To Wnt or Lose: The Missing Non-Coding Linc in Colorectal Cancer

Down regulation of the long non-coding RNA PCAT-1 induced growth arrest and apoptosis of colorectal cancer cells

(2017) Lei Qiao et al.   LIFE SCIENCES

Cellular uptake and trafficking of antisense oligonucleotides

(2017) Stanley T Crooke et al.   NATURE BIOTECHNOLOGY

Prognostic value of long non-coding RNA CCAT1 expression in patients with cancer: A meta-analysis

(2017) Deyao Shi et al.   PLoS One

Feedback circuitry via let-7c between lncRNA CCAT1 and c-Myc is involved in cigarette smoke extract-induced malignant transformation of HBE cells

(2017) Lu Lu et al.   Oncotarget

Long Noncoding RNA CCAT2 as a Potential Novel Biomarker to Predict the Clinical Outcome of Cancer Patients: A Meta-Analysis

(2017) Juan Tan et al.   Journal of Cancer

Long noncoding RNA H19 regulates EZH2 expression by interacting with miR-630 and promotes cell invasion in nasopharyngeal carcinoma

(2016) Xudong Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Long non-coding RNA CASC11 interacts with hnRNP-K and activates the WNT/β-catenin pathway to promote growth and metastasis in colorectal cancer

(2016) Zheying Zhang et al.   CANCER LETTERS

RBM5-AS1 Is Critical for Self-Renewal of Colon Cancer Stem-like Cells

(2016) Serena Di Cecilia et al.   CANCER RESEARCH

A miR-34a-Numb Feedforward Loop Triggered by Inflammation Regulates Asymmetric Stem Cell Division in Intestine and Colon Cancer

(2016) Pengcheng Bu et al.   Cell Stem Cell

Long noncoding RNA H19 inhibits the proliferation of fetal liver cells and the Wnt signaling pathway

(2016) Shaobing Wang et al.   FEBS LETTERS

Overexpression of long non-coding RNA-CTD903 inhibits colorectal cancer invasion and migration by repressing Wnt/β-catenin signaling and predicts favorable prognosis

(2016) ZIXU YUAN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer

(2016) Mark L. McCleland et al.   JOURNAL OF CLINICAL INVESTIGATION

Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2

(2016) Roxana S. Redis et al.   MOLECULAR CELL

Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer

(2016) Haiyang Guo et al.   NATURE GENETICS

ASBEL–TCF3 complex is required for the tumorigenicity of colorectal cancer cells

(2016) Kenzui Taniue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MYU, a Target lncRNA for Wnt/c-Myc Signaling, Mediates Induction of CDK6 to Promote Cell Cycle Progression

(2016) Yoshihiro Kawasaki et al.   Cell Reports

A Positive Regulatory Loop between a Wnt-Regulated Non-coding RNA and ASCL2 Controls Intestinal Stem Cell Fate

(2016) Antonis Giakountis et al.   Cell Reports

A long non-coding RNA targets microRNA miR-34a to regulate colon cancer stem cell asymmetric division

(2016) Lihua Wang et al.   eLife

H19 Noncoding RNA, an Independent Prognostic Factor, Regulates Essential Rb-E2F and CDK8-β-Catenin Signaling in Colorectal Cancer

(2016) Masahisa Ohtsuka et al.   EBioMedicine

Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides

(2015) Richard S. Geary et al.   ADVANCED DRUG DELIVERY REVIEWS

HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer

(2015) Paloma Ordóñez-Morán et al.   CANCER CELL

Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer

(2015) Lukas E. Dow et al.   CELL

Long non-coding RNA CCAL regulates colorectal cancer progression by activating Wnt/β-catenin signalling pathway via suppression of activator protein 2α

(2015) Yanlei Ma et al.   GUT

The H19 Long non-coding RNA in cancer initiation, progression and metastasis – a proposed unifying theory

(2015) Eli Raveh et al.   Molecular Cancer

The emerging role of lncRNAs in cancer

(2015) Maite Huarte   NATURE MEDICINE

Junk DNA and the long non-coding RNA twist in cancer genetics

(2015) H Ling et al.   ONCOGENE

H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase

(2015) Jichun Zhou et al.   Nature Communications

Histone H1.3 Suppresses H19 Noncoding RNA Expression and Cell Growth of Ovarian Cancer Cells

(2014) M. Medrzycki et al.   CANCER RESEARCH

Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus

(2014) Jian-Feng Xiang et al.   CELL RESEARCH

Current Status of Long Non-Coding RNAs in Human Cancer with Specific Focus on Colorectal Cancer

