Article
Biochemistry & Molecular Biology
Joyce Dos Reis Lima, Maria Kueirislene Amancio Ferreira, Ketelly Vanessa Barros Sales, Antonio Wlisses da Silva, Emanuelle Machado Marinho, Francisco Ernani Alves Magalhaes, Emmanuel Silva Marinho, Marcia Machado Marinho, Matheus Nunes da Rocha, Paulo Nogueira Bandeira, Alexandre Magno Rodrigues Teixeira, Jane Eire Silva Alencar de Menezes, Helcio Silva dos Santos
Summary: This study evaluated the anxiolytic potential of the clerodine-type diterpene CBWS isolated from Croton blanchetianus in adult zebrafish. The results indicated that CBWS has anxiolytic effects mediated by serotonergic and anti-acetylcholinesterase actions. The study also suggested the involvement of 5-HTR1 and 5-HTR2A/2C receptors in the low anticonvulsant effect of CBWS.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Pharmacology & Pharmacy
Yi Jiang, Jie Zhou, Bai-Lin Song, Yan Wang, Dong-Lin Zhang, Zheng-Tian Zhang, Lai-Fu Li, Ying-Juan Liu
Summary: Social animals self-organize into dominance hierarchies, influenced by the serotonin system in the amygdala. This study explores the role of different 5-HT receptor subtypes in social rank determination and reveals their involvement in the formation and modulation of social hierarchy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Behavioral Sciences
Amin Charousaei, Mohammad Nasehi, Vahab Babapour, Salar Vaseghi, Mohammad-Reza Zarrindast
Summary: The study demonstrated the involvement of CA3 5-HT4 receptors in D-AP5-induced anxiolytic-like behaviors in rats. Specifically, the experimental results showed that these receptors play an important role in modulating anxiety-related behaviors in rats.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Medicine, Research & Experimental
Tia A. Griffith, Jake S. Russell, Saba Naghipour, Tessa J. Helman, Jason N. Peart, Nicolas J. C. Stapelberg, John P. Headrick, Eugene F. Du Toit
Summary: This study found that mice with type 2 diabetes (T2D) exhibited anxiety-like behavior, which was independent of body weight and blood glucose levels but may be related to resistance to leptin. Dietary n-3 polyunsaturated fatty acid (PUFA) did not show significant metabolic or behavioral benefits in T2D mice.
Article
Psychiatry
Chad Smith, Kyle J. Trageser, Henry Wu, Francis J. Herman, Umar Haris Iqbal, Maria Sebastian-Valverde, Tal Frolinger, Emma Zeng, Giulio Maria Pasinetti
Summary: Research on the impact of sleep deprivation on anxiety and anxiolytic properties reveals that a flavanol-rich dietary preparation can alleviate neuroimmune activation and reduce anxiety. Additionally, the study found that sleep deprivation alters the expression of circadian genes, leading to changes in NLRP3 expression and IL-1 beta production.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Pharmacology & Pharmacy
Florence Netzer, Caroline Sevoz-Couche
Summary: The rostral cuneiform nucleus participates in the defense inhibition of baroreflex bradycardia by activating LPGi and projecting to raphe magnus to activate NTS 5-HT3 receptors, providing new insights into the primary and secondary mechanisms involved in vital baroreflex prevention during stress.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Gabriela Belen Martinez-Hernandez, Enrique Jimenez-Ferrer, Manases Gonzalez-Cortazar, Ruben Roman-Ramos, Jaime Tortoriello, Gabriela Vargas-Villa, Maribel Herrera-Ruiz
Summary: Salvia elegans, a plant with biological activities in central nervous system, was studied for its anxiolytic and antidepressant effects. Fractions and compounds isolated from the plant were evaluated in mice, showing that TM and OA have antidepressant and anxiolytic properties and can interact with serotoninergic drugs.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
I Erkizia-Santamaria, R. Alles-Pascual, I Horrillo, J. J. Meana, J. E. Ortega
Summary: The study found that psilocin showed similar affinities for 5HT2AR, 5HT2CR, and 5HT1AR in both human and mice brain. Psilocybin induced a dose-dependent head-twitch response (HTR) and affected body temperature, which were both mediated by 5HT2AR, 5HT2CR, and 5HT1AR. These findings provide key insights into the mechanism of action of psilocybin and its therapeutic effects.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Yixiao Luo, Rafi Ullah, Jinfeng Wang, Yuru Du, Shihao Huang, Li Meng, Yuan Gao, Miao Gong, Ewa Galaj, Xi Yin, Haishui Shi
Summary: The study demonstrated that carbon monoxide (CO) has significant antidepressant and anxiolytic effects, providing protection through activation of HO-1 and exogenous CO administration. This research revealed a novel function of the HO-1/CO system, offering a promising therapeutic target for the treatment of depression and anxiety.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Yongxiang Li, Shuqing Zhu, Kailai Xie, Xiajie Feng, Lvshuang Chen, Xin Wu, Zhonghua Sun, Gang Shu, Songbo Wang, Canjun Zhu, Ping Gao, Qingyan Jiang, Lina Wang
Summary: TLR4 expressed in Tph2 neurons in the DRN can modulate anxiety-like behaviors in a sex-dependent manner. Deletion of TLR4 in Tph2 neurons or selective ablation of TLR4 in the DRN can decrease anxiety-like behaviors in male mice. Inhibition of TLR4 in the DRN can also reverse anxiety-like behavior induced by chronic immobilization stress.
