Article
Infectious Diseases
Hanif Haidari, Zlatko Kopecki, Adam T. Sutton, Sanjay Garg, Allison J. Cowin, Krasimir Vasilev
Summary: A sensitive pH-responsive hydrogel has been developed for on-demand release of silver nanoparticles to effectively eliminate both Gram-negative and positive bacteria in infected wounds. The hydrogel shows potential as a promising new material for wound treatment with no toxicity towards mammalian skin cells.
Article
Biochemistry & Molecular Biology
Xiaosu Huang, Junhua Yang, Renyue Zhang, Lianbao Ye, Ming Li, Weiqiang Chen
Summary: Globally, wound infection, particularly bacterial infections like MRSA, poses a significant healthcare challenge. This study demonstrates that PD hydrogel may be a safe and effective treatment option for MRSA-infected wounds, improving wound healing, reducing inflammation, and decreasing bacterial load.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Biomaterials
Siyao Lv, Xulin Jiang
Summary: A series of novel biodegradable films based on thermosensitive carboxymethyl chitin were prepared, with LTCF-5 film showing the best mechanical strength and slow release of silver ions, exhibiting long-lasting antibacterial activity in vitro and potential for infected wound healing.
BIOMATERIALS SCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Wenshang Zhang, Bingjie Wang, Guangli Xiang, Tianze Jiang, Xia Zhao
Summary: To enhance the healing of infected wounds without using antibiotics, a new strategy combining zinc-metal-organic framework (MOF) with photodynamic therapy (PDT) was developed. The strategy involved using a Chlorin e6 (Ce6)-loaded zinc-MOF hydrogel (Ce6@MOF-Gel) to release Ce6 in an acid-responsive manner, improving antibacterial effects and promoting wound healing. The Ce6@MOF-Gel showed enhanced stability, solubility, and photodynamic properties of Ce6, reducing inflammation and facilitating collagen deposition and re-epithelialization for accelerated healing.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Aditya K. Kar, Amrita Singh, Divya Singh, Nikita Shraogi, Rahul Verma, Joel Saji, Pankaj Jagdale, Debabrata Ghosh, Satyakam Patnaik
Summary: A Guar Gum-based macroporous hydrogel infused with antibacterial agent and antioxidant can promote wound healing and inhibit bone infection in a high-fat-diet-induced diabetes mice model. The hydrogel facilitates scar-free wound healing through enhanced cell proliferation, tissue fiber formation, void space reduction, and re-epithelialization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Ghassan H. Matar, Muberra Andac
Summary: Silver nanoparticles-loaded locust bean gum/polyvinyl alcohol hydrogels with promising antibacterial properties were successfully prepared and characterized. The hydrogels exhibited good antibacterial activity against Gram-negative and Gram-positive bacteria, as confirmed through various characterization techniques. The results suggest that these hydrogels could be a potential candidate for medical applications due to their effective antibacterial properties.
Article
Microbiology
Gandhimathi Chinnasamy, Smitha Chandrasekharan, Tong Wey Koh, Somika Bhatnagar
Summary: The study presented a green synthesis route to produce AI-AgNPs with enhanced antibacterial and free-radical scavenging efficacy. The biocompatibility and antibacterial properties of AI-AgNPs were confirmed through various experiments, highlighting their potential use in wound healing applications.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Chemistry, Physical
Shaista Bano, Muhammad Hasnain, Khadija Rehman, Tasmina Kanwal, Samina Perveen, Saira Aziz, Saira Yasmeen, Sabira Begum, Bina Siddique, Muhammad Raza Shah
Summary: This study focuses on the green synthesis of silver nanoparticles stabilized by gum Arabic as a nano-carrier for quercitrin, which was subsequently modified with casein and polydopamine to improve its antimicrobial potential against S. aureus. The synthesized nanoparticles were characterized using various techniques, and the results showed that the polydopamine-modified nanoparticles exhibited a stronger antibacterial effect against S. aureus. Therefore, this study is of great importance for enhancing the antibacterial ability of quercitrin.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Polymer Science
Nafise Amiri, Sahand Ghaffari, Ida Hassanpour, Taesik Chae, Reza Jalili, Ruhangiz Taghi Kilani, Frank Ko, Aziz Ghahary, Dirk Lange
Summary: A silver nanoparticle-based hydrogel composite has been created to prevent infection, promote tissue repair, and fill cavities in wounds that are difficult to reach with other dressings.
