Article
Chemistry, Physical
Qun Yu, De-chang Li, Zhengbin Tian, Chongzhi Zhu, Chengli Jiao, Qian Zhang, Yanping Chen, Yihan Zhu, Heqing Jiang, Jian Liu, Guang-Hui Wang
Summary: In this study, a facile and scalable method for synthesizing single-hole hollow carbon nanospheres (HCH) using poly(ethylene glycol) (PEG)-assisted emulsion templating is developed. The HCH exhibits higher adsorption capacities and faster adsorption rates, indicating the enhancement of liquid-phase adsorption induced by the single-hole hollow structure.
CHEMISTRY OF MATERIALS
(2022)
Article
Biophysics
Rahul Chadar, Obaid Afzal, Safar M. Alqahtani, Prashant Kesharwani
Summary: Carbon nanotubes (CNTs) as a versatile nanocarrier for doxorubicin (DOX) delivery have attracted significant attention in pharmaceutical drug delivery. Their properties such as high surface area, high drug loading capacity, and ease of functionalization make them preferred nanocarriers for multipurpose drug delivery systems. The surface properties of CNTs can be easily modified by covalent/noncovalent functionalization, allowing for a profound nanomaterial with various applications in drug delivery.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Chemistry, Applied
Jaya R. Lakkakula, Pratik Gujarathi, Prachi Pansare, Swastika Tripathi
Summary: Combining alginate with other materials as a drug delivery system can effectively enhance the targeted therapeutic effects of doxorubicin on cancer, showing great potential for widespread applications.
CARBOHYDRATE POLYMERS
(2021)
Article
Medicine, Research & Experimental
Pawel Wolski
Summary: The research investigated the combined effect of the amount of oxygen-containing groups on the carbon quantum dot surface and the pH level on the interaction mechanism between an anticancer drug and a carrier. The study found that the strength of interaction between CQDs and DOX increases with surface coverage and pH, with electrostatic interactions playing a significant role in drug loading. Molecular dynamics simulations provided a microscopic view of DOX loading and release on/from CQDs, which is crucial for the development of advanced CQD-based targeted drug delivery systems.
MOLECULAR PHARMACEUTICS
(2021)
Article
Chemistry, Physical
Junfeng Zhang, Chenchen Li, Qianghua Xue, Xuelian Yin, Yajie Li, Wen He, Xuerui Chen, Jian Zhang, Rui L. Reis, Yanli Wang
Summary: The study developed a new nanodrug delivery system using carbon-based nanomaterials as a carrier for doxorubicin, effectively increasing the accumulation of DOX in tumor cell nuclei and tissues, leading to tumor growth inhibition.
Article
Chemistry, Multidisciplinary
Tao Wang, Liangliang Zhang, Jiaming Gu, Jingwei Liu, Zhilin Liu, Yu Xie, Hanyu Liu, Ling Zhang, Zhen-An Qiao
Summary: Synthetic polymer-derived hollow carbon spheres have practical value in many fields, and the synthesis of suitable polymer precursors is crucial. Exploring new polymer precursors and constructing refined hollow structures are important for synthetic methodology and novel carbon materials. In this study, Schiff base polymer (SBP) colloid spheres with refined hollow structures were synthesized using a tandem gradient growth and confined polymerization process.
Article
Nanoscience & Nanotechnology
Peitao Hu, Shun Dong, Fang Yuan, Xiutao Li, Changqing Hong
Summary: In this study, a superior microwave absorbent consisting of NiCo2S4 nanosheets anchored on hollow carbon spheres was successfully designed and fabricated for the first time by a low-cost and facile strategy. The obtained C/NiCo2S4 composite showed excellent absorption performance with a minimum reflection loss of -65.10 dB and an effective absorption bandwidth of 6.60 GHz at a thin thickness of 1.75 mm. The presence of NiCo2S4 nanosheets balanced the impedance matching property and enhanced the dielectric loss effectively, while the cavity structure promoted multiple reflections of the electromagnetic wave, increasing the material's energy loss capacity.
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Kaengwon Yoon, Seunggon Jung, Jaeyoung Ryu, Hong-Ju Park, Hee-Kyun Oh, Min-Suk Kook
Summary: ROS-sensitive polymer nanoparticles were synthesized for tumor targeting of doxorubicin. The nanoparticles showed ROS sensitivity and cytotoxicity against both sensitive and resistant cancer cells. In vivo studies demonstrated that the nanoparticles had higher antitumor efficacy and accumulated effectively in tumor tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Alvaro Carcamo-Martinez, Bronach Mallon, Juan Dominguez-Robles, Lalitkumar K. Vora, Qonita K. Anjani, Ryan F. Donnelly
Summary: Microneedles have the potential to be a highly progressive device for drug delivery and monitoring purposes by penetrating the skin and piercing the stratum corneum barrier. Hollow microneedles have entered the pharmaceutical market as medical devices, with continuous development in materials and methods for fabrication, and expanding applications in drug delivery, vaccine delivery, and monitoring.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Dorota Chudoba, Monika Jazdzewska, Katarzyna Ludzik, Sebastian Woloszczuk, Ewa Juszynska-Galazka, Mikolaj Koscinski
Summary: This article discusses the release process of doxorubicin hydrochloride from multi-wall carbon nanotubes and the studies on the modified surface for optimization. Experimental observations suggest that drug release is efficient at acidic pH, typical of tumor microenvironment. Kinetic models and molecular dynamics simulations provide insights into the controlled drug release mechanism of DOX from MWCNTs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Xiao-Fei Yu, Wen-Cui Li, You-Ren Hu, Cheng-Yu Ye, An-Hui Lu
Summary: A new synthesis approach for internal gridded hollow carbon spheres is proposed in this study, which involves constructing a silica fence around solid polymer spheres to create the desired structure. These carbon spheres show good performance as sulfur hosts for Li-S batteries.