Article
Computer Science, Artificial Intelligence
Ai-bing Ji, Jin-jin Zhang, Xing He, Yu-hang Zhang
Summary: This paper introduces the construction and parameter estimation methods of panel interval-valued data regression models, and applies them to the prediction of the Air Quality Index. Experimental results show that the proposed models have advantages and good performance.
KNOWLEDGE-BASED SYSTEMS
(2022)
Article
Biochemistry & Molecular Biology
Tatiana Rodrigues Garcia, Paulo De Tarso Cavalcante Freire, Antonio Wlisses da Silva, Maria Kueirislene Amancio Ferreira, Emanuela de Lima Reboucas, Francisco Rogenio Silva Mendes, Emanuelle Machado Marinho, Marcia Machado Marinho, Alexandre Magno Rodrigues Teixeira, Emmanuel Silva Marinho, Paulo Nogueira Bandeira, Jane Eire Silva Alencar de Menezes, Helcio Silva dos Santos
Summary: Anxiety and epilepsy are worldwide health concerns, and the current treatments using Benzodiazepines have serious side effects. Therefore, the discovery of new drugs for these conditions is necessary. This study evaluated the anxiolytic and anticonvulsant effects of an ibuprofen derivative (IBUACT) in adult Zebrafish and its interaction with the GABAergic receptor through virtual studies. The results showed that IBUACT exhibited similar anxiolytic behavior to Diazepam, and it delayed PTZ-induced seizures. Additionally, IBUACT strongly bound in the Diazepam region of GABA(A). This study also highlighted the potential pharmacological applications of ibuprofen derivatives in central nervous system pathologies.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Food Science & Technology
Xiping Zhu, Dongxiao Sun-Waterhouse, Chun Cui
Summary: The study demonstrated that the RPFE formula could reverse behavioral dysfunctions and body weight gain induced by chronic stress, normalize inflammatory cytokines and oxidative stress markers, as well as relieve hippocampal neuronal injury. The enhanced serotonin levels in the hippocampus may be attributed to serotonergic activation mediated by anti-inflammatory and antioxidant actions.
FOOD SCIENCE AND HUMAN WELLNESS
(2021)
Article
Food Science & Technology
Lourdes Santiago-Lopez, Arantxa Almada-Corral, Hugo S. Garcia, Veronica Mata-Haro, Aaron F. Gonzalez-Cordova, Belinda Vallejo-Cordoba, Adrian Hernandez-Mendoza
Summary: This study aimed to assess the potential antidepressant- and anxiolytic-like effects of huauzontle fermented by Lactiplantibacillus plantarum Lp22. The results showed that mice receiving both fermented and unfermented huauzontle exhibited more brave and active behaviors in the behavioral tests, and had lower oxidative stress index. These findings suggest the potential therapeutic applications of fermented huauzontle on depression and anxiety-like behaviors, possibly mediated by antioxidant and anti-inflammatory mechanisms.
Article
Immunology
Zhi-Heng Zheng, Xing-Cheng Lin, Ying Lu, Shi-Rui Cao, Xu-Kai Liu, Dong Lin, Fan-Hua Yang, Yang -Bo Zhang, Ping Hu, Wen-Hua Zhang
Summary: Increasing evidence suggests that immune system alterations contribute to the development of anxiety disorders, and inhibiting neuroinflammation may be an effective therapeutic strategy. Harmine, a compound found in medicinal plants, has been reported to have anti-inflammatory and potential anxiolytic effects. However, the mechanisms underlying these effects are not fully understood. This study showed that harmine alleviates anxiety-like behaviors by reducing neuroinflammation and restoring neuronal plasticity in the basolateral amygdala.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Susan M. Tyree, Luis de Lecea
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Review
Multidisciplinary Sciences
Neil McNaughton
JOURNAL OF THE ROYAL SOCIETY OF NEW ZEALAND
(2018)
Article
Behavioral Sciences
Jonas Toele, Antje Stolzenburg, Susan M. Tyree, Frauke Staehler, Wolfgang Meyerhof
Article
Neurosciences
Katharina Ulrich, Megg J. Spriggs, Wickliffe C. Abraham, John C. Dalrymple-Alford, Neil McNaughton
Review
Neurosciences
Carlos Silva, Neil McNaughton
PROGRESS IN NEUROBIOLOGY
(2019)
Editorial Material
Psychology, Biological
Neil McNaughton
NATURE HUMAN BEHAVIOUR
(2019)
Article
Neurosciences
Robert G. K. Munn, Caitlin S. Mallory, Kiah Hardcastle, Dane M. Chetkovich, Lisa M. Giocomo
NATURE NEUROSCIENCE
(2020)
Article
Neurosciences
Robert G. K. Munn, Lisa M. Giocomo
CURRENT OPINION IN NEUROBIOLOGY
(2020)
Article
Neurosciences
R. G. K. Munn, A. Freeburn, D. P. Finn, H. C. Heller
