Natural Killer Cells: Angels and Devils for Immunotherapy

Preclinical targeting of aggressive T-cell malignancies using anti-CD5 chimeric antigen receptor

(2017) K H Chen et al.   LEUKEMIA

Cord blood NK cells engineered to express IL-15 and a CD19-targeted CAR show long-term persistence and potent antitumor activity

(2017) E Liu et al.   LEUKEMIA

Expression and Function of Granzymes A and B in Escherichia coli Peritonitis and Sepsis

(2017) M. Isabel García-Laorden et al.   MEDIATORS OF INFLAMMATION

The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2

(2017) Torsten Hartwig et al.   MOLECULAR CELL

Engineering Natural Killer Cells for Cancer Immunotherapy

(2017) Katayoun Rezvani et al.   MOLECULAR THERAPY

Increased expression of programmed cell death protein 1 on NK cells inhibits NK-cell-mediated anti-tumor function and indicates poor prognosis in digestive cancers

(2017) Y Liu et al.   ONCOGENE

Cryoablation combined with allogenic natural killer cell immunotherapy improves the curative effect in patients with advanced hepatocellular cancer

(2017) Mao Lin et al.   Oncotarget

CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response

(2017) Abdul S. Qadir et al.   Cell Reports

Granzyme A Contributes to Inflammatory Arthritis in Mice Through Stimulation of Osteoclastogenesis

(2017) Llipsy Santiago et al.   Arthritis & Rheumatology

Cytokine-Induced Killer Cells As Pharmacological Tools for Cancer Immunotherapy

(2017) Xingchun Gao et al.   Frontiers in Immunology

Natural Killer Group 2D Ligand Depletion Reconstitutes Natural Killer Cell Immunosurveillance of Head and Neck Squamous Cell Carcinoma

(2017) Sandra Weil et al.   Frontiers in Immunology

IL-15, TIM-3 and NK cells subsets predict responsiveness to anti-CTLA-4 treatment in melanoma patients

(2017) Rossana Tallerico et al.   OncoImmunology

Phase II Study of Haploidentical Natural Killer Cell Infusion for Treatment of Relapsed or Persistent Myeloid Malignancies Following Allogeneic Hematopoietic Cell Transplantation

(2016) Brian C. Shaffer et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Haploidentical Natural Killer Cells Infused before Allogeneic Stem Cell Transplantation for Myeloid Malignancies: A Phase I Trial

(2016) Dean A. Lee et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

T cells expressing an anti-B-cell maturation antigen chimeric antigen receptor cause remissions of multiple myeloma

(2016) S. A. Ali et al.   BLOOD

Cancer therapy in the necroptosis era

(2016) Z Su et al.   CELL DEATH AND DIFFERENTIATION

Larger Size of Donor Alloreactive NK Cell Repertoire Correlates with Better Response to NK Cell Immunotherapy in Elderly Acute Myeloid Leukemia Patients

(2016) A. Curti et al.   CLINICAL CANCER RESEARCH

Extracellular granzyme K mediates endothelial activation through the cleavage of protease-activated receptor-1

(2016) Mehul Sharma et al.   FEBS Journal

Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies

(2016) Marco Ruella et al.   JOURNAL OF CLINICAL INVESTIGATION

Granzymes A and B Regulate the Local Inflammatory Response during Klebsiella pneumoniae Pneumonia

(2016) M. Isabel García-Laorden et al.   Journal of Innate Immunity

IDH mutant gliomas escape natural killer cell immune surveillance by downregulation of NKG2D ligand expression

(2016) Xiaoran Zhang et al.   NEURO-ONCOLOGY

Antimicrobial Properties of an Immunomodulator - 15 kDa Human Granulysin

(2016) Hung-Mu Wei et al.   PLoS One

Phase I Study of Random Healthy Donor-Derived Allogeneic Natural Killer Cell Therapy in Patients with Malignant Lymphoma or Advanced Solid Tumors

