Optogenetic Investigation of Arousal Circuits

Excitation of GABAergic Neurons in the Bed Nucleus of the Stria Terminalis Triggers Immediate Transition from Non-Rapid Eye Movement Sleep to Wakefulness in Mice

(2017) Shota Kodani et al.   JOURNAL OF NEUROSCIENCE

Identification of preoptic sleep neurons using retrograde labelling and gene profiling

(2017) Shinjae Chung et al.   NATURE

A molecular census of arcuate hypothalamus and median eminence cell types

(2017) John N Campbell et al.   NATURE NEUROSCIENCE

Dorsal Raphe Dopamine Neurons Modulate Arousal and Promote Wakefulness by Salient Stimuli

(2017) Jounhong Ryan Cho et al.   NEURON

Decreased CSF Histamine in Narcolepsy With and Without Low CSF Hypocretin-1 in Comparison to Healthy Controls

(2017) Seiji Nishino et al.   SLEEP

CSF Histamine Contents in Narcolepsy, Idiopathic Hypersomnia and Obstructive Sleep Apnea Syndrome

(2017) Takashi Kanbayashi et al.   SLEEP

A Novel Population of Wake-Promoting GABAergic Neurons in the Ventral Lateral Hypothalamus

(2016) Anne Venner et al.   CURRENT BIOLOGY

VTA dopaminergic neurons regulate ethologically relevant sleep–wake behaviors

(2016) Ada Eban-Rothschild et al.   NATURE NEUROSCIENCE

Anxiolytic-like effects of leptin on fixed interval responding

(2016) Susan M. Tyree et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

(2015) Evan Z. Macosko et al.   CELL

Optogenetic stimulation of astrocytes in the posterior hypothalamus increases sleep at night in C57BL/6J mice

(2015) Dheeraj Pelluru et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Optogenetic Evidence for Inhibitory Signaling from Orexin to MCH Neurons via Local Microcircuits

(2015) J. Apergis-Schoute et al.   JOURNAL OF NEUROSCIENCE

Control of REM sleep by ventral medulla GABAergic neurons

(2015) Franz Weber et al.   NATURE

Basal forebrain circuit for sleep-wake control

(2015) Min Xu et al.   NATURE NEUROSCIENCE

Antagonistic interplay between hypocretin and leptin in the lateral hypothalamus regulates stress responses

(2015) Patricia Bonnavion et al.   Nature Communications

Multi-channel fiber photometry for population neuronal activity recording

(2015) Qingchun Guo et al.   Biomedical Optics Express

The frequency of hippocampal theta rhythm is modulated on a circadian period and is entrained by food availability

(2015) Robert G. K. Munn et al.   Frontiers in Behavioral Neuroscience

Orexin neurons suppress narcolepsy via 2 distinct efferent pathways

(2014) Emi Hasegawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Discharge Profiles across the Sleep-Waking Cycle of Identified Cholinergic, GABAergic, and Glutamatergic Neurons in the Pontomesencephalic Tegmentum of the Rat

(2014) S. Boucetta et al.   JOURNAL OF NEUROSCIENCE

Optogenetic Manipulation of Activity and Temporally Controlled Cell-Specific Ablation Reveal a Role for MCH Neurons in Sleep/Wake Regulation

(2014) T. Tsunematsu et al.   JOURNAL OF NEUROSCIENCE

Optogenetic-Mediated Release of Histamine Reveals Distal and Autoregulatory Mechanisms for Controlling Arousal

(2014) R. H. Williams et al.   JOURNAL OF NEUROSCIENCE

Meta-Analysis of Melanin-Concentrating Hormone Signaling-Deficient Mice on Behavioral and Metabolic Phenotypes

(2014) Kenkichi Takase et al.   PLoS One

Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep

(2014) Christa J. Van Dort et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coreleased Orexin and Glutamate Evoke Nonredundant Spike Outputs and Computations in Histamine Neurons

(2014) Cornelia Schöne et al.   Cell Reports

Long-lasting silencing of orexin/hypocretin neurons using archaerhodopsin induces slow-wave sleep in mice

(2013) Tomomi Tsunematsu et al.   BEHAVIOURAL BRAIN RESEARCH

Glutamatergic Signaling from the Parabrachial Nucleus Plays a Critical Role in Hypercapnic Arousal

(2013) S. Kaur et al.   JOURNAL OF NEUROSCIENCE

Optogenetic Stimulation of MCH Neurons Increases Sleep

(2013) R. R. Konadhode et al.   JOURNAL OF NEUROSCIENCE

Optogenetic identification of a rapid eye movement sleep modulatory circuit in the hypothalamus

(2013) Sonia Jego et al.   NATURE NEUROSCIENCE

Sleep and the single neuron: the role of global slow oscillations in individual cell rest

(2013) Vladyslav V. Vyazovskiy et al.   NATURE REVIEWS NEUROSCIENCE

Sleep Spindles

(2013) Anita Lüthi   NEUROSCIENTIST

Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction

(2013) Ashley M. Blouin et al.   Nature Communications

Functional wiring of hypocretin and LC-NE neurons: implications for arousal

(2013) Matthew E. Carter et al.   Frontiers in Behavioral Neuroscience

Optogenetic Probing of Fast Glutamatergic Transmission from Hypocretin/Orexin to Histamine Neurons In Situ