Summary: Down Syndrome is a genetic condition caused by trisomy 21, leading to difficulties in learning and memory. The hippocampus has been found to play a key role in learning and memory, and recent research with mouse models of Down Syndrome has shown differences in hippocampal activity. Excess GABAergic innervation from the Medial Septum to the hippocampus is thought to be one of the main functional differences in Down Syndrome. In this study, the activity of region CA1 in the hippocampus was examined in Ts65Dn mice compared to their non-trisomic 2N littermates using in vivo electrophysiology. While the spatial properties of place cells in CA1 were normal in Ts65Dn mice, there were profound alterations in the phasic relationship of both CA1 place cells and gamma rhythms to theta rhythm. These findings suggest that the overall network state of the hippocampus is critically important for its function and provide further evidence for excess inhibitory control as the cause of hippocampal dysfunction in Down Syndrome.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Cell Biology
Mahshid H. Dehkordi, Robert G. K. Munn, Howard O. Fearnhead
Summary: Caspases are a family of proteases that play crucial roles in cell death processes, particularly apoptosis. However, they are also involved in various non-apoptotic processes, especially in regulating neuronal cell behaviors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biology
Susan M. Tyree, Kimberly J. Jennings, Oscar C. Gonzalez, Shi-bin Li, Janet R. Nicholson, Moritz von Heimendahl, Luis de Lecea
Summary: Neurons expressing Hypocretin in the lateral hypothalamus are crucial for regulating arousal stability. This study investigates the dynamics of Hypocretin neuronal circuit during stop action impulsivity in mice performing a Go/NoGo task. The findings suggest that Hypocretin neurons play a key role in integrating salient stimuli to produce appropriate responses to rewarding and aversive cues.
COMMUNICATIONS BIOLOGY
(2023)
Article
Neurosciences
Robert G. K. Munn, Amy Wolff, Lucinda J. Speers, David K. Bilkey
Summary: Maternal immune activation (MIA) increases the risk for schizophrenia and other neurodevelopmental disorders. In rat models, MIA mimics the brain and behavioral changes seen in schizophrenia, including memory impairment. This study re-analyzed previous electrophysiological recordings of the hippocampus in MIA and control rats to investigate temporal dysfunction. The findings suggest abnormal gamma power and coherence, altered phase precession of place cells, and an increase in sharp-wave ripple events in the hippocampus of MIA rats, highlighting circuit-level changes that may contribute to information processing deficits in schizophrenia.
Review
Neurosciences
Susan M. Tyree, Luis de Lecea
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2017)
Review
Behavioral Sciences
Neil McNaughton, Philip J. Corr
CURRENT OPINION IN BEHAVIORAL SCIENCES
(2018)
Article
Behavioral Sciences
Amine Bahi
Summary: Gestational environmental enrichment (EE) has protective effects on social stress-induced anxiety-like behaviors and excessive ethanol consumption through increasing BDNF levels.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Sarabesh Natarajan, Grant Abass, Lucas Kim, Corinne Wells, Amir H. Rezvani, Edward D. Levin
Summary: Multiple neural systems, including dopamine D1 receptors and glutamate NMDA receptors, are involved in nicotine reinforcement. Acute blockade of D1 receptors decreases nicotine self-administration, while acute blockade of NMDA receptors increases it. Chronic blockade of NMDA receptors decreases nicotine self-administration. Memantine attenuates the decrease in nicotine self-administration caused by chronic D1 antagonist SCH-23390.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
David R. Maguire
Summary: The study found that Lorcaserin alone reduces ventilation and enhances the ventilatory-depressant effects of opioids. This suggests that combining a 5-HT2C receptor agonist with opioids may increase the risk of ventilatory depression without reducing abuse.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Fen Liu, Qing Tian, Hui-Ling Tang, Xiang Cheng, Wei Zou, Ping Zhang
Summary: This study demonstrates the attenuating effect of H2S on PD-associated depression by improving hippocampal synaptic plasticity.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Mehrsa Rahimi-Danesh, Mohammad-Ali Samizadeh, Amir-Ehsan Sajadi, Tara Rezvankhah, Salar Vaseghi
Summary: This study investigated the effects of lithium on freezing behavior and pain perception in a fear-conditioning model in rats. The results showed that lithium had no effect on freezing behavior and pain subthreshold in all rats. Extinction training decreased freezing behavior, with more efficacy in females. Gender differences were also observed in the effects of extinction training.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)