(2016) Y. Yang et al.   Cancer Immunology Research

Novel treatment strategy with autologous activated and expanded natural killer cells plus anti-myeloma drugs for multiple myeloma

(2016) Alejandra Leivas et al.   OncoImmunology

Highly efficient IL-21 and feeder cell-driven ex vivo expansion of human NK cells with therapeutic activity in a xenograft mouse model of melanoma

(2016) Markus Granzin et al.   OncoImmunology

Targeting Ewing sarcoma with activated and GD2-specific chimeric antigen receptor-engineered human NK cells induces upregulation of immune-inhibitory HLA-G

(2016) Sareetha Kailayangiri et al.   OncoImmunology

Tunneling nanotubes mediate rescue of prematurely senescent endothelial cells by endothelial progenitors: exchange of lysosomal pool

(2016) Kaoru Yasuda et al.   Aging-US

Disialoganglioside-specific human natural killer cells are effective against drug-resistant neuroblastoma

(2015) Diana Seidel et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

A phase I/II trial of interleukin-15–stimulated natural killer cell infusion after haplo-identical stem cell transplantation for pediatric refractory solid tumors

(2015) Antonio Pérez-Martínez et al.   CYTOTHERAPY

Engineering NK Cells Modified With an EGFRvIII-specific Chimeric Antigen Receptor to Overexpress CXCR4 Improves Immunotherapy of CXCL12/SDF-1α-secreting Glioblastoma

(2015) Nadja Müller et al.   JOURNAL OF IMMUNOTHERAPY

Ex Vivo–expanded Natural Killer Cells Demonstrate Robust Proliferation In Vivo in High-risk Relapsed Multiple Myeloma Patients

(2015) Susann Szmania et al.   JOURNAL OF IMMUNOTHERAPY

ErbB2/HER2-Specific NK Cells for Targeted Therapy of Glioblastoma

(2015) Congcong Zhang et al.   JNCI-Journal of the National Cancer Institute

Targeting PD1–PDL1 immune checkpoint in plasmacytoid dendritic cell interactions with T cells, natural killer cells and multiple myeloma cells

(2015) A Ray et al.   LEUKEMIA

Selective Inhibition of Tumor Growth by Clonal NK Cells Expressing an ErbB2/HER2-Specific Chimeric Antigen Receptor

(2015) Kurt Schönfeld et al.   MOLECULAR THERAPY

Natural killer cell therapy in children with relapsed leukemia

(2015) Jeffrey E. Rubnitz et al.   PEDIATRIC BLOOD & CANCER

Clinical impact of the NKp30/B7-H6 axis in high-risk neuroblastoma patients

(2015) Michaela Semeraro et al.   Science Translational Medicine

Granzyme M expressed by tumor cells promotes chemoresistance and EMT in vitro and metastasis in vivo associated with STAT3 activation

(2015) Huiru Wang et al.   Oncotarget

ErbB2/HER2-Specific NK Cells for Targeted Therapy of Glioblastoma

(2015) Congcong Zhang et al.   JNCI-Journal of the National Cancer Institute

Dual targeting of glioblastoma with chimeric antigen receptor-engineered natural killer cells overcomes heterogeneity of target antigen expression and enhances antitumor activity and survival

(2015) Sabrina Genßler et al.   OncoImmunology

B7-H6-mediated downregulation of NKp30 in NK cells contributes to ovarian carcinoma immune escape

(2015) Silvia Pesce et al.   OncoImmunology

Two-Stage Priming of Allogeneic Natural Killer Cells for the Treatment of Patients with Acute Myeloid Leukemia: A Phase I Trial

(2015) Panagiotis D. Kottaridis et al.   PLoS One

Clearance of acute myeloid leukemia by haploidentical natural killer cells is improved using IL-2 diphtheria toxin fusion protein

(2014) V. Bachanova et al.   BLOOD

Transmissible cytotoxicity of multiple myeloma cells by cord blood-derived NK cells is mediated by vesicle trafficking