Article
Engineering, Environmental
Meng Li, Yongping Liang, Yuqing Liang, Guoying Pan, Baolin Guo
Summary: Researchers have developed an injectable adhesive self-healing photothermal hydrogel that can adapt to frequent movement wounds and promote healing, while also preventing and treating wound infections.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Biomedical
Qiankun Zeng, Yuna Qian, Yijing Huang, Feng Ding, Xiaoliang Qi, Jianliang Shen
Summary: A nanocomposite hydrogel XKP was developed for skin wound healing, featuring high elasticity and tunable water content to adapt to wound shape. The embedded PDA NPs act as photothermal transduction agents to trigger bacterial death, accelerating wound healing significantly by reducing inflammation and promoting vascular reconstruction.
BIOACTIVE MATERIALS
(2021)
Article
Chemistry, Applied
Yan Wang, Mingrui Yang, Zheng Zhao
Summary: A novel hydrogen-bonded polysaccharide hydrogel consisting of cationic guar gum and CuCl2 was developed, which exhibited self-healing, injectable, and self-adapting properties. The hydrogel showed good mechanical strength, biocompatibility, antibacterial ability, and complete degradation in vivo. This study provides a simple and straightforward strategy for preparing self-healing polysaccharide hydrogels based on hydrogen bonding, expanding their applications in biomedicine and tissue regeneration.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Applied
Lisheng Zhou, Liming Zhou, Chengxiu Wei, Rui Guo
Summary: A dextran-based hydrogel loaded with black phosphorus nanosheets and zinc oxide nanoparticles exhibits synergistic antibacterial activity and reduces macrophage polarization, promoting the healing of infected wounds.
CARBOHYDRATE POLYMERS
(2022)
Article
Materials Science, Multidisciplinary
Werner E. G. Mueller, Hadrian Schepler, Meik Neufurth, Shunfeng Wang, Veronica Ferrucci, Massimo Zollo, Rongwei Tan, Heinz C. Schroeder, Xiaohong Wang
Summary: The polyP hydrogel formulation can accelerate the healing of chronic wounds and provide more metabolic energy by encapsulating and killing bacteria.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Armin Amirsadeghi, Arman Jafari, Seyyedeh-Sara Hashemi, Aboozar Kazemi, Younes Ghasemi, Amin Derakhshanfar, Mohammad-Ali Shahbazi, Seyyed Vahid Niknezhad
Summary: Novel sprayable antibacterial dressings were developed by in-situ formation of Ag-nanoparticles using Persian gum as a carbohydrate polymer. The dressings showed good sprayability, antibacterial activity, and biocompatibility, indicating high potential for wound repair.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Chemistry, Analytical
Pedro Carneiro, Joana A. Loureiro, Cristina Delerue-Matos, Simone Morais, Maria do Carmo Pereira
Summary: In this study, a sensitive and specific electrochemical immunosensor was developed for the detection and quantification of alpha-synuclein, a biomarker for Parkinson's disease. The immunosensor is based on voltammetric study and uses antibodies to recognize the analyte. The sensor is nanostructured using a layer-by-layer approach and has shown excellent detection capabilities within a certain concentration range.
Article
Chemistry, Multidisciplinary
Juliana Lima Nascimento, Angelica Gomes Coelho, Ytallo Samuel Oliveira Barros, Irisdalva Sousa Oliveira, Francilene Vieira da Silva, Ana Flavia Seraine Custodio Viana, Bruno Quirino Araujo, Marcio dos Santos Rocha, Francisco das Chagas Pereira de Andrade, Celma de Oliveira Barbosa, Helio de Barros Fernandes, Anderson Nogueira Mendes, Joaquim Soares da Costa-Junior, Rita de Cassia Meneses Oliveira, Massimo Lucarini, Alessandra Durazzo, Daniel Dias Rufino Arcanjo, Antonia Maria das Gracas Lopes Cito
Summary: Bacuri, a native plant of Brazil, has antioxidant activity against free radicals. In this study, an inclusion complex of beta-cyclodextrin (beta-CD) with the hexanic extract of bacuri seeds (BSHE) was produced, characterized and evaluated for its gastroprotective effect. The inclusion complex showed enhanced gastroprotective activity, indicating the potential use of this formulation in the treatment of peptic ulcers.
APPLIED SCIENCES-BASEL
(2023)
Article
Food Science & Technology
Diana Pinto, Manuela M. Moreira, Elsa F. Vieira, Jaroslava Svarc-Gajic, Anna Vallverdu-Queralt, Tanja Brezo-Borjan, Cristina Delerue-Matos, Francisca Rodrigues
Summary: Functional cookies made from Chestnut (Castanea sativa) shells (CSs) extract show good nutritional composition, high phenolic and flavonoid contents, excellent antioxidant and antiradical activities, and great sensory evaluation. This study encourages the sustainable recovery of antioxidants from CSs and their further use as active nutraceutical ingredients in functional cookies.
Article
Environmental Sciences
Juliana Guimaraes, Isabella Bracchi, Catia Pinheiro, Nara Xavier Moreira, Claudia Matta Coelho, Diogo Pestana, Maria do Carmo Prucha, Cristina Martins, Valentina F. F. Domingues, Cristina Delerue-Matos, Claudia C. Dias, Luis Filipe R. Azevedo, Conceicao Calhau, Joao Costa Leite, Carla Ramalho, Elisa Keating, Virginia Cruz Fernandes
Summary: The aim of this study was to assess the exposure of pregnant women in Portugal to 3-phenoxybenzoic acid (3-PBA) and its association with maternal outcomes and newborn anthropometric measures. The study found that pregnant women in Portugal are exposed to 3-PBA, particularly during summer, and this exposure may be associated with maternal clinical features.
Article
Electrochemistry
Alvaro Torrinha, Miguel Tavares, Cristina Delerue-Matos, Simone Morais
Summary: This study developed a biological electrode for the fabrication of a biobattery and as a biosensor. The biobattery produced an open circuit potential of 1.69 V and a maximum power of 40 mu W, capable of powering a digital watch for over 2 hours. The biosensor demonstrated high sensitivity and a low limit of detection.
ELECTROCHIMICA ACTA
(2023)
Article
Engineering, Chemical
Cristina Soares, Manuela M. Moreira, Sandra Ramos, M. J. Ramalhosa, Manuela Correia, Jaroslava Svarc-Gajic, Cristina Delerue-Matos, M. Fatima Barroso
Summary: Different extraction techniques were compared to extract phenolic compounds from fruit processing residues. Microwave-assisted extraction (MAE) showed the highest recovery of polyphenolic compounds. Pomegranate peels extracted by M60C and MAE had the highest phenolic content and antioxidant activity. The study highlights the potential of agricultural by-products as a source of phenolic compounds, providing a feasible solution to enhance nutrition and reduce environmental waste.
Article
Engineering, Chemical
Tanja Brezo-Borjan, Jaroslava Svarc-Gajic, Simone Morais, Cristina Delerue-Matos, Francisca Rodrigues, Ivana Loncarevic, Biljana Pajin
Summary: Orange peels were treated with subcritical water to obtain extracts rich in bioactive compounds. The highest total phenolics content, total flavonoids content, and total antioxidant capacity were obtained at low temperatures and short extraction times. These results demonstrate the potential of subcritical water treatment as a green technology for obtaining bioactive compounds.
Article
Biochemistry & Molecular Biology
Maria Luz Maia, Clara Grosso, M. Fatima Barroso, Aurora Silva, Cristina Delerue-Matos, Valentina Fernandes Domingues
Summary: This study characterized shrimp shell waste from Palaemon serratus and Palaemon varians from the Portuguese coast. The waste showed antioxidant and antimicrobial activities, as well as high levels of carotenoids. These findings are important in recognizing the potential value of shrimp shell waste as colorants and preservatives with antioxidant protection capacity in the food industry.
Review
Biochemistry & Molecular Biology
Anis Ben Hsouna, Carmen Sadaka, Ivana Generalic Mekinic, Stefania Garzoli, Jaroslava Svarc-Gajic, Francisca Rodrigues, Simone Morais, Manuela M. Moreira, Eduarda Ferreira, Giorgia Spigno, Tanja Brezo-Borjan, Boutheina Ben Akacha, Rania Ben Saad, Cristina Delerue-Matos, Wissem Mnif
Summary: Citrus fruits are important in the fruit trade due to their large-scale production of fresh fruits and processed products. They provide essential nutrients such as vitamins, minerals, terpenes, flavonoids, coumarins, and dietary fibers. This review systematically summarizes the phytochemical composition, beneficial effects, and potential applications of citrus fruits and their by-products. The knowledge gathered contributes to future conscious use of citrus fruits in the food industry, food packaging, and cosmetic industry.
