Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 18, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/ijms18102149
Keywords
reactive oxygen species; NADPH oxidase; NOX enzymes; wound repair; wound healing; chronic wounds; wound contraction; re-epithelialization; hyperbaric oxygen therapy; oxidative stress
Funding
- Swiss National Science Foundation [310030_120571]
- South African Medical Research Council (University Flagship and Extramural Stem Cell Unit awards
- Swiss National Science Foundation (SNF) [310030_120571] Funding Source: Swiss National Science Foundation (SNF)
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Our understanding of the role of oxygen in cell physiology has evolved from its long-recognized importance as an essential factor in oxidative metabolism to its recognition as an important player in cell signaling. With regard to the latter, oxygen is needed for the generation of reactive oxygen species (ROS), which regulate a number of different cellular functions including differentiation, proliferation, apoptosis, migration, and contraction. Data specifically concerning the role of ROS-dependent signaling in cutaneous wound repair are very limited, especially regarding wound contraction. In this review we provide an overview of the current literature on the role of molecular and reactive oxygen in the physiology of wound repair as well as in the pathophysiology and therapy of chronic wounds, especially under ischemic and hyperglycemic conditions.
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