(2014) B Martin-Antonio et al.   CELL DEATH AND DIFFERENTIATION

Ovarian tumor-associated microRNA-20a decreases natural killer cell cytotoxicity by downregulating MICA/B expression

(2014) Jingyan Xie et al.   Cellular & Molecular Immunology

Macrophage Migration Inhibitory Factor Contributes to the Immune Escape of Ovarian Cancer by Down-Regulating NKG2D

(2014) M. Krockenberger et al.   JOURNAL OF IMMUNOLOGY

NK cells kill mycobacteria directly by releasing perforin and granulysin

(2014) Chia-Chen Lu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

(2014) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Expansion of NK Cells and Reduction of NKG2D Expression in Chronic Lymphocytic Leukemia. Correlation with Progressive Disease

(2014) Leticia Huergo-Zapico et al.   PLoS One

Granzyme K synergistically potentiates LPS-induced cytokine responses in human monocytes

(2014) A. C. Wensink et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NK cell intrinsic regulation of MIP-1α by granzyme M

(2014) N Baschuk et al.   Cell Death & Disease

Targeting CD20+ Aggressive B-cell Non-Hodgkin Lymphoma by Anti-CD20 CAR mRNA-Modified Expanded Natural Killer Cells In Vitro and in NSG Mice

(2014) Y. Chu et al.   Cancer Immunology Research

Crosstalk between apoptosis, necrosis and autophagy

(2013) Vassiliki Nikoletopoulou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Are all granzymes cytotoxic in vivo?

(2013) Lars T. Joeckel et al.   BIOLOGICAL CHEMISTRY

Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis

(2013) O Susanto et al.   CELL DEATH AND DIFFERENTIATION

CS1-specific chimeric antigen receptor (CAR)-engineered natural killer cells enhance in vitro and in vivo antitumor activity against human multiple myeloma

(2013) J Chu et al.   LEUKEMIA

Transfection of chimeric anti-CD138 gene enhances natural killer cell activation and killing of multiple myeloma cells

(2013) Hua Jiang et al.   Molecular Oncology

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

(2013) Stephan A. Grupp et al.   NEW ENGLAND JOURNAL OF MEDICINE

When Cells Become Organelle Donors

(2013) Robert S. Rogers et al.   PHYSIOLOGY

Antigen Presenting Cell-Mediated Expansion of Human Umbilical Cord Blood Yields Log-Scale Expansion of Natural Killer Cells with Anti-Myeloma Activity

(2013) Nina Shah et al.   PLoS One

Genetic and Environmental Determinants of Human NK Cell Diversity Revealed by Mass Cytometry

(2013) A. Horowitz et al.   Science Translational Medicine

A clinically adaptable method to enhance the cytotoxicity of natural killer cells against B-cell malignancies

(2012) Noriko Shimasaki et al.   CYTOTHERAPY

Human Cytomegalovirus (CMV)-Induced Memory-like NKG2C+ NK Cells Are Transplantable and Expand In Vivo in Response to Recipient CMV Antigen

(2012) B. Foley et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial transfer from bone-marrow–derived stromal cells to pulmonary alveoli protects against acute lung injury

(2012) Mohammad Naimul Islam et al.   NATURE MEDICINE

Membrane-Bound IL-21 Promotes Sustained Ex Vivo Proliferation of Human Natural Killer Cells

(2012) Cecele J. Denman et al.   PLoS One

Successful transfer of alloreactive haploidentical KIR ligand-mismatched natural killer cells after infusion in elderly high risk acute myeloid leukemia patients

(2011) A. Curti et al.   BLOOD

Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function

(2011) B. Foley et al.   BLOOD

Adoptive Transfer of Autologous Natural Killer Cells Leads to High Levels of Circulating Natural Killer Cells but Does Not Mediate Tumor Regression

(2011) M. R. Parkhurst et al.   CLINICAL CANCER RESEARCH

Granulysin Delivered by Cytotoxic Cells Damages Endoplasmic Reticulum and Activates Caspase-7 in Target Cells

