Increased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1

Hypothalamic Sirt1 in aging

(2016) Akiko Satoh et al.   Aging-US

Pharmacokinetic Profiles of Active Ingredients and Its Metabolites Derived from Rikkunshito, a Ghrelin Enhancer, in Healthy Japanese Volunteers: A Cross-Over, Randomized Study

(2015) Hiroyuki Kitagawa et al.   PLoS One

Minireview: Central Sirt1 Regulates Energy Balance via the Melanocortin System and Alternate Pathways

(2014) Anika M. Toorie et al.   MOLECULAR ENDOCRINOLOGY

Administration of exogenous acylated ghrelin or rikkunshito, an endogenous ghrelin enhancer, improves the decrease in postprandial gastric motility in an acute restraint stress mouse model

(2014) M. Nahata et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Rikkunshito ameliorates cachexia associated with bleomycin-induced lung fibrosis in mice by stimulating ghrelin secretion

(2014) Hironobu Tsubouchi et al.   NUTRITION RESEARCH

Effects of an Oral Ghrelin Mimetic on Body Composition and Clinical Outcomes in Healthy Older Adults

(2013) Ralf Nass et al.   ANNALS OF INTERNAL MEDICINE

Rapalogs and mTOR inhibitors as anti-aging therapeutics

(2013) Dudley W. Lamming et al.   JOURNAL OF CLINICAL INVESTIGATION

Chinese agriculture: An experiment for the world

(2013) Fusuo Zhang et al.   NATURE

Cachexia and Herbal Medicine: Perspective

(2012) Hajime Suzuki et al.   CURRENT PHARMACEUTICAL DESIGN

Clinical Application of Ghrelin

(2012) Florian Strasser   CURRENT PHARMACEUTICAL DESIGN

Diverse Roles of Growth Hormone and Insulin-Like Growth Factor-1 in Mammalian Aging: Progress and Controversies

(2012) W. E. Sonntag et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Calorie restriction falters in the long run

(2012) Amy Maxmen   NATURE

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

(2012) Julie A. Mattison et al.   NATURE

Are sirtuins viable targets for improving healthspan and lifespan?

(2012) Joseph A. Baur et al.   NATURE REVIEWS DRUG DISCOVERY

Aging and Diets Regulate the Rat Anterior Pituitary and Hypothalamic Transcriptome

(2012) Karine Bédard et al.   NEUROENDOCRINOLOGY

Klotho protein diminishes endothelial apoptosis and senescence via a mitogen-activated kinase pathway

(2011) Yoshihiro Maekawa et al.   Geriatrics & Gerontology International

Ghrelin and cardiovascular diseases

(2011) Ichiro Kishimoto et al.   Journal of Cardiology

SIRT-1 and vascular endothelial dysfunction with ageing in mice and humans

(2011) Anthony J. Donato et al.   JOURNAL OF PHYSIOLOGY-LONDON

Caloric restriction

(2011) John R. Speakman et al.   MOLECULAR ASPECTS OF MEDICINE

A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction

(2011) S. Fusco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potentiation of ghrelin signaling attenuates cancer anorexia–cachexia and prolongs survival

(2011) N Fujitsuka et al.   Translational Psychiatry

Ghrelin inhibits insulin secretion through the AMPK-UCP2 pathway in β cells

(2010) Ying Wang et al.   FEBS LETTERS

The molecular basis by which dietary restricted feeding reduces mitochondrial reactive oxygen species generation

(2010) C.E. Ash et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Ageing

(2010) Marie-Thérèse Heemels   NATURE

AMPK and vasculoprotection

(2010) Marie-Ann Ewart et al.   PHARMACOLOGY & THERAPEUTICS

The extra-hypothalamic actions of ghrelin on neuronal function

(2010) Zane B. Andrews   TRENDS IN NEUROSCIENCES

Regulation of AMP-activated protein kinase by cAMP in adipocytes: Roles for phosphodiesterases, protein kinase B, protein kinase A, Epac and lipolysis

(2009) Bilal Omar et al.   CELLULAR SIGNALLING

Rikkunshito Ameliorates the Aging-Associated Decrease in Ghrelin Receptor Reactivity via Phosphodiesterase III Inhibition

(2009) Hiroshi Takeda et al.   ENDOCRINOLOGY

Effects of an Oral Growth Hormone Secretagogue in Older Adults

(2009) Heidi K. White et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Suppression of Experimental Autoimmune Encephalomyelitis by Ghrelin

(2009) M.-M. Theil et al.   JOURNAL OF IMMUNOLOGY

Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: Role of circulating factors and SIRT1

(2009) Anna Csiszar et al.   MECHANISMS OF AGEING AND DEVELOPMENT

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Ghrelin Gene Products and the Regulation of Food Intake and Gut Motility

(2009) C.-Y. Chen et al.   PHARMACOLOGICAL REVIEWS

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies

(2008) Marwan Maalouf et al.   BRAIN RESEARCH REVIEWS

Rikkunshito, an Herbal Medicine, Suppresses Cisplatin-Induced Anorexia in Rats Via 5-HT2 Receptor Antagonism

(2008) Hiroshi Takeda et al.   GASTROENTEROLOGY

UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals

(2008) Zane B. Andrews et al.   NATURE

Ghrelin raises [Ca2+]i via AMPK in hypothalamic arcuate nucleus NPY neurons

(2007) Daisuke Kohno et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS