Translational Aspects of Sphingolipid Metabolism in Renal Disorders

Sphingomyelinase-like phosphodiesterase 3b mediates radiation-induced damage of renal podocytes

(2017) Anis Ahmad et al.   FASEB JOURNAL

Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome

(2017) Rathi Prasad et al.   JOURNAL OF CLINICAL INVESTIGATION

Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency

(2017) Svjetlana Lovric et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury

(2017) Tess V. Dupre et al.   JOURNAL OF LIPID RESEARCH

mTORC2 Signaling Regulates Nox4-Induced Podocyte Depletion in Diabetes

(2016) Stéphanie Eid et al.   ANTIOXIDANTS & REDOX SIGNALING

Podocyte injury and its consequences

(2016) Michio Nagata   KIDNEY INTERNATIONAL

CNS-accessible Inhibitor of Glucosylceramide Synthase for Substrate Reduction Therapy of Neuronopathic Gaucher Disease

(2016) John Marshall et al.   MOLECULAR THERAPY

Urinary Podocyte Loss Is Increased in Patients with Fabry Disease and Correlates with Clinical Severity of Fabry Nephropathy

(2016) Brent Fall et al.   PLoS One

One Year of Enzyme Replacement Therapy Reduces Globotriaosylceramide Inclusions in Podocytes in Male Adult Patients with Fabry Disease

(2016) Behzad Najafian et al.   PLoS One

Podocyte injury and repair mechanisms

(2015) Francesco Cellesi et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Lyso-Gb3 activates Notch1 in human podocytes

(2015) Maria D. Sanchez-Niño et al.   HUMAN MOLECULAR GENETICS

Reduced Activity of Sphingosine-1-Phosphate Lyase Induces Podocyte-related Glomerular Proteinuria, Skin Irritation, and Platelet Activation

(2015) Jens Schümann et al.   TOXICOLOGIC PATHOLOGY

Lysophosphatidylinositol: a novel link between ABC transporters and G-protein-coupled receptors

(2014) Emily L. Ruban et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Sphingosine-1-phosphate induces differentiation of cultured renal tubular epithelial cells under Rho kinase activation via the S1P2 receptor

(2014) Sho Ishizawa et al.   Clinical and Experimental Nephrology

Eliglustat tartrate

(2014) J.A. Shayman   DRUGS OF THE FUTURE

Orally Active 7-Substituted (4-Benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as Active-Site Inhibitors of Sphingosine 1-Phosphate Lyase for the Treatment of Multiple Sclerosis

(2014) Sven Weiler et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sphingomyelinase-Like Phosphodiesterase 3b Expression Levels Determine Podocyte Injury Phenotypes in Glomerular Disease

(2014) T.-H. Yoo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Therapeutic approaches to diabetic nephropathy—beyond the RAS

(2014) Beatriz Fernandez-Fernandez et al.   Nature Reviews Nephrology

Podocyte Pathology and Nephropathy – Sphingolipids in Glomerular Diseases

(2014) Sandra Merscher et al.   Frontiers in Endocrinology

Cyclodextrin Protects Podocytes in Diabetic Kidney Disease

(2013) S. Merscher-Gomez et al.   DIABETES

Characterization of eicosanoid synthesis in a genetic ablation model of ceramide kinase

(2013) Jennifer A. Mietla et al.   JOURNAL OF LIPID RESEARCH

Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids

(2013) Dhirendra K. Simanshu et al.   NATURE

Partial Deficiency of Sphingosine-1-Phosphate Lyase Confers Protection in Experimental Autoimmune Encephalomyelitis

(2013) Andreas Billich et al.   PLoS One

Dysregulated Autophagy Contributes to Podocyte Damage in Fabry’s Disease

(2013) Max C. Liebau et al.   PLoS One

GCS overexpression is associated with multidrug resistance of human HCT-8 colon cancer cells

(2012) Min Song et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Agalsidase Benefits Renal Histology in Young Patients with Fabry Disease

(2012) C. Tondel et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Circulating suPAR in Two Cohorts of Primary FSGS

(2012) C. Wei et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Fabry nephropathy: indications for screening and guidance for diagnosis and treatment by the European Renal Best Practice

(2012) Wim Terryn et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Acid Sphingomyelinase Gene Knockout Ameliorates Hyperhomocysteinemic Glomerular Injury in Mice Lacking Cystathionine-β-Synthase

(2012) Krishna M. Boini et al.   PLoS One

The Association Between Chronic Kidney Disease and Cardiovascular Disease Risk Factors in Atomic Bomb Survivors

(2012) Nobuko Sera et al.   RADIATION RESEARCH

Changes in the gene expression programs of renal mesangial cells during diabetic nephropathy

(2012) Eric W Brunskill et al.   BMC Nephrology

Acid Sphingomyelinase Gene Deficiency Ameliorates the Hyperhomocysteinemia-Induced Glomerular Injury in Mice

(2011) Krishna M. Boini et al.   AMERICAN JOURNAL OF PATHOLOGY

The effect of glucosylceramide synthase on P-glycoprotein function in K562/AO2 leukemia drug-resistance cell line

(2011) Yang-Yang Zhang et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Exogenous Ceramide-1-phosphate Reduces Lipopolysaccharide (LPS)-mediated Cytokine Expression

(2011) Jody L. Hankins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting glucosylceramide synthase sensitizes imatinib-resistant chronic myeloid leukemia cells via endogenous ceramide accumulation

(2011) Yusuf Baran et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Notch in the kidney: development and disease

(2011) Yasemin Sirin et al.   JOURNAL OF PATHOLOGY

Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes

(2011) Alaa S. Awad et al.   KIDNEY INTERNATIONAL

Rituximab Targets Podocytes in Recurrent Focal Segmental Glomerulosclerosis

(2011) A. Fornoni et al.   Science Translational Medicine

Co-suppression of MDR1 (multidrug resistance 1) and GCS（glucosylceramide synthase）restores sensitivity to multidrug resistance breast cancer cells by RNA interference (RNAi)

(2010) Xiaofang Zhang et al.   CANCER BIOLOGY & THERAPY

Insulin Signaling to the Glomerular Podocyte Is Critical for Normal Kidney Function

(2010) Gavin I. Welsh et al.   Cell Metabolism

Renal Atrophy Secondary to Chemoradiotherapy of Abdominal Malignancies

(2010) Gary Y. Yang et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Radiation-Associated Kidney Injury

(2010) Laura A. Dawson et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Mammalian ceramide synthases

(2010) Michal Levy et al.   IUBMB LIFE

Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans

(2010) Bernhard Bielesz et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of Sphingosine 1-Phosphate Lyase for the Treatment of Rheumatoid Arthritis: Discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-Tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone Oxime (LX2931) and (1R,2S,3R)-1-(2-(Isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932)

(2010) Jeffrey T. Bagdanoff et al.   JOURNAL OF MEDICINAL CHEMISTRY

NF- B in Renal Inflammation

(2010) A. B. Sanz et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Proteinuria, the Podocyte, and Insulin Resistance

(2010) Alessia Fornoni   NEW ENGLAND JOURNAL OF MEDICINE

Fabry disease

(2010) Dominique P Germain   Orphanet Journal of Rare Diseases

Rituximab: Mechanism of Action

(2010) George J. Weiner   SEMINARS IN HEMATOLOGY

Pharmacokinetic/pharmacodynamic modelling of 2-acetyl-4(5)-tetrahydroxybutyl imidazole-induced peripheral lymphocyte sequestration through increasing lymphoid sphingosine 1-phosphate

(2010) X. Q. Yu et al.   XENOBIOTICA

Specific podocin mutations determine age of onset of nephrotic syndrome all the way into adult life

(2009) Friedhelm Hildebrandt et al.   KIDNEY INTERNATIONAL

Incomplete Inhibition of Sphingosine 1-Phosphate Lyase Modulates Immune System Function yet Prevents Early Lethality and Non-Lymphoid Lesions

(2009) Peter Vogel et al.   PLoS One

Ceramide-enriched membrane domains—Structure and function

(2008) Yang Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Effects of ceramide and other simple sphingolipids on membrane lateral structure

(2008) Félix M. Goñi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Plasma Ceramides Are Elevated in Obese Subjects With Type 2 Diabetes and Correlate With the Severity of Insulin Resistance

(2008) J. M. Haus et al.   DIABETES

Contribution of Guanine Nucleotide Exchange Factor Vav2 to Hyperhomocysteinemic Glomerulosclerosis in Rats

(2008) Fan Yi et al.   HYPERTENSION

Failure to phosphorylate AKT in podocytes from mice with early diabetic nephropathy promotes cell death

(2008) T. Tejada et al.   KIDNEY INTERNATIONAL

The Notch pathway in podocytes plays a role in the development of glomerular disease

(2008) Thiruvur Niranjan et al.   NATURE MEDICINE

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nephropathy in males and females with Fabry disease: cross-sectional description of patients before treatment with enzyme replacement therapy

(2008) A. Ortiz et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Sphingolipids: players in the pathology of metabolic disease

(2008) L. Ashley Cowart   TRENDS IN ENDOCRINOLOGY AND METABOLISM