Review
Infectious Diseases
Jose Carlos Eloi de Queiroz, Jose Roberto S. A. Leite, Andreanne Gomes Vasconcelos
Summary: Antimicrobial resistance poses a significant threat to global health, food security, and development. This study reviewed literature on the antimicrobial activity of plant species from Brazilian biomes. The findings demonstrated that plants from various Brazilian biomes exhibit antimicrobial properties against fungi and bacterial strains.
Article
Chemistry, Medicinal
Yulla Klinger de Carvalho Leite, Antonia Carla de Jesus Oliveira, Patrick Veras Quelemes, Napoleao Martins Argolo Neto, Camila Ernanda Sousa de Carvalho, Huanna Waleska Soares Rodrigues, Michel Mualem de Moraes Alves, Fernando Aecio de Amorim Carvalho, Daniel Dias Rufino Arcanjo, Edson Cavalcanti da Silva-Filho, Alessandra Durazzo, Massimo Lucarini, Maria Acelina Martins de Carvalho, Durcilene Alves da Silva, Jose Roberto de Souza de Almeida Leite
Summary: In this study, a scaffold based on chitosan and phthalated cashew tree gum was developed and tested as a support for the growth of human mesenchymal stem cells. The scaffold showed high swelling rate and appropriate pore sizes analyzed by scanning electron microscopy. Cells seeded on the scaffold exhibited typical morphology, attachment, and adequate distribution inside the matrix pores.
Review
Chemistry, Medicinal
Rita Oliveira, Isabel F. Almeida
Summary: Topical treatments are important for skin diseases, but adherence is often poor. The choice of topical vehicles for drug delivery influences treatment outcomes and patient satisfaction. Patient-centric drug-product design, taking into account the patient's needs and preferences, can improve adherence to topical treatments.
Article
Chemistry, Medicinal
Maira Bernardes Alves, Andreanne Gomes Vasconcelos, Amandda Evelin Silva de Carvalho, Robson Camilotti Slompo, Bruno Silva Sa, Maria Julia Lima Goncalves, Liz Nayara Ribeiro da Costa Lima Moura, Ana Karolinne da Silva Brito, Jose Vinicius de Sousa Franca, Maria do Carmo de Carvalho e Martins, Marcia dos Santos Rizzo, Susana Soares, Veronica Bastos, Felipe Saldanha de Araujo, Bassam Felipe Mogharbel, Katherine Athayde Teixeira de Carvalho, Helena Oliveira, Alexandra Placido, Daniel Dias Rufino Arcanjo, Eder Alves Barbosa, Jose Roberto de Souza de Almeida Leite
Summary: This study investigates different formulations of lycopene, including lycopene-rich extract from red guava, purified lycopene from red guava, and a self-emulsifying drug delivery system loaded with purified lycopene. The results suggest that these formulations have potential use in the treatment of chronic illnesses. The study shows that lycopene-rich extract can reduce hepatic degenerative changes in hypercholesterolemic hamsters, purified lycopene does not exhibit cytotoxicity, and the self-emulsifying drug delivery system demonstrates good stability.
Article
Ecology
Maria Faria, Tamires Bertocco, Ana Barroso, Manuela Carvalho, Felicia Fonseca, Cristina Delerue Matos, Tomas Figueiredo, Amalia Sequeira Braga, Teresa Valente, Raimundo Jimenez-Ballesta
Summary: Wildfires can disrupt ecosystems, especially at the soil level, making it susceptible to degradation. However, there is no consensus on the analytical method for determining soil pH, particularly in burned soils. This study aimed to evaluate the effect of different analytical protocols on soil pH results.
Review
Biochemistry & Molecular Biology
Catia Ferreira, Manuela M. Moreira, Cristina Delerue-Matos, Mafalda Sarraguca
Summary: As the world population increases, the overexploitation of natural resources has become a global concern. Changing the way we produce and consume is crucial for protecting the planet and our way of living. Agriculture activities contribute significantly to greenhouse gas emissions, and valorizing food waste is important for reducing the environmental impact of these activities. Among various extraction techniques, subcritical water extraction (SWE) is a green method that allows high yields using only water as the solvent. This review provides an overview of the SWE process for extracting bioactive compounds from grape biomass, with a focus on circular economy and green extraction.