期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 18, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/ijms18102149
关键词
reactive oxygen species; NADPH oxidase; NOX enzymes; wound repair; wound healing; chronic wounds; wound contraction; re-epithelialization; hyperbaric oxygen therapy; oxidative stress
资金
- Swiss National Science Foundation [310030_120571]
- South African Medical Research Council (University Flagship and Extramural Stem Cell Unit awards
- Swiss National Science Foundation (SNF) [310030_120571] Funding Source: Swiss National Science Foundation (SNF)
Our understanding of the role of oxygen in cell physiology has evolved from its long-recognized importance as an essential factor in oxidative metabolism to its recognition as an important player in cell signaling. With regard to the latter, oxygen is needed for the generation of reactive oxygen species (ROS), which regulate a number of different cellular functions including differentiation, proliferation, apoptosis, migration, and contraction. Data specifically concerning the role of ROS-dependent signaling in cutaneous wound repair are very limited, especially regarding wound contraction. In this review we provide an overview of the current literature on the role of molecular and reactive oxygen in the physiology of wound repair as well as in the pathophysiology and therapy of chronic wounds, especially under ischemic and hyperglycemic conditions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据