Article
Chemistry, Multidisciplinary
Ceren Kimna, Theresa Monika Lutz, Hongji Yan, Jian Song, Thomas Crouzier, Oliver Lieleg
Summary: A nanoparticle-based drug delivery system has been designed to release therapeutic agents into disease cells based on specific DNA sequences, showing potential for targeted treatments of specific diseases.
Article
Chemistry, Physical
Na Liu, Fan Fan, Wei Xu, Hao Zhang, Qi Zhou, Xiaopeng Li
Summary: Hollow structured WS2 particles with large surface area were utilized for drug delivery, requiring surface modification and drug loading. Various analyses confirmed the loading and release of PEG and DOX, while the specific surface area was determined. The drug release and biocompatibility were studied with liver tumor cells.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Chemistry, Multidisciplinary
D. Sahoo, T. Mitra, K. Chakraborty, P. Sarkar
Summary: This study developed a new electric field responsive graphene oxide nanoparticle system for on-demand drug delivery, showcasing remote control of dual drugs (aspirin and doxorubicin) release and observing their synergistic antitumor activity in breast cancer cells in vitro.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Xin Lu, Qing Han, Jiachen Chen, Tingyu Wu, Yirui Cheng, Fan Li, Weiliang Xia
Summary: Extracellular vesicles (EVs) released from cells have shown robust efficacy in drug delivery compared with traditional synthetic carriers. However, the clinical application of EVs as drug carriers is limited due to high production cost and complex purification process. Plant-derived nanovesicles with exosome-like morphology and similar delivery effects could be a new option for drug delivery. Celery exosome-like nanovesicles (CELNs), as a drug carrier, have higher cellular uptake efficiency and better tolerance as biotherapeutic roles verified in mice models. Encapsulating doxorubicin (DOX) into CELNs to construct engineered CELNs (CELNs-DOX) has proved to be more efficient in treating tumors than conventional synthetic carriers like liposome both in vitro and in vivo. This study proposes the emerging role of CELNs as a new-generation drug delivery carrier with distinct advantages.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Genetics & Heredity
Xiaochen Wang, Qifeng He, Haiyuan Shen, Xiao-Jie Lu, Beicheng Sun
JOURNAL OF MEDICAL GENETICS
(2019)
Review
Cell Biology
Jin-Cheng Wang, An-Liang Xia, Yong Xu, Xiao-Jie Lu
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Cell Biology
Yong-Fa Zheng, Xiaojie Lu, Xiao-Yu Zhang, Bu-Gao Guan
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Review
Cell Biology
Jin-Yu Sun, Tai-Lang Yin, Jianhua Zhou, Jiang Xu, Xiao-Jie Lu
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Article
Cell Biology
Dong Ji, Guo-Feng Chen, Jin-Cheng Wang, Si-Han Ji, Xue-Wen Wu, Xiao-Jie Lu, Jin-Lian Chen, Jing-Tao Li
Editorial Material
Oncology
Xiao-Jie Lu
Editorial Material
Oncology
Jin-Yu Sun, Xiao-Jie Lu
Review
Oncology
Jin-Yu Sun, Dengke Zhang, Songquan Wu, Min Xu, Xiao Zhou, Xiao-Jie Lu, Jiansong Ji
BIOMARKER RESEARCH
(2020)
Article
Oncology
Xiao-Jie Lu, Xiao-Jun Yang, Jing-Yu Sun, Xin Zhang, Zhao-Xin Yuan, Xiu-Hui Li
BIOMARKER RESEARCH
(2020)
Editorial Material
Genetics & Heredity
Xiaoling Weng, Xiao-Jie Lu
Article
Cell Biology
Jianfei Tu, Weiqian Chen, Liyun Zheng, Shiji Fang, Dengke Zhang, Chunli Kong, Yang Yang, Rongfang Qiu, Zhongwei Zhao, Chenying Lu, Xiaojie Lu, Jiansong Ji
Summary: The study revealed that circ_0021205 was up-regulated in CCA and positively correlated with tumor size and TNM stage. It promoted the proliferation, migration, and invasion of CCA cells by sponging miR-204-5p and regulating the expression of RAB22A, serving as a potential diagnostic biomarker or therapeutic target for CCA.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Jin-Yu Sun, Rui Wu, Jiang Xu, Hui-Ying Xue, Xiao-Jie Lu, Jiansong Ji
Summary: The immune system plays a crucial role in recognizing and attacking non-self antigens, leading to immunity against infection. However, it also causes immune rejection during organ transplantation. Understanding the mechanisms of maternal-fetal immune tolerance can potentially improve transplantation outcomes by balancing immune tolerance and infection defense. Studies exploring the interconnection between immune tolerance in pregnancy and organ transplantation highlight the impact of pregnancy alloimmunization on transplant success.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Cell Biology
Xiaoling Weng, Xiao-Jie Lu
CELLULAR SIGNALLING
(2021)
Article
Cell Biology
Xiaochen Wang, Jianchu Wang, Haiyuan Shen, Zongjiang Luo, Xiaojie Lu
Summary: This study found that TPX2 regulates the antitumor effect of CD8 + T cells in hepatocellular carcinoma (HCC) by modulating CXCR5. Overexpression of TPX2 enhances the anticancer function of CD8 + T cells and shows synergistic effects with anti-PD-1 therapy.
CELL DEATH & DISEASE
(2022)
Review
Oncology
David Prince, Ken Liu, Weiqi Xu, Minjiang Chen, Jin-Yu Sun, Xiao-Jie Lu, Jiansong Ji
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2020)