In Vivo Imaging of Microglial Calcium Signaling in Brain Inflammation and Injury

Complex Roles of Microglial Cells in Ischemic Stroke Pathobiology: New Insights and Future Directions

(2017) Revathy Guruswamy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exploring the role of microglia in cortical spreading depression in neurological disease

(2017) Mamoru Shibata et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging

(2017) Petra Füger et al.   NATURE NEUROSCIENCE

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

(2017) Edsel M. Abud et al.   NEURON

Neuroprotective strategies and the underlying molecular basis of cerebrovascular stroke

(2017) Michael Karsy et al.   Neurosurgical Focus

The Lifespan and Turnover of Microglia in the Human Brain

(2017) Pedro Réu et al.   Cell Reports

A new approach for ratiometric in vivo calcium imaging of microglia

(2017) Bianca Brawek et al.   Scientific Reports

TLR2 controls random motility, while TLR7 regulates chemotaxis of microglial cells via distinct pathways

(2016) Masataka Ifuku et al.   BRAIN BEHAVIOR AND IMMUNITY

New insights on the role of microglia in synaptic pruning in health and disease

(2016) Soyon Hong et al.   CURRENT OPINION IN NEUROBIOLOGY

Microglia-Neuron Communication in Epilepsy

(2016) Ukpong B. Eyo et al.   GLIA

Requisite ischemia for spreading depolarization occurrence after subarachnoid hemorrhage in rodents

(2016) Fumiaki Oka et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mechanisms of spreading depolarization in vertebrate and insect central nervous systems

(2016) Kristin E. Spong et al.   JOURNAL OF NEUROPHYSIOLOGY

Efficient derivation of microglia-like cells from human pluripotent stem cells

(2016) Julien Muffat et al.   NATURE MEDICINE

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Probing the Complexities of Astrocyte Calcium Signaling

(2016) Eiji Shigetomi et al.   TRENDS IN CELL BIOLOGY

Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke

(2016) Gergely Szalay et al.   Nature Communications

GPR84 deficiency reduces microgliosis, but accelerates dendritic degeneration and cognitive decline in a mouse model of Alzheimer’s disease

(2015) Julie Audoy-Rémus et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuroinflammatory TNFα Impairs Memory via Astrocyte Signaling

(2015) Samia Habbas et al.   CELL

STIM and ORAI proteins in the nervous system

(2015) Robert Kraft   Channels

Receptors, Ion Channels, and Signaling Mechanisms Underlying Microglial Dynamics

(2015) Christian Madry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Molecular Spies for Bioimaging—Fluorescent Protein-Based Probes

(2015) Atsushi Miyawaki et al.   MOLECULAR CELL

The Stroke-Migraine Depolarization Continuum

(2015) Jens P. Dreier et al.   NEURON

Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature

(2015) Cenk Ayata et al.   PHYSIOLOGICAL REVIEWS

Imaging activity in astrocytes and neurons with genetically encoded calcium indicators following in utero electroporation

(2015) J. Michael Gee et al.   Frontiers in Molecular Neuroscience

Intracellular calcium dynamics in cortical microglia responding to focal laser injury in the PC::G5-tdT reporter mouse

(2015) Amir Pozner et al.   Frontiers in Molecular Neuroscience

Impairment of in vivo calcium signaling in amyloid plaque-associated microglia

(2014) Bianca Brawek et al.   ACTA NEUROPATHOLOGICA

Tumor necrosis factor reduces the amplitude of rat cortical spreading depressionin vivo

(2014) Frank Richter et al.   ANNALS OF NEUROLOGY

Cannabidiol enhances microglial phagocytosis via transient receptor potential (TRP) channel activation

(2014) Samia Hassan et al.   BRITISH JOURNAL OF PHARMACOLOGY

STIM1, STIM2, and Orai1 regulate store-operated calcium entry and purinergic activation of microglia

(2014) Marlen Michaelis et al.   GLIA

Altered microglial phagocytosis in GPR34-deficient mice

(2014) Julia Preissler et al.   GLIA

Systemic inflammation regulates microglial responses to tissue damagein vivo

(2014) Stefka Gyoneva et al.   GLIA

Spreading depression requires microglia and is decreased by their M2a polarization from environmental enrichment

(2014) Kae M. Pusic et al.   GLIA

Brain-derived Neurotrophic Factor (BDNF) Induces Sustained Intracellular Ca2+Elevation through the Up-regulation of Surface Transient Receptor Potential 3 (TRPC3) Channels in Rodent Microglia

(2014) Yoshito Mizoguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Morphometric characterization of microglial phenotypes in human cerebral cortex

(2014) Susana G Torres-Platas et al.   Journal of Neuroinflammation

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Optimized ratiometric calcium sensors for functional in vivo imaging of neurons and T lymphocytes

(2014) Thomas Thestrup et al.   NATURE METHODS

Chaos and commotion in the wake of cortical spreading depression and spreading depolarizations