(2011) R. V. Saini et al.   JOURNAL OF IMMUNOLOGY

Unexpected Role for Granzyme K in CD56bright NK Cell-Mediated Immunoregulation of Multiple Sclerosis

(2011) W. Jiang et al.   JOURNAL OF IMMUNOLOGY

Expansion of a unique CD57+NKG2Chi natural killer cell subset during acute human cytomegalovirus infection

(2011) S. Lopez-Verges et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elucidation of the integrin LFA-1-mediated signaling pathway of actin polarization in natural killer cells

(2010) E. M. Mace et al.   BLOOD

Donor selection for natural killer cell receptor genes leads to superior survival after unrelated transplantation for acute myelogenous leukemia

(2010) S. Cooley et al.   BLOOD

The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody

(2010) D. M. Benson et al.   BLOOD

Killer Ig-like receptor-mediated control of natural killer cell alloreactivity in haploidentical hematopoietic stem cell transplantation

(2010) L. Moretta et al.   BLOOD

Cell Death Mechanisms Induced by Cytotoxic Lymphocytes

(2010) L Chávez-Galán et al.   Cellular & Molecular Immunology

Activation of the JNK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on CXCR4 and CD74

(2010) Hongqi Lue et al.   CELLULAR SIGNALLING

Clinical-grade, large-scale, feeder-free expansion of highly active human natural killer cells for adoptive immunotherapy using an automated bioreactor

(2010) Tolga Sutlu et al.   CYTOTHERAPY

A phase II study of allogeneic natural killer cell therapy to treat patients with recurrent ovarian and breast cancer

(2010) Melissa A. Geller et al.   CYTOTHERAPY

NKAML: A Pilot Study to Determine the Safety and Feasibility of Haploidentical Natural Killer Cell Transplantation in Childhood Acute Myeloid Leukemia

(2010) Jeffrey E. Rubnitz et al.   JOURNAL OF CLINICAL ONCOLOGY

A Role for Granzyme M in TLR4-Driven Inflammation and Endotoxicosis

(2010) D. A. Anthony et al.   JOURNAL OF IMMUNOLOGY

Human Natural Killer Cells Exhibit Direct Activity Against Aspergillus fumigatus Hyphae, But Not Against Resting Conidia

(2010) Stanislaw Schmidt et al.   JOURNAL OF INFECTIOUS DISEASES

Cytolytic activity of NK cell clones against acute childhood precursor-B-cell leukaemia is influenced by HLA class I expression on blasts and the differential KIR phenotype of NK clones

(2009) T Feuchtinger et al.   BONE MARROW TRANSPLANTATION

Fifteen Years of Gene Therapy Based on Chimeric Antigen Receptors: “Are We Nearly There Yet?”

(2009) Gianpietro Dotti et al.   HUMAN GENE THERAPY

Safety analysis ofex vivo-expanded NK and NK-like T cells administered to cancer patients: a Phase I clinical study

(2009) Lisbeth Barkholt et al.   Immunotherapy

Ignition of p53 Bomb Sensitizes Tumor Cells to Granzyme K-Mediated Cytolysis

(2009) G. Hua et al.   JOURNAL OF IMMUNOLOGY

Endocytosis and Intracellular Trafficking of Human Natural Killer Cell Receptors

(2009) Madhan Masilamani et al.   TRAFFIC

Autologous antitumor activity by NK cells expanded from myeloma patients using GMP-compliant components

(2008) E. Alici et al.   BLOOD

Infusion of haplo-identical killer immunoglobulin-like receptor ligand mismatched NK cells for relapsed myeloma in the setting of autologous stem cell transplantation

(2008) Jumei Shi et al.   BRITISH JOURNAL OF HAEMATOLOGY

Up on the tightrope: natural killer cell activation and inhibition

(2008) Lewis L Lanier   NATURE IMMUNOLOGY