(2014) Maria Smolle et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PVT1 dependence in cancer with MYC copy-number increase

(2014) Yuen-Yi Tseng et al.   NATURE

MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells

(2014) Wei-Lun Hwang et al.   NATURE CELL BIOLOGY

miR-CLIP capture of a miRNA targetome uncovers a lincRNA H19–miR-106a interaction

(2014) Jochen Imig et al.   Nature Chemical Biology

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennaryN-acetyl galactosamine improves potency 10-fold in mice

(2014) Thazha P. Prakash et al.   NUCLEIC ACIDS RESEARCH

Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5

(2014) T. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-34a: a potential therapeutic target in human cancer

(2014) X J Li et al.   Cell Death & Disease

Amplification of PVT-1 is involved in poor prognosis via apoptosis inhibition in colorectal cancers

(2013) Y Takahashi et al.   BRITISH JOURNAL OF CANCER

Super-Enhancers in the Control of Cell Identity and Disease

(2013) Denes Hnisz et al.   CELL

CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer

(2013) H. Ling et al.   GENOME RESEARCH

Aspirin Use, 8q24 Single Nucleotide Polymorphism rs6983267, and Colorectal Cancer According to CTNNB1 Alterations

(2013) Hongmei Nan et al.   JNCI-Journal of the National Cancer Institute

Overexpression of long noncoding RNA PCAT-1 is a novel biomarker of poor prognosis in patients with colorectal cancer

(2013) Xiaosong Ge et al.   MEDICAL ONCOLOGY

The Imprinted H19 LncRNA Antagonizes Let-7 MicroRNAs

(2013) Amanda N. Kallen et al.   MOLECULAR CELL

MicroRNAs and other non-coding RNAs as targets for anticancer drug development

(2013) Hui Ling et al.   NATURE REVIEWS DRUG DISCOVERY

The Long and Winding Road to FDA Approval of a Novel Prostate Cancer Test: Our Story

(2012) H. Rittenhouse et al.   CLINICAL CHEMISTRY

Genome-wide analysis of long noncoding RNA stability

(2012) M. B. Clark et al.   GENOME RESEARCH

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Landscape of transcription in human cells

(2012) Sarah Djebali et al.   NATURE

The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r

(2012) Andrew Keniry et al.   NATURE CELL BIOLOGY

Mice Lacking a Myc Enhancer That Includes Human SNP rs6983267 Are Resistant to Intestinal Tumors

(2012) I. K. Sur et al.   SCIENCE

Silencing of the Wnt transcription factor TCF4 sensitizes colorectal cancer cells to (chemo-) radiotherapy

(2011) Emil Kendziorra et al.   CARCINOGENESIS

Molecular Mechanisms of Long Noncoding RNAs

(2011) Kevin C. Wang et al.   MOLECULAR CELL

Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression

(2011) John R Prensner et al.   NATURE BIOTECHNOLOGY

Non-coding RNAs in human disease

(2011) Manel Esteller   NATURE REVIEWS GENETICS

p53 and MicroRNA-34 Are Suppressors of Canonical Wnt Signaling

(2011) N. H. Kim et al.   Science Signaling

The histone variant macroH2A suppresses melanoma progression through regulation of CDK8

(2010) Avnish Kapoor et al.   NATURE

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

(2010) Louis Vermeulen et al.   NATURE CELL BIOLOGY

MicroRNA profiling identifies miR-34a and miR-21 and their target genes JAG1 and WNT1 in the coordinate regulation of dendritic cell differentiation

(2009) S. T. Hashimi et al.   BLOOD

Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate

(2009) Laurens G. van der Flier et al.   CELL

The miR-34 family in cancer and apoptosis

(2009) H Hermeking   CELL DEATH AND DIFFERENTIATION

The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer

(2009) Mark M Pomerantz et al.   NATURE GENETICS

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling

(2009) Sari Tuupanen et al.   NATURE GENETICS

Long non-coding RNAs: insights into functions

(2009) Tim R. Mercer et al.   NATURE REVIEWS GENETICS

Regulation of the Adenomatous Polyposis Coli Gene by the miR-135 Family in Colorectal Cancer

(2008) R. Nagel et al.   CANCER RESEARCH

Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest

(2008) Fang Sun et al.   FEBS LETTERS

The Identification of MicroRNAs in a Genomically Unstable Region of Human Chromosome 8q24

(2008) K. Huppi et al.   MOLECULAR CANCER RESEARCH

CDK8 is a colorectal cancer oncogene that regulates β-catenin activity

(2008) Ron Firestein et al.   NATURE

Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21

(2008) Albert Tenesa et al.   NATURE GENETICS