutic efficacy.
Article
Materials Science, Biomaterials
Song Yi Lee, Eun-Hye Hong, Jae Young Jeong, Jaewon Cho, Ji-Hye Seo, Hyun-Jeong Ko, Hyun-Jong Cho
BIOMATERIALS SCIENCE
(2019)
Article
Agriculture, Dairy & Animal Science
JunHyung Lee, Abdolreza Hosseindoust, MinJu Kim, KwangYeol Kim, YoHan Choi, Joseph Moturi, ChangHyun Song, SongYi Lee, HyunJong Cho, ByungJo Chae
JOURNAL OF ANIMAL SCIENCE AND TECHNOLOGY
(2019)
Review
Pharmacology & Pharmacy
Hyun-Jong Cho
JOURNAL OF PHARMACEUTICAL INVESTIGATION
(2020)