(2012) C. Schone et al.   JOURNAL OF NEUROSCIENCE

Mechanism for Hypocretin-mediated sleep-to-wake transitions

(2012) M. E. Carter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute Optogenetic Silencing of Orexin/Hypocretin Neurons Induces Slow-Wave Sleep in Mice

(2011) T. Tsunematsu et al.   JOURNAL OF NEUROSCIENCE

Regional Slow Waves and Spindles in Human Sleep

(2011) Yuval Nir et al.   NEURON

Pharmacogenetic Modulation of Orexin Neurons Alters Sleep/Wakefulness States in Mice

(2011) Koh Sasaki et al.   PLoS One

Enhancement of Synchronization Between Hippocampal and Amygdala Theta Waves Associated With Pontine Wave Density

(2010) Akihiro Karashima et al.   JOURNAL OF NEUROPHYSIOLOGY

Essential Role of Dopamine D2 Receptor in the Maintenance of Wakefulness, But Not in Homeostatic Regulation of Sleep, in Mice

(2010) W.-M. Qu et al.   JOURNAL OF NEUROSCIENCE

Direct Innervation and Modulation of Orexin Neurons by Lateral Hypothalamic LepRb Neurons

(2010) G. W. Louis et al.   JOURNAL OF NEUROSCIENCE

Tuning arousal with optogenetic modulation of locus coeruleus neurons

(2010) Matthew E Carter et al.   NATURE NEUROSCIENCE

Sleep State Switching

(2010) Clifford B. Saper et al.   NEURON

GABAergic regulation of the perifornical–lateral hypothalamic neurons during non-rapid eye movement sleep in rats

(2010) M.N. Alam et al.   NEUROSCIENCE

Cellular and chemical neuroscience of mammalian sleep

(2010) Subimal Datta   SLEEP MEDICINE

Behavioral phenotyping of Neuropeptide S receptor knockout mice

(2009) Dee M. Duangdao et al.   BEHAVIOURAL BRAIN RESEARCH

Orexin/Hypocretin and Histamine: Distinct Roles in the Control of Wakefulness Demonstrated Using Knock-Out Mouse Models

(2009) C. Anaclet et al.   JOURNAL OF NEUROSCIENCE

Sleep Homeostasis Modulates Hypocretin-Mediated Sleep-to-Wake Transitions

(2009) M. E. Carter et al.   JOURNAL OF NEUROSCIENCE

Activity Profiles of Cholinergic and Intermingled GABAergic and Putative Glutamatergic Neurons in the Pontomesencephalic Tegmentum of Urethane-Anesthetized Rats

(2009) S. Boucetta et al.   JOURNAL OF NEUROSCIENCE

Discharge Profiles of Identified GABAergic in Comparison to Cholinergic and Putative Glutamatergic Basal Forebrain Neurons across the Sleep-Wake Cycle

(2009) O. K. Hassani et al.   JOURNAL OF NEUROSCIENCE

Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep-wake cycle

(2009) O. K. Hassani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute administration of leptin produces anxiolytic-like effects: a comparison with fluoxetine

(2009) Jing Liu et al.   PSYCHOPHARMACOLOGY

Hypothalamic Regulation of Sleep and Arousal

(2008) Ronald Szymusiak et al.   Annals of the New York Academy of Sciences

Projections from basal forebrain to prefrontal cortex comprise cholinergic, GABAergic and glutamatergic inputs to pyramidal cells or interneurons

(2008) Pablo Henny et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Sleep architecture of the melanin-concentrating hormone receptor 1-knockout mice

(2008) Antoine Adamantidis et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Effects of Ibotenate and 192IgG-Saporin Lesions of the Nucleus Basalis Magnocellularis/Substantia Innominata on Spontaneous Sleep and Wake States and on Recovery Sleep after Sleep Deprivation in Rats

(2008) S. Kaur et al.   JOURNAL OF NEUROSCIENCE

Regulation of Synaptic Efficacy in Hypocretin/Orexin-Containing Neurons by Melanin Concentrating Hormone in the Lateral Hypothalamus

(2008) Y. Rao et al.   JOURNAL OF NEUROSCIENCE

Neuropeptide S-Mediated Control of Fear Expression and Extinction: Role of Intercalated GABAergic Neurons in the Amygdala

(2008) Kay Jüngling et al.   NEURON

The role of cholinergic basal forebrain neurons in adenosine-mediated homeostatic control of sleep: Lessons from 192 IgG–saporin lesions

(2008) A.V. Kalinchuk et al.   NEUROSCIENCE

Abnormal response of melanin-concentrating hormone deficient mice to fasting: Hyperactivity and rapid eye movement sleep suppression

(2008) J.T. Willie et al.   NEUROSCIENCE

Neuronal activity of orexin and non-orexin waking-active neurons during wake–sleep states in the mouse

(2008) K. Takahashi et al.   NEUROSCIENCE

Is Sleep Essential?

(2008) Chiara Cirelli et al.   PLOS BIOLOGY

Blocking melanin-concentrating hormone MCH1 receptor affects rat sleep–wake architecture

(2007) Abdellah Ahnaou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY