Article
Multidisciplinary Sciences
Ming Wang, Yalong Yang, Dilay Cansever, Yiming Wang, Crystal Kantores, Sebastien Messiaen, Delphine Moison, Gabriel Livera, Svetoslav Chakarov, Tobias Weinberger, Christopher Stremmel, Monika Fijak, Britta Klein, Christiane Pleuger, Zhexiong Lian, Wentao Ma, Qingzhi Liu, Kathrin Klee, Kristian Handler, Thomas Ulas, Andreas Schlitzer, Joachim L. Schultze, Burkhard Becher, Melanie Greter, Zhaoyuan Liu, Florent Ginhoux, Slava Epelman, Christian Schulz, Andreas Meinhardt, Sudhanshu Bhushan
Summary: Macrophages in the testis and epididymis originate from different stages of cell development and can self-maintain independently of bone marrow hematopoietic cells in a steady state. However, during radiation-induced macrophage ablation or infection, bone marrow-derived cells are recruited to the testis and epididymis, leading to an inflammatory response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Agriculture, Dairy & Animal Science
Marcelo Martinez-Barbitta, Margherita Maranesi, Francesca Mercati, Daniele Marini, Polina Anipchenko, Luca Grispoldi, Beniamino T. Cenci-Goga, Massimo Zerani, Cecilia Dall'Aglio
Summary: ADIPOQ, secreted by adipocytes, plays a key role in energy homeostasis and is involved in modulating the reproductive system. Our study found that the ADIPOQ/ADIPOQ receptor system may regulate the testicular activity of male rams during the non-breeding season.
Article
Biology
Yasmine Asaad Mansour, El-Sayed M. M. Mosallam, Shaymaa Hussein, Ebtihal M. M. Elleithy, Ihab M. Moussa, Ayman S. Mubarak, Turki M. Dawoud, Roua A. Alsubki, Jwaher H. Alhaji, Hassan A. Hemeg, Gehad A. H. EL-Bargeesy
Summary: The study illustrated the distribution of androgen and vitamin D receptors in the epididymis of sexually mature ram, suggesting that both receptors play a role in regulating the normal function of the ram epididymis.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Developmental Biology
Tianjiao Li, Yinghua Lv, Zhili Wu, Ming Guo, Ruifang Liu, Wenxian Zeng, Yi Zheng
Summary: Chromium and its compounds are widely used in industry and have a close association with people's lives. Excessive exposure to hexavalent chromium can cause oxidative damage to various organs, including the testes, which poses a serious threat to male reproductive fitness. Melatonin, as an endogenous antioxidant, holds promise for the treatment of reproductive disorders. In this study, the protective role of melatonin against Cr(VI)-induced testicular damage and its effects on sperm quality and fertility were assessed in a mouse model.
MOLECULAR HUMAN REPRODUCTION
(2023)
Article
Endocrinology & Metabolism
Hanhao Shi, Nazar Ali Korejo, Asghar Ali Kamboh, Rashid Ali Korejo, Fangxiong Shi
Summary: Diabetes and hyperthyroidism often co-exist, and their interaction can have detrimental effects on male reproductive health, as shown in a study using mice. Both diabetes and hyperthyroidism reduced sperm count, while only diabetes significantly decreased rapid progressive sperm motility. Histomorphometric analysis revealed damaging effects on testicular and epididymal tissues in mice with diabetes and hyperthyroidism.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Urology & Nephrology
Anthony D'Oro, Ilina Rosoklija, Elizabeth B. Yerkes, Bruce W. Lindgren, Karen Rychlik, Earl Y. Cheng
Summary: Patients with proximal hypospadias have an increased risk of acquired cryptorchidism, and operative notes reveal a high rate of epididymal nonfusion with ascended testes. Close monitoring of testis position is necessary for these patients.
JOURNAL OF UROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marta Himelreich-Peric, Ana Katusic-Bojanac, Marko Hohsteter, Nino Sincic, Vedrana Muzic-Radovic, Davor Jezek
Summary: Mast cells (MCs) play a crucial role in regulating and mediating allergic responses and tissue remodeling in the testis and epididymis. Studies have shown that MCs may be responsible for testicular tissue fibrosis in different causes of infertility. However, there is inconsistency in experimental design, animal strain, and detection methods used in the literature. Further research is needed to find the most suitable model and improve experimental design.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Veterinary Sciences
Caterina Squillacioti, Alessandra Pelagalli, Loredana Assisi, Anna Costagliola, Luc Van Nassauw, Nicola Mirabella, Giovanna Liguori
Summary: The expression and localization of OXB and OX2R were found to be different in the reproductive system of normal and cryptorchid dogs. Additionally, the mRNA expression of related genes was higher in cryptorchid dogs.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Mohsen Shayestehyekta, Tayebeh Mohammadi, Leila Soltani, Mehrdad PooyanMehr
Summary: The study examines the protective effects of different melatonin concentrations on fresh ram epididymis spermatozoa. The results suggest that melatonin can increase sperm viability and motility, reduce oxidative stress damage, and prolong sperm preservation time.
REPRODUCTION IN DOMESTIC ANIMALS
(2022)
Article
Cell Biology
Xue Zhang, Yong Zuo, Jianhua Zhang, Di Zhang, Muhammad Naeem, Yanzhong Chang, Zhenhua Shi
Summary: Sevoflurane, a commonly used inhalation anesthetic, has a detrimental effect on spermatogenesis and fertilization in male animals. This study explores the mechanism behind this impact, suggesting that Sev disrupts iron metabolism in the testis and epididymis, leading to inhibited sperm production. The damaging effects of Sev on fertility can be ameliorated through iron supplementation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
Yanping Huang, Xiangping Li, Xiangzhou Sun, Jiahui Yao, Fengxin Gao, Zhenqing Wang, Jiaying Hu, Zhu Wang, Bin Ouyang, Xiangan Tu, Xuenong Zou, Wei Liu, Mujun Lu, Chunhua Deng, Qiyun Yang, Yun Xie
Summary: This study investigates the phenotypes and transcriptomes of different regions of the male mouse reproductive tract to explore the mechanisms underlying reproductive aging. It identifies region-specific genes and highlights the role of immune response-associated factors in male reproductive aging. The findings contribute to our understanding of male reproductive aging and infertility.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Environmental Sciences
Massimo Venditti, Mariem Ben Rhouma, Maria Zelinda Romano, Imed Messaoudi, Russel J. Reiter, Sergio Minucci
Summary: This study found that melatonin can alleviate the damage of cadmium on the adult rat testis, including decreased testosterone concentrations, altered sperm parameters, and disruption of the blood-testis barrier and germ cell structure. Melatonin can reduce oxidative damage caused by cadmium, reverse observed changes, and improve sperm quality.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Veterinary Sciences
Mosleh M. Abumaghaid, Aaser M. Abdelazim, Tareg M. Belali, Muhanad Alhujaily, Islam M. Saadeldin
Summary: This study is the first to investigate the presence of mRNA cargo in the EVs of male rabbit reproductive tract cells, providing a model for stimulating female rabbits after semen deposition.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
William H. Walker, Paul S. Cooke
Summary: Steroid hormones can diffuse through cell membranes and bind with intracellular receptors to regulate physiological processes. Mouse models have been used to study the regulation of testis and reproductive tract processes by androgens, estrogens, and glucocorticoids. These models have provided important insights into the molecular mechanisms of steroid hormone regulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Yan Sun, Yonghui Wang, Yuhua Li, Faheem Akhtar, Changfa Wang, Qin Zhang
Summary: RNA-seq was performed to detect circRNA expression profiles in adult donkey testes. A total of 1971 differentially expressed circRNAs were identified, with 1472 downregulated and 499 upregulated in the testis. Additionally, several critical circRNAs associated with testis development and spermatogenesis were discovered. These findings provide a valuable foundation for identifying and characterizing key circRNAs involved in testis development and spermatogenesis.
Article
Agriculture, Dairy & Animal Science
S. Gimeno-Martos, M. Santorroman-Nuez, J. A. Cebrian-Perez, T. Muino-Blanco, R. Perez-Pe, A. Casao
Summary: The steroid hormones E2 and P4 can induce the acrosome reaction in ram spermatozoa through receptor-mediated mechanisms. Estrogen receptors (ER) and progesterone receptors (PR) are present in these cells, suggesting a receptor-mediated effect of the hormones on sperm function.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2021)
Article
Cell Biology
Sara Miguel-Jimenez, Blanca Pina-Beltran, Silvia Gimeno-Martos, Melissa Carvajal-Serna, Adriana Casao, Rosaura Perez-Pe
Summary: This study found NOX5 in ram spermatozoa and demonstrated that melatonin can prevent changes related to sperm capacitation by modulating NOX5 activity. This suggests that melatonin plays a role in antioxidant defense in ram sperm by influencing NOX5 during capacitation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Melissa Carvajal-Serna, Sara Miguel-Jimenez, Rosaura Perez-Pe, Adriana Casao
Summary: Testicular ultrasound can be a valuable tool for predicting ram seminal quality, with white and grey pixels correlating with poor sperm parameters and tubular density and lumen area correlating with good sperm quality. Ultrasound-video analysis allows for both macroscopic and microscopic evaluation of testicular echotexture, providing a non-invasive method for assessing ram fertility.
Article
Cell Biology
Marta Montori-Grau, David Aguilar-Recarte, Mohammad Zarei, Javier Pizarro-Delgado, Xavier Palomer, Manuel Vazquez-Carrera
Summary: This study found that endoplasmic reticulum (ER) stress downregulates the expression of PGC-1 alpha in skeletal muscle through the activation of ATF4 and the mTOR-CRTC2 pathway. These findings suggest that inhibition of ATF4 and the mTOR-CRTC2 axis could be a therapeutic target for insulin resistant states.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Cell Biology
Felipe Eduardo Luedke, Caroline Pereira da Costa, Camilla Mota Mendes, Thais Rose dos Santos Hamilton, Marcella Pecora Milazzotto, Mayra E. O. A. Assumpcao, Marcelo Demarchi Goissis
Summary: This study found that supplementation of fetal bovine serum (FBS) in embryonic culture medium can affect cell differentiation during early bovine embryo development. Absence of FBS reduces blastocyst rates, but there is no reduction when 33% volume renewal of the medium is done at 90 hours post insemination. Additionally, FBS supplementation alters the allocation of trophectoderm (TE) and primitive endoderm cells.
Article
Developmental Biology
Sara Miguel-Jimenez, Melissa Carvajal-Serna, Victoria Pena-Delgado, Adriana Casao, Rosaura Perez-Pe
Summary: This study investigates the effect of melatonin and nitric oxide on capacitation and apoptotic-like changes in EGF-capacitated ram spermatozoa. The results indicate that NO levels and apoptotic-related markers increase after EGF incubation. Melatonin has a bimodal role in sperm EGF-capacitation, but neither of the two concentrations prevents the increase in apoptotic-like markers or NO levels. However, melatonin at 1μM prevents the activation of JNK.
REPRODUCTION FERTILITY AND DEVELOPMENT
(2022)
Article
Reproductive Biology
Sara Miguel-Jimenez, Sonia Borao, Virginia Portoles-Bayod, Adriana Casao, Rosaura Perez-Pe
Summary: The study investigated the effects of season and sperm capacitation state on the chemotactic response of ram spermatozoa to melatonin. The results showed that melatonin can enhance sperm recovery rate and capacitation, indicating a potential chemotactic effect of melatonin on ram spermatozoa.
Article
Agriculture, Dairy & Animal Science
Victoria Pena-Delgado, Melissa Carvajal-Serna, Manuel Fondevila, Maria A. Martin-Cabrejas, Yolanda Aguilera, Gerardo Alvarez-Rivera, Jose A. Abecia, Adriana Casao, Rosaura Perez-Pe
Summary: The aim of this study was to evaluate the effect of a phytomelatonin-rich diet on ram sperm quality and seminal plasma composition. The results showed that the diet, including grape pulp, pomegranate and tomato pomaces, increased melatonin levels in seminal plasma, improved sperm viability and morphology, and protected sperm cells against oxidative damage.
Article
Cell Biology
A. R. Moura, A. R. Santos, J. D. A. Losano, A. F. P. Siqueira, T. R. S. Hamilton, R. Zanella, K. C. Caires, R. Simoes
Summary: Our study found that Wagyu bulls have lower sperm motility compared to Nellore and Angus bulls, but did not differ in terms of plasma and acrosome membranes integrity, mitochondrial potential, chromatin resistance, sperm lipid peroxidation, or hormone (LH and testosterone) concentrations.
Editorial Material
Biology
Pilar Santolaria, Jessica P. Rickard, Rosaura Perez-Pe
Review
Agriculture, Dairy & Animal Science
Carlos Alonso Paco Nagaki, Thais Rose dos Santos Hamilton, Mayra Elena Ortiz D Avila Assumpcao
Summary: The evaluation of sperm chromatin plays a crucial role in predicting bull reproductive capacity, although the physiological mechanisms of protamination are still poorly understood.
ANIMAL REPRODUCTION
(2022)