(2014) Daniela Pietrobon et al.   NATURE REVIEWS NEUROSCIENCE

Imaging Activity in Neurons and Glia with a Polr2a-Based and Cre-Dependent GCaMP5G-IRES-tdTomato Reporter Mouse

(2014) J. Michael Gee et al.   NEURON

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Astrogliosis

(2014) Michael V. Sofroniew   Cold Spring Harbor Perspectives in Biology

TREM2 and the neuroimmunology of Alzheimer's disease

(2013) Suzanne E. Hickman et al.   BIOCHEMICAL PHARMACOLOGY

Norepinephrine Modulates the Motility of Resting and Activated Microglia via Different Adrenergic Receptors

(2013) Stefka Gyoneva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin-like growth factor-1 abrogates microglial oxidative stress and TNF-α responses to spreading depression

(2013) Yelena Y. Grinberg et al.   JOURNAL OF NEUROCHEMISTRY

Ultrasensitive fluorescent proteins for imaging neuronal activity

(2013) Tsai-Wen Chen et al.   NATURE

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology

(2013) Grietje Krabbe et al.   PLoS One

Visualization and genetic modification of resident brain microglia using lentiviral vectors regulated by microRNA-9

(2013) Malin Åkerblom et al.   Nature Communications

Using Exome Sequencing to Reveal Mutations in TREM2 Presenting as a Frontotemporal Dementia–like Syndrome Without Bone Involvement

(2013) Rita João Guerreiro et al.   JAMA Neurology

Aging and the neurovascular unit

(2012) Gregory J. del Zoppo   Annals of the New York Academy of Sciences

Insulin-like growth factor-1 lowers spreading depression susceptibility and reduces oxidative stress

(2012) Yelena Y. Grinberg et al.   JOURNAL OF NEUROCHEMISTRY

Optimization of a GCaMP Calcium Indicator for Neural Activity Imaging

(2012) J. Akerboom et al.   JOURNAL OF NEUROSCIENCE

A Cre-Dependent GCaMP3 Reporter Mouse for Neuronal Imaging In Vivo

(2012) H. A. Zariwala et al.   JOURNAL OF NEUROSCIENCE

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells

(2012) N. H. Varvel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced dynamic range in a genetically encoded Ca2+ sensor

(2011) Shun Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Transmitter- and hormone-activated Ca2+ responses in adult microglia/brain macrophages in situ recorded after viral transduction of a recombinant Ca2+ sensor

(2011) Stefanie Seifert et al.   CELL CALCIUM

Role of microglia in CNS inflammation

(2011) Manuel B. Graeber et al.   FEBS LETTERS

Two-photon absorption properties of fluorescent proteins

(2011) Mikhail Drobizhev et al.   NATURE METHODS

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

The Sterile Inflammatory Response

(2010) Kenneth L. Rock et al.   Annual Review of Immunology

Microglial calcium signal acts as a rapid sensor of single neuron damage in vivo

(2010) Gerhard Eichhoff et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Clinical Relevance of Cortical Spreading Depression in Neurological Disorders: Migraine, Malignant Stroke, Subarachnoid and Intracranial Hemorrhage, and Traumatic Brain Injury

(2010) Martin Lauritzen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Distinctive Response of CNS Glial Cells in Orofacial Pain Associated with Injury, Infection and Inflammation

(2010) SeungHwan Lee et al.   Molecular Pain

Store-operated CRAC channels: function in health and disease

(2010) Anant B. Parekh   NATURE REVIEWS DRUG DISCOVERY

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

Selective Chemokine Receptor Usage by Central Nervous System Myeloid Cells in CCR2-Red Fluorescent Protein Knock-In Mice

(2010) Noah Saederup et al.   PLoS One

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Microglial Interactions with Synapses Are Modulated by Visual Experience

(2010) Marie-Ève Tremblay et al.   PLOS BIOLOGY

Immune and Inflammatory Mechanisms of Atherosclerosis

(2009) Elena Galkina et al.   Annual Review of Immunology

Microglia processes block the spread of damage in the brain and require functional chloride channels

(2009) Dustin J. Hines et al.   GLIA

Activation of Microglia by Amyloid   Requires P2X7 Receptor Expression

(2009) J. M. Sanz et al.   JOURNAL OF IMMUNOLOGY

Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals

(2009) H. Wake et al.   JOURNAL OF NEUROSCIENCE

Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators

(2009) Lin Tian et al.   NATURE METHODS

Crystal Structures of the GCaMP Calcium Sensor Reveal the Mechanism of Fluorescence Signal Change and Aid Rational Design

(2008) Jasper Akerboom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A FLEX Switch Targets Channelrhodopsin-2 to Multiple Cell Types for Imaging and Long-Range Circuit Mapping

(2008) D. Atasoy et al.   JOURNAL OF NEUROSCIENCE

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Calcium signaling in immune cells

(2008) Monika Vig et al.   NATURE IMMUNOLOGY

Structural Basis for Calcium Sensing by GCaMP2

(2008) Qi Wang et al.   STRUCTURE