Article
Food Science & Technology
Yanmin Liang, Yaru Han, Jie Dan, Runli Li, Hao Sun, Jianlong Wang, Wentao Zhang
Summary: A stable and highly active SOD-like nanozyme (Cu-NMPs) with strong free radical scavenging capacity was constructed by functionalizing melanin nanoparticles (NMPs) with Cu2+. The nanozyme was embedded into carrageenan (Carr) films to prepare a composite film for food packaging. The composite film not only exhibited high activity and stability, but also extended the storage time of cherry tomatoes by more than 3 days.
FOOD RESEARCH INTERNATIONAL
(2023)
Review
Chemistry, Multidisciplinary
Wei Cao, Xuhao Zhou, Naneki C. McCallum, Ziying Hu, Qing Zhe Ni, Utkarsh Kapoor, Christian M. Heil, Kristine S. Cay, Tara Zand, Alex J. Mantanona, Arthi Jayaraman, Ali Dhinojwala, Dimitri D. Deheyn, Matthew D. Shawkey, Michael D. Burkart, Jeffrey D. Rinehart, Nathan C. Gianneschi
Summary: Melanin is a natural biomaterial with various functions found in living organisms, classified into different types based on chemical precursors. Despite its complexity and diversity in chemical structure, synthetic mimics have been used to study its structure-function relationships. Efforts are being made to elucidate biosynthetic pathways and characterize melanin materials for potential new opportunities in synthetic materials.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Biology
Juan Carlos Stockert, Alfonso Blaquez-Castro
Summary: Melanins are ancient and important natural macromolecular pigments with multiple biological roles. This review explores the chemical structure, molecular orbital features, and supramolecular organization of melanin, as well as its potential applications in photothermal and ultrasonic protocols for melanoma treatment.
Review
Biotechnology & Applied Microbiology
Nilesh Kolhe, Eeshan Damle, Aditya Pradhan, Smita Zinjarde
Summary: The non-conventional yeast Yarrowia lipolytica is a model organism used to study biological processes and for bioremediation purposes. This fungus has physiological and biochemical features that enable it to withstand stress induced by metal pollutants, making it a potential candidate for the bioremediation of metal-contaminated environments.
BIOTECHNOLOGY ADVANCES
(2022)
Article
Chemistry, Multidisciplinary
Ayala Lampel, Scott A. McPhee, Salma Kassem, Deborah Sementa, Tlalit Massarano, James M. Aramini, Ye He, Rein V. Ulijn
Summary: Melanin and related polyphenolic pigments are versatile functional polymers that play diverse aesthetic and protective roles in the living world. The properties of these structures are dictated by covalent and non-covalent interactions, and directing oxidative polymerization of their precursors remains a major challenge.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Materials Science, Ceramics
Olga A. Shilova, Anastasiya S. Kovalenko, Anton M. Nikolaev, Sergey Mjakin, Alexander A. Sinel'nikov, Vladimir P. Chelibanov, Yulia E. Gorshkova, Nataliya Tsvigun, Olim N. Ruzimuradov, Gennady P. Kopitsa
Summary: The surface of TiO2 nanoparticles was modified with silica prepared by acid hydrolysis, resulting in a twofold increase in specific surface area. The modification also changed the surface functionality from Lewis acidity to Brönsted acidity. The resulting TiO2@SiO2 core-shell particles exhibited significantly enhanced singlet oxygen generation and photocatalytic activity.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2023)
Article
Food Science & Technology
Fengpei Zhang, Fanzheng Xue, Hui Xu, Yuan Yuan, Xiaoping Wu, Junli Zhang, Junsheng Fu
Summary: The study found that the compound enzymatic method was the best way to extract IHFM, with the best solid medium formula being normal pH, rice 20 g per cultivation bottle, maltose 22 g/L, beef extract 4.4 g/L, carbon-nitrogen ratio 5:1, and liquid-to-material ratio 1.1:1, resulting in significantly improved yield of melanin.
Article
Engineering, Environmental
Yanlong Kong, Lei Zhou, Shiyang Liao, Changping Wang, Jing Chen, Xiaopan Cai, Shichang Zhao, Dianwen Song, Yadong Zhang
Summary: A bone-targeted nanotheranostic was designed to treat osteosarcoma, showing high photothermal efficiency and bone targeting affinity after optimization. This nanotherapy successfully inhibited bone destruction and tumor growth in an experimental animal model, providing a potential new treatment for osteosarcoma.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Ziyue Zu, Jie Sheng, Jianchen Qi, Yu Miao, Yunming Zhang, Tao Zheng, Kaiyan Xiang, Haoguang Wu, Guangming Lu, Longjiang Zhang
Summary: A novel biomedical application of natural polyphenol melanin as a therapeutic nanoplatform for atherosclerosis is reported. The use of melanin nanoparticles can effectively attenuate the development and improve the stability of atherosclerotic plaques. This study suggests the potential for using melanin to develop natural multifunctional nanoplatforms for molecular theranostic in atherosclerosis and other pyroptosis-related diseases.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Meijun Fu, Yuping Yang, Zhaomeng Zhang, Yaling He, Yuanyuan Wang, Chenxing Liu, Xiaohong Xu, Jing Lin, Fei Yan
Summary: Photothermal therapy (PTT) has gained attention due to its minimally invasive and spatiotemporally selective advantages. However, current PTT agents often require complex and environmentally hazardous fabrication procedures. This study presents a genetically engineered bacterium capable of synthesizing melanin nanoparticles under mild and environmentally friendly conditions. These biosynthetic melanin nanoparticles exhibit excellent biocompatibility, stability, and minimal toxicity. They also have a higher photothermal conversion efficiency than chemically synthesized melanin-like polydopamine nanoparticles. Additionally, the biosynthetic melanin nanoparticles show excellent performance in photoacoustic imaging (PAI) and can be used for PAI-guided PTT in vivo.
Article
Environmental Sciences
Mateja Potisek, Matevz Likar, Katarina Vogel-Mikus, Iztok Arcon, Joze Grdadolnik, Marjana Regvar
Summary: The study demonstrates the significant contribution of DHN melanin to Cd tolerance in dark septate endophytes, with higher melanisation leading to increased tolerance through immobilizing Cd to hydroxyl groups and maintaining the integrity of the fungal cell wall. Tricyclazole treatment altered the Cd ligand environment, suggesting a role of melanin-independent Cd tolerance mechanisms in less melanised DSE fungi.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Plant Sciences
Amina G. G. Daminova, Anna E. E. Rassabina, Venera R. R. Khabibrakhmanova, Richard P. P. Beckett, Farida V. V. Minibayeva
Summary: Lichens are extremophilic organisms with exceptional resistance to environmental factors, including UV irradiation. Melanization, through its binding with cell wall components, plays a crucial role in protecting lichens from UV-B stress. Our study found that melanin can bind with carbohydrates in the hyphal cell wall, particularly chitin and 1,4-β-glucans, resulting in the smoothing of the surface relief and thickening of cell walls in the melanized upper cortex of lichen thalli, which contribute to their survival under UV stress.
Article
Engineering, Biomedical
Chang Liu, Quan Zou, Huixin Tang, Jia Liu, Shiqi Zhang, Caihong Fan, Junwei Zhang, Ruiqing Liu, Yashan Liu, Ruiyan Liu, Yan Zhao, Qiang Wu, Zhi Qi, Yanna Shen
Summary: Myocardial injury in sepsis is a severe complication resulting in increased morbidity and mortality. Recent studies have shown that reactive oxygen species (ROS)-mediated ferroptosis plays a crucial role in the development of heart diseases. In this study, the researchers demonstrated that a small biocompatible and MRI-visible melanin nanoparticles (MMPP) can improve myocardial function by inhibiting the ROS-related ferroptosis signaling pathway. Through various experiments, they showed that MMPP alleviated myocardial injury, suppressed iron-accumulation induced ferroptosis, and protected against sepsis-induced cardiac injury. These findings suggest that MMPP could be a potential novel therapeutic approach in the future.
BIOACTIVE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Dipika Nandi, Manisha Shivrayan, Jingjing Gao, Jithu Krishna, Ritam Das, Bin Liu, S. Thayumanavan, Ashish Kulkarni
Summary: Designer nanomaterials capable of delivering immunomodulators to specific immune cells have been extensively studied, but certain nanomaterials can nonspecifically activate NLRP3 inflammasomes, leading to unwanted effects. Core hydrophobicity strongly activates NLRP3 assembly compared to other nanoparticle attributes. Different signaling pathways and kinetics are observed with varying core hydrophobicity patterns.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Sirun Yang, Dennis Larsen, Maria Pellegrini, Sebastian Meier, Dale F. Mierke, Sophie R. Beeren, Ivan Aprahamian
Summary: The high water solubility of gamma-cyclodextrin can lower synthetic yield and increase production costs, but a photoremovable hydrazone template has been shown to increase efficiency in enzymatic synthesis and reduce costs. The Z isomer of the hydrazone switch is preferentially included in gamma-CD, leading to a 6-fold increase in yield. This discovery may pave the way for designing adaptive materials based on gamma-CD.
Article
Chemistry, Applied
Arne A. Ruediger, Wolfgang Bremser, Oliver I. Strube
JOURNAL OF COATINGS TECHNOLOGY AND RESEARCH
(2016)
Article
Materials Science, Multidisciplinary
Oliver I. Strube, Anne Buengeler, Wolfgang Bremser
MACROMOLECULAR MATERIALS AND ENGINEERING
(2016)
Article
Materials Science, Multidisciplinary
Arne A. Ruediger, Wolfgang Bremser, Oliver I. Strube
MACROMOLECULAR MATERIALS AND ENGINEERING
(2016)
Article
Chemistry, Multidisciplinary
Anne Buengeler, Benjamin Haemisch, Klaus Huber, Wolfgang Bremser, Oliver I. Strube
Article
Polymer Science
Martin Wortmann, Natalie Frese, Alexander Heide, Johannes Brikmann, Oliver Strube, Raphael Dalpke, Armin Goelzhaeuser, Elmar Moritzer, Bruno Huesgen
POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING
(2018)
Article
Chemistry, Multidisciplinary
Arne A. Ruediger, Katharina Brassat, Joerg K. N. Lindner, Wolfgang Bremser, Oliver Strube
Article
Chemistry, Applied
Joerg Ressel, Oliver Seewald, Wolfgang Bremser, Hans-Peter Reicher, Oliver Strube
PROGRESS IN ORGANIC COATINGS
(2018)
Article
Materials Science, Multidisciplinary
Daniel Appel, David Wedegaertner, Marco Luether, Oliver I. Strube
MACROMOLECULAR MATERIALS AND ENGINEERING
(2019)
Article
Chemistry, Applied
Anne Buengeler, Dominik Hense, Oliver Strube
JOURNAL OF COATINGS TECHNOLOGY AND RESEARCH
(2019)
Article
Chemistry, Physical
David Wedegaertner, Oliver I. Strube
Article
Chemistry, Multidisciplinary
Benjamin Haemisch, Anne Buengeler, Charlotte Kielar, Adrian Keller, Oliver Strube, Klaus Huber
Article
Chemistry, Applied
Joerg Ressel, Oliver Seewald, Wolfgang Bremser, Hans-Peter Reicher, Oliver Strube
PROGRESS IN ORGANIC COATINGS
(2020)
Article
Biochemistry & Molecular Biology
Dominik Hense, Anne Buengeler, Fabian Kollmann, Marcel Hanke, Alejandro Orive, Adrian Keller, Guido Grundmeier, Klaus Huber, Oliver Strube
Summary: This study presents a novel method for self-assembling fibrinogen into 3D nanofibrous structures in solution, forming stable hydrogels upon interaction with specific anions in controlled environments; The hydrogels can be converted into aerogels through lyophilization, both of which have never been described before; The method offers a new potential solution for issues in fibrinogen material applications.
Article
Biochemistry & Molecular Biology
Anne Buengeler, Fabian Kollmann, Klaus Huber, Oliver Strube
Summary: Eumelanin possesses a well-defined supramolecular structure with at least three distinct particle species. In this study, a protocol for synthesizing pure and stable dispersion of intermediate type-A particles is presented. The aggregation of type-A particles into larger type-B variant can be prevented by strict pH control. The pH influence on the supramolecular buildup is investigated using various techniques. The results demonstrate that it is possible to inhibit the aggregation of eumelanin substructures and access them in the form of a stable dispersion.
